The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Exercise and Hormesis: Activation of Cellular Antioxidant Signaling Pathway
Abstract
Abstract: Contraction‐induced production of reactive oxygen species (ROS) has been shown to cause oxidative stress to skeletal muscle. As an adaptive response, muscle antioxidant defense systems are upregulated after heavy exercise. Nuclear factor (NF) κB and mitogen‐activated protein kinases (MAPKs) are the major oxidative stress–sensitive signal transduction pathways in mammalian tissues. Activation of NF‐κB signaling cascade has been shown to enhance the gene expression of important enzymes, such as mitochondrial superoxide dismutase (MnSOD) and inducible nitric oxide synthase (iNOS). MAPK activations are involved in a variety of cellular functions including growth, proliferation, and adaptation. We investigated the effect of an acute bout of exercise on NF‐κB and MAPK signaling, as well as on the time course of activation, in rat skeletal muscle. In addition, we studied the role of ROS in the exercise‐induced upregulation of MnSOD and iNOS, and the potential interactions of NF‐κB and MAPK in the signaling of these enzymes. Our data suggest that ROS may serve as messenger molecules to activate adaptive responses through these redox‐sensitive signaling pathways to maintain cellular oxidant‐antioxidant homeostasis during exercise.
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Cites
Function and Activation of NF-kappaB in the Immune System
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Moderate exercise is an antioxidant: Upregulation of antioxidant genes by training
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Self-citationExercise is the real polypill.
Fiuza-Luces, C., Garatachea, N., Berger, N. A., & Lucia, A. (2013) · Physiology · doi:10.1152/physiol.00019.2013 · Cited by 791
Exercise, oxidative stress and hormesis
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Mitohormesis: Promoting Health and Lifespan by Increased Levels of Reactive Oxygen Species (ROS)
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Reactive Oxygen Species Are Signalling Molecules for Skeletal Muscle Adaptation
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Exercise, MAPK, and NF-κB signaling in skeletal muscle
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Exercise, Vascular Wall and Cardiovascular Diseases: An Update (Part 1)
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Viewpoint: Mechanisms of Action and Therapeutic Potential of Neurohormetic Phytochemicals
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Turner, J. E. (2016) · Biogerontology · doi:10.1007/s10522-016-9642-z · Cited by 112
Exercise induces interleukin‐8 receptor (CXCR2) expression in human skeletal muscle
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Metadata
- Authors
- JI, L. L., GOMEZ‐CABRERA, M., & VINA, J.
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2006-05
- Volume
- 1067
- Issue
- 1
- Pages
- 425-435
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1982167919
- Cited by
- 450
- References
- 2
- FWCI
- 30.96
- Type
- journal article
- Language
- en
- Open access
- closed
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