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Cited by 286

The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.

Insulin-Lowering Agents in the Management of Polycystic Ovary Syndrome

Open access
De Leo, Vincenzo, la Marca, Antonio, Petraglia, Felice·2003·Endocrine Reviews
DOI 10.1210/er.2002-0015
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Abstract

Polycystic ovary syndrome (PCOS) is a medical condition that has brought multiple specialists together.Gynecologists, endocrinologists, cardiologists, pediatricians, and dermatologists are all concerned with PCOS patients and share research data and design clinical trials to learn more about the syndrome.Insulin resistance is a common feature of PCOS and is more marked in obese women, suggesting that PCOS and obesity have a synergistic effect on the magnitude of the insulin disorder.Hyperinsulinemia associated with insulin resistance has been causally linked to all features of the syndrome, such as hyperandrogenism, reproductive disorders, acne, hirsutism, and meta-bolic disturbances.Women with PCOS should be evaluated for cardiovascular risk factors, such as lipid profile and blood pressure.Modification of diet and lifestyle should be suggested to those who are obese.Several insulin-lowering agents have been tested in the management of PCOS.In particular, metformin is the only drug currently in widespread clinical use for treatment of PCOS.In a high percentage of patients, treatment with metformin is followed by regularization of menstrual cycle, reduction in hyperandrogenism and in cardiovascular risk factors, and improvement in response to therapies for induction of ovulation.(Endocrine Reviews 24: 633-667, 2003) I. Introduction II.Definition of PCOS A. Endocrine profile B. Reproductive abnormalities C. Long-term health consequences D. Summary III.Insulin Resistance in PCOS A. Definition and prevalence B. Diagnosis C. Pathogenesis of insulin resistance D. Summary IV.Insulin-Lowering Strategies A. Metformin B. Thiazolidinediones C. Other drugs D. Weight loss E. Summary and clinical recommendations V.

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Metadata

Authors
De Leo, V., la Marca, A., & Petraglia, F.
Venue
Endocrine Reviews
Publisher
The Endocrine Society
Published
2003-10-01
Volume
24
Issue
5
Pages
633-667
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
DOI
10.1210/er.2002-0015
OpenAlex
W2119823280
Cited by
286
References
50
FWCI
17.13
Type
journal article
Language
en
Open access
bronze

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