The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Gut Microbiota Interacts With Brain Microstructure and Function
Abstract
CONTEXT: Evidence from animals suggests that gut microbiota affects brain structure and function but evidence in humans is scarce. OBJECTIVE: This study sought to evaluate potential interactions among gut microbiota composition, brain microstructure, and cognitive tests in obese and nonobese subjects. DESIGN, SETTING, AND PARTICIPANTS: This was a cross-sectional study at a tertiary hospital including 20 consecutive obese and 19 nonobese subjects similar in age and sex. MAIN OUTCOME MEASURES: Gut microbiota (16S bacterial gene pyrosequencing), brain microstructure (diffusion tensor imaging of brain white and gray matter and R2* sequences in magnetic resonance imaging) and cognitive tests. RESULTS: Hierarchical clustering revealed a specific gut microbiota-brain map profile for obese individuals who could be discriminated from nonobese subjects (accuracy of 0.81). Strikingly, Shannon index was linked to R2* and fractional anisotropy of the hypothalamus, caudate nucleus, and hippocampus, suggesting sparing of these brain structures with increased bacterial biodiversity. Microbiota profile also clustered with cognitive function. The relative abundance of Actinobacteria phylum was linked not only to magnetic resonance imaging diffusion tensor imaging variables in the thalamus, hypothalamus, and amygdala but also to cognitive test scores related to speed, attention, and cognitive flexibility. CONCLUSIONS: In sum, obesity status affects microbiota-brain microstructure and function crosstalk.
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“The gut microbiota composition, specifically the abundance of the Actinobacteria phylum, of obese and non-obese subjects was linked with the cognitive testing scores, as well as alterations in neural activity in the thalamus, hypothalamus, and amygdala”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Fernandez-Real et al., 2015
In the citing paper
“suggesting that obesity affects the microbiota composition and subsequent cognitive performance”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Fernandez-Real et al., 2015
In the citing paper
“coupled with alterations in neural activity in the thalamus, hypothalamus, and amygdala, suggesting that obesity affects the microbiota composition and subsequent cognitive performance (Fernandez-Real et al., 2015).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Fernandez-Real et al., 2015
In the citing paper
“One of these studies showed that the gut microbiota composition of obese and non-obese subjects was linked with scores in speed, attention, and cognitive flexibility in a Trail Making Test coupled with alterations in neural activity in the thalamus, hypothalamus, and amygdala, suggesting that obesity affects the microbiota composition and subsequent cognitive performance (Fernandez-Real et al., 20”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Fernandez-Real et al., 2015
In the citing paper
“In a study of non-obese and obese individuals, GM composition was found to be associated with scores of cognitive speed, attention, and flexibility, along with significant changes in neural activity in specific brain regions (thalamus, hypothalamus, and amygdala) (481).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [481]
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Spinal cord injury and gut microbiota: A review
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The Link between Gut Dysbiosis Caused by a High-Fat Diet and Hearing Loss
Kociszewska, D., Chan, J., Thorne, P. R., & Vlajkovic, S. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413177 · Cited by 51
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“, 2020) as well as with gut microbiome in adults (Fernandez-Real et al., 2015; Tillisch et al., 2017).”
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“Increasingly, recent evidence has demonstrated that gut microbiota could indeed affect brain function (9,10).”
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“The gut microbiota (GM) influences both brain structure and cognition (Carabotti et al., 2015; Fernandez-Real et al., 2015; Chen et al., 2021; Feng et al., 2022).”
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Unlocking the mind-gut connection: Impact of human microbiome on cognition
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Out of our skull, in our skin: the Microbiota-Gut-Brain axis and the Extended Cognition Thesis
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The Gut Brain-Axis in Neurological Diseases
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The Brain–Gut Health Initiative (BIGHI): A Prospective Cohort on Psychiatric Disorders in China
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Metadata
- Authors
- Fernandez-Real, J.-M., Serino, M., Blasco, G., Puig, J., Daunis-i-Estadella, J., Ricart, W., Burcelin, R., Fernández-Aranda, F., & Portero-Otin, M.
- Affiliations
- Department of Diabetes, Endocrinology and Nutrition (J.-M.F.-R., W.R.), Institut d'Investigació Biomédica de Girona, CIBER de la Fisiopatología de la Obesidad y la Nutrición (CIBERobn, CB06/03/0010) and Instituto de Salud Carlos III, Girona, 17007 Spain
- Institut National de la Santé et de la Recherche Médicale (M.S., R.B.), Toulouse, France
- Institut d'Investigació Biomèdica de Girona (ES)
- Department of Computer Science, Applied Mathematics, and Statistics (J.D.-E.), University of Girona, Girona, 17071 Spain
- Instituto de Salud Carlos III (ES)
- Department of Psychiatry (F.F.-A.), University Hospital of Bellvitge-IDIBELL, Barcelona, CIBERobn, Instituto Salud Carlos III, Barcelona, 08908 Spain
- Nutren Group, Department of Experimental Medicine (M.P.-O.), PCiTAL-IRBLleida-Universitat de Lleida, Lleida, 25198 Spain
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2015-12-01
- Volume
- 100
- Issue
- 12
- Pages
- 4505-4513
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2188252631
- Cited by
- 167
- References
- 32
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 19 · 2023: 21 · 2022: 19 · 2021: 18 · 2020: 21 · 2019: 18 · 2018: 12 · 2017: 12 · 2016: 7
- FWCI
- 4.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- gut microbiota, obesity, brain microstructure, cognitive function, microbiota-brain axis, white matter integrity, gray matter, hypothalamus, hippocampus, caudate nucleus, actinobacteria, R2* relaxation, fractional anisotropy, bacterial diversity, cognitive flexibility, attention
- MeSH terms
- Adult, Aged, Attention, Body Composition, Brain, Cognition, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Obesity, Reaction Time, Actinobacteria, Biodiversity, Diffusion Tensor Imaging, Microbiota
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