Cited by 130Posttraumatic Stress Disorder ResearchStress Responses and CortisolIntensive Care Unit Cognitive Disorders

Can Posttraumatic Stress Disorder Be Prevented with Glucocorticoids?

SCHELLING, GUSTAV, ROOZENDAAL, BENNO, de QUERVAIN, DOMINIQUE J.‐F.·2004·Annals of the New York Academy of Sciences

Abstract

A bstract: Patients with critical illness who are treated in an intensive care unit (ICU) often report traumatic memories from ICU treatment, receive exogenously administered glucocorticoids for medical reasons, and have a relatively high incidence of chronic stress symptoms and posttraumatic stress disorder (PTSD) during follow‐up. ICU therapy could therefore represent a useful model for investigating glucocorticoid effects on traumatic memories and PTSD development. Studies in long‐term survivors of ICU treatment demonstrated a clear and vivid recall of different categories of traumatic memory such as nightmares, anxiety, respiratory distress, or pain. The incidence and intensity of PTSD symptoms increased with the number of categories of traumatic memory present. The prolonged administration of glucocorticoids (stress doses of hydrocortisone) to critically ill patients resulted in a significant reduction of PTSD symptoms measured after recovery without influencing the number of categories of traumatic memory. This protective effect of cortisol can possibly be explained by a cortisol‐induced temporary impairment in traumatic memory retrieval which has previously been demonstrated in both rats and humans. Therefore, stress doses of hydrocortisone could be useful for prophylaxis and treatment of PTSD.

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Crossref · 10.1196/annals.1314.013

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  • Data on human PTSD support a protective role for adequate glucocorticoid levels at the time of trauma.

    “Data on human PTSD support a protective role for adequate glucocorticoid levels at time of trauma.”

    From Neurobiological and Systemic Effects of Chronic Stress (2017) · cites this paper as [35]

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Authors
SCHELLING, G., ROOZENDAAL, B., & de QUERVAIN, D. J. ‐.
Affiliations
Ludwig-Maximilians-Universität München (DE)
Corresponding author
SCHELLING, GUSTAV
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2004-12
Volume
1032
Issue
1
Pages
158-166
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
OpenAlex
W2131975102
Cited by
130
References
43
Citations by year
2025: 2 · 2024: 1 · 2023: 2 · 2022: 7 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 6 · 2016: 9 · 2015: 11 · 2014: 5 · 2013: 5 · 2012: 7
FWCI
12.97
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
Keywords
post-traumatic stress disorder, glucocorticoids, cortisol, intensive care unit, critical illness, traumatic memory, PTSD prevention, memory retrieval
MeSH terms
Critical Care, Emotions, Glucocorticoids, Humans, Hydrocortisone, Memory, Stress Disorders, Post-Traumatic, Critical Illness, Survivors

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