Efficacy of mindfulness-based cognitive therapy in relation to prior history of depression: randomised controlled trial
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Background: There appears to be consensus that patients with only one or two prior depressive episodes do not benefit from treatment with mindfulness-based cognitive therapy (MBCT). Aims: To investigate whether the effect of MBCT on residual depressive symptoms is contingent on the number of previous depressive episodes (trial number NTR1084). Method: Currently non-depressed adults with residual depressive symptoms and a history of depression ($2 prior episodes: n = 71; $3 episodes: n = 59) were randomised to MBCT (n = 64) or a waiting list (control: n = 66) in an open-label, randomised controlled trial. The main outcome measured was the reduction in residual depressive symptoms (Hamilton Rating Scale for Depression, HRSD-17). Results: Mindfulness-based cognitive therapy was superior to the control condition across subgroups (β =–0.56, P<0.001). The interaction between treatment and subgroup was not significant (β = 0.45, P = 0.16). Conclusions: Mindfulness-based cognitive therapy reduces residual depressive symptoms irrespective of the number of previous episodes of major depression.
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The original work with MBCT has been extended to suggest promising evidence for use in treatment-resistant depression, in people with current symptoms of anxiety or depression, including those currently depressed and suicidal, and in improving residual symptoms regardless of the number of previous episodes of depression.
“The original work with MBCT has been extended to suggest promising evidence for use in treatment-resistant depression,11,12 in people with current symptoms of anxiety or depression,13 including those currently depressed and suicidal,14 and in improving residual symptoms regardless of the number of previous episodes of depression.15”
From Mindfulness in psychiatry - Where are we now? (2016) · cites this paper as [12]
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Clinical Perspectives: Mindfulness-Based Cognitive Therapy and Mood Disorders
Willett, B. R., & Lau, M. A. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2263-5_13
Cognitive Reactivity in Depression: Examining a Hypothesis of Depressive Relapse
Ching, L. E. (2013) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/25346
Psychological therapies for depression with regard to their utility–a review
Balla, D. (2013) · IOSR Journal of Humanities and Social Science · doi:10.9790/0837-1342026
Mindfulness-Based Cognitive Therapy: Theoretical Background and Use
Chybicki, M. (2016) · Nursing and Public Health · doi:10.17219/pzp/61710
Meditation for Major Depressive Disorder: A Systematic Review
Sorbero, M. E. S., Ahluwalia, S. C., Reynolds, K. A., Lovejoy, S. L., Farris, C. A., Sloan, J., Miles, J. N. V., Vaughan, C., Kandrack, R., Apaydin, E. A., et al. (2015) · RAND Corporation eBooks · doi:10.7249/rr1138
Tratamiento no farmacológico de la depresión
Esteban, S. (2013) · Evidencia actualizacion en la práctica ambulatoria · doi:10.51987/evidencia.v16i2.6167
van Vreeswijk, M., Broersen, J., & Schurink, G. (2014) · Wiley eBooks · doi:10.1002/9781118753125.biblio
Grundlagen der Diagnostik und Therapie
(2024) · Elsevier eBooks · doi:10.1016/b978-3-437-22487-4.16001-0
Sunzeri, E., & Sunzeri, F. (2026) · Springer eBooks · doi:10.1007/978-3-032-14465-2_17
Durães, R. S. S., Vargas, Z. P., Dias, A. C. G., Neto, F. L., Ramos, R. T., & Serafim, A. D. P. (2026) · Journal of Marital and Family Therapy · doi:10.1111/jmft.70169
- Authors
- Geschwind, N., Peeters, F., Huibers, M., van Os, J., & Wichers, M.
- Affiliations
- Maastricht University Medical Centre (NL)
- Maastricht University (NL)
- Corresponding author
- Geschwind, Nicole
- Venue
- British Journal of Psychiatry
- Publisher
- Royal College of Psychiatrists
- Published
- 2012-10
- Volume
- 201
- Issue
- 4
- Pages
- 320-325
- ISSN
- 0007-1250 (ISSN-L)
- 1472-1465
- OpenAlex
- W2150182698
- Cited by
- 89
- References
- 30
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 6 · 2017: 8 · 2016: 10 · 2015: 10 · 2014: 13 · 2013: 12 · 2012: 2
- FWCI
- 13.40
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The British Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- VU Research Portal (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (916.76.147)
- Servier
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- mindfulness-based cognitive therapy, residual depressive symptoms, history of depression, number of depressive episodes, major depressive disorder, subgroup analysis, treatment effect heterogeneity
- MeSH terms
- Adult, Depression, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Cognitive Behavioral Therapy, Meditation
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