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Child Health, Developmental Plasticity, and Epigenetic Programming

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Hochberg, Z., Feil, R., Constancia, M., Fraga, M., Junien, C., Carel, J.-C., Boileau, P., Le Bouc, Y., Deal, C. L., Lillycrop, K., Scharfmann, R., Sheppard, A., Skinner, M., Szyf, M., Waterland, R. A., Waxman, D. J., Whitelaw, E., Ong, K., Albertsson-Wikland, K.·2011·Endocrine Reviews
DOI 10.1210/er.2009-0039
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Abstract

Plasticity in developmental programming has evolved in order to provide the best chances of survival and reproductive success to the organism under changing environments. Environmental conditions that are experienced in early life can profoundly influence human biology and long-term health. Developmental origins of health and disease and life-history transitions are purported to use placental, nutritional, and endocrine cues for setting long-term biological, mental, and behavioral strategies in response to local ecological and/or social conditions. The window of developmental plasticity extends from preconception to early childhood and involves epigenetic responses to environmental changes, which exert their effects during life-history phase transitions. These epigenetic responses influence development, cell- and tissue-specific gene expression, and sexual dimorphism, and, in exceptional cases, could be transmitted transgenerationally. Translational epigenetic research in child health is a reiterative process that ranges from research in the basic sciences, preclinical research, and pediatric clinical research. Identifying the epigenetic consequences of fetal programming creates potential applications in clinical practice: the development of epigenetic biomarkers for early diagnosis of disease, the ability to identify susceptible individuals at risk for adult diseases, and the development of novel preventive and curative measures that are based on diet and/or novel epigenetic drugs.

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Metadata

Authors
Hochberg, Z., Feil, R., Constancia, M., Fraga, M., Junien, C., Carel, J.-C., Boileau, P., Le Bouc, Y., Deal, C. L., Lillycrop, K., Scharfmann, R., Sheppard, A., Skinner, M., Szyf, M., Waterland, R. A., Waxman, D. J., Whitelaw, E., Ong, K., & Albertsson-Wikland, K.
Venue
Endocrine Reviews
Publisher
The Endocrine Society
Published
2010-10-22
Volume
32
Issue
2
Pages
159-224
ISSN
  • 0163-769X (ISSN-L)
  • 1945-7189
DOI
10.1210/er.2009-0039
OpenAlex
W2076472141
Cited by
627
References
82
FWCI
37.61
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Child Health, Developmental Plasticity, and Epigenetic Programming. https://app.cochat.ai/papers/10.1210/er.2009-0039
The paper
Hochberg, Z., Feil, R., Constancia, M., Fraga, M., Junien, C., Carel, J.-C., Boileau, P., Le Bouc, Y., Deal, C. L., Lillycrop, K., Scharfmann, R., Sheppard, A., Skinner, M., Szyf, M., Waterland, R. A., Waxman, D. J., Whitelaw, E., Ong, K., & Albertsson-Wikland, K. (2011). Child Health, Developmental Plasticity, and Epigenetic Programming. Endocrine Reviews. https://doi.org/10.1210/er.2009-0039

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.