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Cited by 155

The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.

Formation and function of apolipoprotein E-containing lipoproteins in the nervous system

Vance, Jean E., Hayashi, Hideki·2010·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
DOI 10.1016/j.bbalip.2010.02.007
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Abstract

The strongest known genetic risk factor for the development of late-onset Alzheimer disease is inheritance of the apolipoprotein (apo) E4 (epsilon4 allele) although the mechanisms underlying this connection are still not entirely clear. In this review, we shall discuss the role of apo E in the brain, particularly in relation to Alzheimer disease. Cholesterol transport and homeostasis in the central nervous system (CNS) are separated from that in the peripheral circulation by the blood-brain barrier. However, the brain operates its own lipoprotein transport system that is mediated by high density lipoprotein-sized, apo E-containing lipoproteins that are synthesized and secreted by glial cells (primarily astrocytes). Several ATP-binding cassette (ABC) transporters are expressed in the brain, including ABCA1 and ABCG1 which play important roles in the transfer of phospholipids and cholesterol to apo E. The astrocyte-derived apo E-containing lipoproteins can bind to, and be internalized by, receptors of the low density lipoprotein receptor superfamily that are located on the surface of neurons. In addition to these receptors serving as endocytosis receptors for lipoproteins, several of these receptors also act as signaling receptors in neurons and activate pathways involved in axonal growth, as well as neuronal survival. These beneficial pathways appear to be enhanced to a greater extent by apo E3 than by apo E4. Apo E has also been implicated in the deposition of amyloid plaques…

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Crossref · 10.1016/j.bbalip.2010.02.007

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55 of 55 references verified0 citation errors · 0 not checkable

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  • Activating ABCA1 facilitates the transport of intracellular cholesterol from endosomes into nascent ApoE to form ApoE HDL.

    “Activating ABCA1 facilitates the transport of intracellular cholesterol from endosomes into nascent ApoE to form ApoE HDL (Vance and Hayashi, 2010).”

    From ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes (2019) · cites this paper as Vance and Hayashi, 2010

  • Astrocytes make cholesterol and transport it to neurons with apolipoprotein E (apoE).

    “Instead, astrocytes make cholesterol and transport it to neurons with apolipoprotein E (apoE) (25–27).”

    From Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol (2021) · cites this paper as [27]

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Metadata

Authors
Vance, J. E., & Hayashi, H.
Venue
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher
Elsevier BV
Published
2010-08
Volume
1801
Issue
8
Pages
806-818
ISSN
1388-1981
DOI
10.1016/j.bbalip.2010.02.007
Cited by
155
References
55
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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