CoChat
Sign Up
Cited by 671Hormonal and reproductive studiesSperm and Testicular FunctionAdrenal Hormones and Disorders

The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.

Endogenous Testosterone and Mortality in Men: A Systematic Review and Meta-Analysis

Open access
Araujo, Andre B., Dixon, Julia M., Suarez, Elizabeth A., Murad, M. Hassan, Guey, Lin T., Wittert, Gary A.·2011·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2011-1137PMC PMC3200249
Open this paper in CoChat — free accountOpen PDF

Abstract

CONTEXT: Low testosterone levels have been associated with outcomes that reduce survival in men. OBJECTIVE: Our objective was to perform a systematic review and meta-analysis of published studies to evaluate the association between endogenous testosterone and mortality. DATA SOURCES: Data sources included MEDLINE (1966 to December 2010), EMBASE (1988 to December 2010), and reference lists. STUDY SELECTION: Eligible studies were published English-language observational studies of men that reported the association between endogenous testosterone and all-cause or cardiovascular disease (CVD) mortality. A two-stage process was used for study selection. 1) Working independently and in duplicate, reviewers screened a subset (10%) of abstracts. Results indicated 96% agreement, and thereafter, abstract screening was conducted in singlicate. 2) All full-text publications were reviewed independently and in duplicate for eligibility. DATA EXTRACTION: Reviewers working independently and in duplicate determined methodological quality of studies and extracted descriptive, quality, and outcome data. DATA SYNTHESIS: Of 820 studies identified, 21 were included in the systematic review, and 12 were eligible for meta-analysis [n = 11 studies of all-cause mortality (16,184 subjects); n = 7 studies of CVD mortality (11,831 subjects)]. Subject mean age and testosterone level were 61 yr and 487 ng/dl, respectively, and mean follow-up time was 9.7 yr. Between-study heterogeneity was observed among studies of all-cause (P < .001) and CVD mortality (P = 0.06), limiting the ability to provide valid summary estimates. Heterogeneity in all-cause mortality (higher relative risks) was observed in studies that included older subjects (P = 0.020), reported lower testosterone levels (P = 0.018), followed subjects for a shorter time period (P = 0.010), and sampled blood throughout the day (P = 0.030). CONCLUSION: Low endogenous testosterone levels are associated with increased risk of all-cause and CVD death in community-based studies of men, but considerable between-study heterogeneity, which was related to study and subject characteristics, suggests that effects are driven by differences between cohorts (e.g. in underlying health status).

Overview

Integrity signals

Registry

Crossref · 10.1210/jc.2011-1137

Cites

65 of 65 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Cited by

Sorted by citations

See all 671

Related

See all

Metadata

Authors
Araujo, A. B., Dixon, J. M., Suarez, E. A., Murad, M. H., Guey, L. T., & Wittert, G. A.
Affiliations
  • New England Research Institutes (US)
  • Mayo Clinic (US)
  • The University of Adelaide (AU)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2011-10
Volume
96
Issue
10
Pages
3007-3019
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2011-1137
PMC
PMC3200249
OpenAlex
W1987977957
Cited by
671
References
65
Citations by year
2026: 16 · 2025: 31 · 2024: 31 · 2023: 44 · 2022: 52 · 2021: 42 · 2020: 43 · 2019: 40 · 2018: 43 · 2017: 57 · 2016: 47 · 2015: 55 · 2014: 64 · 2013: 61 · 2012: 43
FWCI
7.54
Type
journal article
Language
en
Open access
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Funders
  • Eli Lilly and Company
  • New England Research Institutes
  • National Institutes of Health
  • Medical Research Council
  • Australian Research Council
  • National Health and Medical Research Council
  • National Institute on Aging (R01AG020727)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
endogenous testosterone, androgen deficiency, all-cause mortality, cardiovascular mortality, men, study heterogeneity, community-based cohort
MeSH terms
Adult, Age Factors, Aged, Cardiovascular Diseases, Cause of Death, Humans, Male, Middle Aged, Mortality, Smoking, Survival, Testosterone, United States, Meta-Analysis as Topic, Body Mass Index, Risk Assessment

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review