Is the Impact of Starvation on the Gut Microbiota Specific or Unspecific to Anorexia Nervosa? A Narrative Review Based on a Systematic Literature Search
Open accessAbstract
BACKGROUND: The role of the gut microbiota in Anorexia Nervosa (AN) has long been neglected by researchers, although the fact that the former is known to play an important role in health, disease and weight regulation. Cycles of overweight and underweight due to natural states of starvation and refeeding are normal in many vertebrates in their ecological niches. OBJECTIVE: The aim of this review was to compare the similarities and differences of the gut microbiota in eating disorders with conditions of fasting and refeeding in other vertebrates. METHOD: A systematic literature search was conducted in Pubmed and Web of Science to find all relevant studies examining the gut microbiota in eating disorders and different states of fasting in vertebrates for this narrative review. RESULTS: Gut microbiota appears to differ in AN versus normal-weight individuals. Induced fasting conditions in other vertebrates resulted in heterogeneous effects on gut microbiota with respect to their richness, diversity and community structures. The findings for hibernating animals were generally consistent. A decrease in microbial richness and diversity was observed in the hibernating animal compared to the active animal, and the community structures were linked to these conditions. Some similarities and differences between AN and different states of fasting in other vertebrates were found. CONCLUSION: The complexity of the relationship between fasting and gut microbiota is difficult to interprete. A deeper biological understanding is necessary to identify promising approaches for the modulation of the AN gut microbiota to support established psychotherapies.
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Studies of the gut microbiota in anorexia nervosa patients are mostly characterized by heterogeneity in methodology and small sample sizes.
“Various studies have explored the gut microbiota of anorexia nervosa patients with the majority of them being characterized by heterogeneity in the methodology and small sample sizes (for review see: [167]).”
From The athletic gut microbiota (2020) · cites this paper as [167]
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Million, M., Angelakis, E., Maraninchi, M., Henry, M., Giorgi, R., Valero, R., Vialettes, B., & Raoult, D. (2013) · International Journal of Obesity · doi:10.1038/ijo.2013.20 · Cited by 362 · see citing works
RetractedPfleiderer, A., Lagier, J., Armougom, F., Robert, C., Vialettes, B., & Raoult, D. (2013) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-013-1900-2 · Cited by 154 · see citing works
RetractedPreferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823 · see citing works
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164 · see citing works
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement
Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2009.06.005 · Cited by 19,575 · see citing works
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gotzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · BMJ · doi:10.1136/bmj.b2700 · Cited by 17,648 · see citing works
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works
Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548 · see citing works
Linking long-term dietary patterns with gut microbial enterotypes
Wu, G. D., Chen, J., Hoffmann, C., Bittinger, K., Chen, Y.-Y., Keilbaugh, S. A., Bewtra, M., Knights, D., Walters, W. A., Knight, R., et al. (2011) · Science · doi:10.1126/science.1208344 · Cited by 6,513 · see citing works
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works
Turnbaugh, P. J., Ley, R. E., Hamady, M., Fraser-Liggett, C. M., Knight, R., & Gordon, J. I. (2007) · Nature · doi:10.1038/nature06244 · Cited by 6,091 · see citing works
(2023) · doi:10.1126/science · Cited by 6,063 · see citing works
Diversity, stability and resilience of the human gut microbiota
Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K., & Knight, R. (2012) · Nature · doi:10.1038/nature11550 · Cited by 5,533 · see citing works
Functional interactions between the gut microbiota and host metabolism
Tremaroli, V., & Bäckhed, F. (2012) · Nature · doi:10.1038/nature11552 · Cited by 4,387 · see citing works
Colman (2022) · doi:10.1073/pnas · Cited by 4,370 · see citing works
The gut microbiota--masters of host development and physiology
Sommer, F., & Bäckhed, F. (2013) · Nature Reviews Microbiology · doi:10.1038/nrmicro2974 · Cited by 3,681 · see citing works
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · Italian Journal of Public Health · doi:10.2427/5768 · Cited by 3,374 · see citing works
Turnbaugh, P. J., Bäckhed, F., Fulton, L., & Gordon, J. I. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.02.015 · Cited by 2,915 · see citing works
Energy contributions of volatile fatty acids from the gastrointestinal tract in various species
Bergman, E. N. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.2.567 · Cited by 2,750 · see citing works
Gut–brain axis: How the microbiome influences anxiety and depression
Foster, J. A., & McVey Neufeld, K.-A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.01.005 · Cited by 2,460 · cited 1× · see citing works
“Furthermore, there is an evidence that the microbiota influences brain function and the behaviour of the host by communicating with the brain via the gut-brain axis [41, 42].”
BackgroundMICROBIAL ECOLOGY OF THE GASTROINTESTINAL TRACT
Savage, D. C. (1977) · Annual Review of Microbiology · doi:10.1146/annurev.mi.31.100177.000543 · Cited by 2,436 · see citing works
The PICO strategy for the research question construction and evidence search
Santos, C. M. D. C., Pimenta, C. A. D. M., & Nobre, M. R. C. (2007) · Revista Latino-Americana de Enfermagem · doi:10.1590/s0104-11692007000300023 · Cited by 2,342 · see citing works
Psychosomatic medicine in Germany: more timely than ever
Zipfel, S., Herzog, W., Kruse, J., & Henningsen, P. (2016) · Psychotherapy and Psychosomatics · doi:10.1159/000447701 · Cited by 2,323 · see citing works
The interplay between the intestinal microbiota and the brain
Collins, S. M., Surette, M., & Bercik, P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2876 · Cited by 1,611 · cited 1× · see citing works
“Furthermore, there is an evidence that the microbiota influences brain function and the behaviour of the host by communicating with the brain via the gut-brain axis [41, 42].”
BackgroundReciprocal interactions of the intestinal microbiota and immune system
Maynard, C. L., Elson, C. O., Hatton, R. D., & Weaver, C. T. (2012) · Nature · doi:10.1038/nature11551 · Cited by 1,598 · cited 1× · see citing works
“It consists of mesenteric lymph nodes, Peyer’s patches, lymphocytes located in the intestinal lamina propria and large numbers of IgA plasmablasts located in the epithelium [28-30].”
BackgroundHow informative is the mouse for human gut microbiota research?
Nguyen, T. L. A., Vieira-Silva, S., Liston, A., & Raes, J. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.017400 · Cited by 1,334 · cited 1× · see citing works
“Additionally we have to consider that, at least for mice and humans, the Firmicutes to Bacteroidetes ratio should not be compared since it is well known that both species harbor a very different faecal microbial community in terms of composition and function [74].”
BackgroundGut Microbiomes of Malawian Twin Pairs Discordant for Kwashiorkor
Smith, M. I., Yatsunenko, T., Manary, M. J., Trehan, I., Mkakosya, R., Cheng, J., Kau, A. L., Rich, S. S., Concannon, P., Mychaleckyj, J. C., et al. (2013) · Science · doi:10.1126/science.1229000 · Cited by 1,173 · see citing works
Ze, X., Duncan, S. H., Louis, P., & Flint, H. J. (2012) · The ISME Journal · doi:10.1038/ismej.2012.4 · Cited by 1,060 · see citing works
The immune geography of IgA induction and function
Macpherson, A. J., McCoy, K. D., Johansen, F.-E., & Brandtzaeg, P. (2007) · Mucosal Immunology · doi:10.1038/mi.2007.6 · Cited by 1,047 · see citing works
Vandeputte, D., Falony, G., Vieira-Silva, S., Tito, R. Y., Joossens, M., & Raes, J. (2016) · Gut · doi:10.1136/gutjnl-2015-309618 · Cited by 1,028 · see citing works
Bacteria, Colonic Fermentation, and Gastrointestinal Health
Macfarlane, G. T., & Macfarlane, S. (2012) · Journal of AOAC INTERNATIONAL · doi:10.5740/jaoacint.sge_macfarlane · Cited by 970 · see citing works
Armougom, F., Henry, M., Vialettes, B., Raccah, D., & Raoult, D. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007125 · Cited by 905 · see citing works
Guinane, C. M., & Cotter, P. D. (2013) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x13482996 · Cited by 846 · see citing works
New insights into symptoms and neurocircuit function of anorexia nervosa
Kaye, W. H., Fudge, J. L., & Paulus, M. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2682 · Cited by 843 · see citing works
Roseburia Spp.: A Marker of Health?
Tamanai‐Shacoori, Z., Smida, I., Bousarghin, L., Loréal, O., Meuric, V., Fong, S. B., Bonnaure‐Mallet, M., & Jolivet‐Gougeon, A. (2017) · Future Microbiology · doi:10.2217/fmb-2016-0130 · Cited by 751 · see citing works
Kynurenine pathway metabolism and the microbiota-gut-brain axis
Kennedy, P. J., Cryan, J. F., Dinan, T. G., & Clarke, G. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.07.002 · Cited by 724 · see citing works
The human gut microbiome: ecology and recent evolutionary changes
Walter, J., & Ley, R. (2011) · Annual Review of Microbiology · doi:10.1146/annurev-micro-090110-102830 · Cited by 720 · see citing works
New concepts in the generation and functions of IgA
Pabst, O. (2012) · Nature reviews. Immunology · doi:10.1038/nri3322 · Cited by 656 · see citing works
Looking for a Signal in the Noise: Revisiting Obesity and the Microbiome
Sze, M. A., & Schloss, P. D. (2016) · mBio · doi:10.1128/mbio.01018-16 · Cited by 600 · see citing works
Chivers, D. J., & Hladik, C. M. (1980) · Journal of Morphology · doi:10.1002/jmor.1051660306 · Cited by 593 · see citing works
Long-term prognosis in anorexia nervosa: lessons from a 21-year follow-up study
Zipfel, S., Löwe, B., Reas, D. L., Deter, H.-C., & Herzog, W. (2000) · The Lancet · doi:10.1016/s0140-6736(99)05363-5 · Cited by 524 · see citing works
The microbiota-gut-brain axis in obesity.
Torres-Fuentes, C., Schellekens, H., Dinan, T., & Cryan, J. (2017) · The Lancet Gastroenterology and Hepatology · doi:10.1016/s2468-1253(17)30147-4 · Cited by 506 · see citing works
Queipo-Ortuño, M. I., Seoane, L. M., Murri, M., Pardo, M., Gomez-Zumaquero, J. M., Cardona, F., Casanueva, F., & Tinahones, F. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065465 · Cited by 497 · see citing works
Neuropeptides and the Microbiota-Gut-Brain Axis
Holzer, P., & Farzi, A. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_9 · Cited by 451 · see citing works
Consequences of tropical land use for multitrophic biodiversity and ecosystem functioning
Barnes, A. D., Jochum, M., Mumme, S., Haneda, N. F., Farajallah, A., Widarto, T. H., & Brose, U. (2014) · Nature Communications · doi:10.1038/ncomms6351 · Cited by 424 · see citing works
A metagenomic insight into our gut's microbiome
Lepage, P., Leclerc, M., Joossens, M., Mondot, S., Blottière, H. M., Raes, J., Ehrlich, S. D., & Dore, J. M. (2012) · Gut · doi:10.1136/gutjnl-2011-301805 · Cited by 371 · see citing works
The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos
Sommer, F., Ståhlman, M., Ilkayeva, O., Arnemo, J. M., Kindberg, J., Josefsson, J., Newgard, C. B., Fröbert, O., & Bäckhed, F. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.026 · Cited by 370 · see citing works
Human Colonic Microbiota: Ecology, Physiology and Metabolic Potential of Intestinal Bacteria
Macfarlane, G. T., & Macfarlane, S. (1997) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.1997.11720708 · Cited by 342 · see citing works
The intestinal microbiome of fish under starvation
Xia, J., Lin, G., Fu, G. H., Wan, Z. Y., Lee, M., Wang, L., Liu, X., & Yue, G. H. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-266 · Cited by 322 · see citing works
Mack, I., Cuntz, U., Grämer, C., Niedermaier, S., Pohl, C., Schwiertz, A., Zimmermann, K., Zipfel, S., Enck, P., & Penders, J. (2016) · Scientific Reports · doi:10.1038/srep26752 · Cited by 313 · see citing works
Self-citationKleiman, S. C., Watson, H. J., Bulik-Sullivan, E. C., Huh, E. Y., Tarantino, L. M., Bulik, C. M., & Carroll, I. M. (2015) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000247 · Cited by 303 · see citing works
Postprandial remodeling of the gut microbiota in Burmese pythons
Costello, E. K., Gordon, J. I., Secor, S. M., & Knight, R. D. (2010) · The ISME Journal · doi:10.1038/ismej.2010.71 · Cited by 267 · see citing works
Borgo, F., Riva, A., Benetti, A., Casiraghi, M. C., Bertelli, S., Garbossa, S., Anselmetti, S., Scarone, S., Pontiroli, A. E., Morace, G., et al. (2017) · PLOS ONE · doi:10.1371/journal.pone.0179739 · Cited by 267 · see citing works
Kohl, K. D., Amaya, J., Passement, C. A., Dearing, M. D., & McCue, M. D. (2014) · FEMS Microbiology Ecology · doi:10.1111/1574-6941.12442 · Cited by 249 · see citing works
Seasonal restructuring of the ground squirrel gut microbiota over the annual hibernation cycle
Carey, H. V., Walters, W. A., & Knight, R. D. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00387.2012 · Cited by 242 · see citing works
Categorization of the gut microbiota: enterotypes or gradients?
Jeffery, I. B., Claesson, M. J., O'Toole, P. W., & Shanahan, F. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2859 · Cited by 238 · see citing works
Gut Dysbiosis in Patients with Anorexia Nervosa
Morita, C., Tsuji, H., Hata, T., Gondo, M., Takakura, S., Kawai, K., Yoshihara, K., Ogata, K., Nomoto, K., Miyazaki, K., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0145274 · Cited by 238 · see citing works
Peptide YY(1-36) and Peptide YY(3-36): Part I. Distribution, Release and Actions
Ballantyne, G. H. (2006) · Obesity Surgery · doi:10.1381/096089206776944959 · Cited by 205 · see citing works
Ruminococcus champanellensis sp. nov., a cellulose-degrading bacterium from human gut microbiota
Chassard, C., Delmas, E., Céline Robert, Lawson, P. A., & Bernalier‐Donadille, A. (2011) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.027375-0 · Cited by 190 · see citing works
Response of Gut Microbiota to Fasting and Hibernation in Syrian Hamsters
Sonoyama, K., Fujiwara, R., Takemura, N., Ogasawara, T., Watanabe, J., Ito, H., & Morita, T. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.00692-09 · Cited by 189 · see citing works
Modulation of the gut microbiome: a systematic review of the effect of bariatric surgery
Guo, Y. H., Huang, Z., Liu, C., Qi, L., Sheng, Y., & Zou, D. (2017) · European Journal of Endocrinology · doi:10.1530/eje-17-0403 · Cited by 179 · see citing works
Changes in the Intestinal Microbiota of Wild Atlantic cod Gadus morhua L. Upon Captive Rearing
Dhanasiri, A. K. S., Brunvold, L., Brinchmann, M. F., Korsnes, K., Bergh, Ø., & Kiron, V. (2010) · Microbial Ecology · doi:10.1007/s00248-010-9673-y · Cited by 176 · see citing works
A refined palate: Bacterial consumption of host glycans in the gut
Marcobal, A. M., Southwick, A. M., Earle, K. A., & Sonnenburg, J. L. (2013) · Glycobiology · doi:10.1093/glycob/cwt040 · Cited by 172 · see citing works
Gut microbiota interacts with brain microstructure and function
Fernandez-Real, J.-M., Serino, M., Blasco, G., Puig, J., Daunis-i-Estadella, J., Ricart, W., Burcelin, R., Fernández-Aranda, F., & Portero-Otin, M. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-3076 · Cited by 167 · see citing works
Intestinal Microbiota and its Role in Irritable Bowel Syndrome (IBS)
Öhman, L., & Simrén, M. (2013) · Current Gastroenterology Reports · doi:10.1007/s11894-013-0323-7 · Cited by 123 · see citing works
Stevenson, T. J., Duddleston, K. N., & Buck, C. L. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.01537-14 · Cited by 112 · see citing works
Aging in Germ-free Mice: Life Tables and Lesions Observed at Natural Death
Gordon, H. A., Bruckner-Kardoss, E., & Wöstmann, B. S. J. (1966) · Journal of Gerontology · doi:10.1093/geronj/21.3.380 · Cited by 98 · see citing works
Obesity and the gut microbiome: Striving for causality
Harley, I. T. W., & Karp, C. L. (2012) · Molecular Metabolism · doi:10.1016/j.molmet.2012.07.002 · Cited by 96 · see citing works
Dill‐McFarland, K. A., Neil, K. L., Zeng, A., Sprenger, R. J., Kurtz, C. C., Suen, G., & Carey, H. V. (2014) · Molecular Ecology · doi:10.1111/mec.12884 · Cited by 91 · see citing works
Weng, F. C.-H., Yang, Y., & Wang, D. (2016) · BMC Genomics · doi:10.1186/s12864-016-3318-6 · Cited by 73 · see citing works
Influence of Fasting during Moult on the Faecal Microbiota of Penguins
Dewar, M., Arnould, J. P. Y., Krause, L., Trathan, P. N., Dann, P., & Smith, S. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099996 · Cited by 57 · see citing works
Gut Microbiota and Host Metabolism: What Relationship
Mithieux, G. (2017) · Neuroendocrinology · doi:10.1159/000484526 · Cited by 53 · see citing works
Gut microeukaryotes during anorexia nervosa: a case report
Gouba, N., Raoult, D., & Drancourt, M. (2014) · BMC Research Notes · doi:10.1186/1756-0500-7-33 · Cited by 49 · see citing works
Kleiman, S. C., Glenny, E. M., Bulik‐Sullivan, E. C., Huh, E. Y., Tsilimigras, M. C. B., Fodor, A. A., Bulik, C. M., & Carroll, I. M. (2017) · European Eating Disorders Review · doi:10.1002/erv.2524 · Cited by 49 · see citing works
Chen, J., Toyomasu, Y., Hayashi, Y., Linden, D. R., Szurszewski, J. H., Nelson, H., Farrugia, G., Kashyap, P., Chia, N., & Ördög, T. (2016) · Genome Medicine · doi:10.1186/s13073-016-0357-1 · Cited by 30 · see citing works
Banas, J. A., Loesche, W. J., & Nace, G. W. (1988) · Applied and Environmental Microbiology · doi:10.1128/aem.54.9.2305-2310.1988 · Cited by 29 · see citing works
Growth rate of male germfree Wistar rats fed ad libitum or restricted natural ingredient diet.
Dl, S., & Bs, W. (1987) · PubMed · Cited by 27 · see citing works
Starvation of marine flounder, squid and laboratory mice and its effect on the intestinal microbiota
Conway, P. L., Maki, J. S., Mitchell, R., & Kjelleberg, S. J. (1986) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1986.tb01728.x · Cited by 26 · see citing works
Response of intestinal flora of laboratory-reared leopard frogs (Rana pipiens) to cold and fasting
Gossling, J., Loesche, W. J., & Nace, G. W. (1982) · Applied and Environmental Microbiology · doi:10.1128/aem.44.1.67-71.1982 · Cited by 25 · see citing works
Training Courses Based on the New Maudsley Model, for Specialised Teams in Emilia Romagna, Italy
Stefanini, M. C., Troiani, M. R., Gentili, C. C., & Stani, M. D. (2016) · Florence Research (University of Florence) · doi:10.1002/erv · Cited by 23 · see citing works
Effect of Hibernation on the Intestinal Flora
Barnes, E. M. (1970) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/23.11.1519 · Cited by 12 · see citing works
Waxler, G. L., & Drees, D. T. (1972) · PubMed · Cited by 11 · see citing works
Changes in body composition of germ-free and conventional chickens during starvation
Hiro-Omi, Y., Hisae, M., & Furuse, M. (1992) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(92)90290-7 · Cited by 11 · see citing works
Germfree guinea pig delivery by hysterectomy.
Jj, L., Yerasimides, T. G., Jh, G., & Bausor, S. C. (1960) · PubMed · Cited by 10 · see citing works
YAMANAKA, M., Nomura, T., TOKIOKA, J., & Kametaka, M. (1980) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.26.435 · Cited by 5 · see citing works
(2014) · Institutional Repository University of Antioquia (University of Antioquia) · doi:10.1371/journal.pone
Flagged first, then by citations
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Sorted by citations
Meeting the review family: exploring review types and associated information retrieval requirements
Sutton, A., Clowes, M., Preston, L., & Booth, A. (2019) · Health Information & Libraries Journal · doi:10.1111/hir.12276 · Cited by 570 · see citing works
Mohr, A. E., Jäger, R., Carpenter, K. C., Kerksick, C. M., Purpura, M., Townsend, J. R., West, N. P., Black, K., Gleeson, M., Pyne, D. B., et al. (2020) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00353-w · Cited by 378 · see citing works
“being characterized by heterogeneity in the methodology and small sample sizes (for review see: [167]).”
BackgroundThe Neurobiology of Eating Disorders
Frank, G., Shott, M. E., & DeGuzman, M. C. (2019) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2019.05.007 · Cited by 155 · see citing works
The Microbiome and Eating Disorders
Seitz, J., Trinh, S., & Herpertz‐Dahlmann, B. (2018) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2018.10.004 · Cited by 93 · see citing works
Lodovico, L. D., Mondot, S., Dore, J. M., Mack, I., Hanachi, M., & Gorwood, P. A. P. M. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110114 · Cited by 92 · see citing works
Self-citationSchulz, N., Belheouane, M., Dahmen, B., Ruan, V., Specht, H. E., Dempfle, A., Herpertz‐Dahlmann, B., Baines, J. F., & Seitz, J. (2020) · International Journal of Eating Disorders · doi:10.1002/eat.23435 · Cited by 88 · see citing works
A systematic review on the role of microbiota in the pathogenesis and treatment of eating disorders
Carbone, E. A., D'Amato, P., Vicchio, G., Fazio, P. D., & Segura‐Garcìa, C. (2020) · European Psychiatry · doi:10.1192/j.eurpsy.2020.109 · Cited by 90 · see citing works
Gut microbiota predicts body fat change following a low-energy diet: a PREVIEW intervention study
Jian, C., Silvestre, M. P., Middleton, D., Korpela, K., Jalo, E., Broderick, D. T. J., de Vos, W. M., Fogelholm, M., Taylor, M. W., Raben, A., et al. (2022) · Genome Medicine · doi:10.1186/s13073-022-01053-7 · Cited by 87 · see citing works
Fetissov, S. O., & Hökfelt, T. G. M. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.07.004 · Cited by 85 · see citing works
The gut microbiome in anorexia nervosa: relevance for nutritional rehabilitation
Ruusunen, A., Rocks, T., Jacka, F., & Loughman, A. (2019) · Psychopharmacology · doi:10.1007/s00213-018-5159-2 · Cited by 74 · see citing works
Riedlinger, C., Schmidt, G., Weiland, A., Stengel, A., Giel, K. E., Zipfel, S., Enck, P., & Mack, I. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00195 · Cited by 74 · see citing works
Self-citationRecent advances in modulating the microbiome
Quigley, E. M. M., & Gajula, P. (2020) · F1000Research · doi:10.12688/f1000research.20204.1 · Cited by 68 · see citing works
The Impact of Starvation on the Microbiome and Gut-Brain Interaction in Anorexia Nervosa
Seitz, J., Belheouane, M., Schulz, N., Dempfle, A., Baines, J. F., & Herpertz‐Dahlmann, B. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00041 · Cited by 55 · see citing works
Ayton, A. K., & Ibrahim, A. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuz089 · Cited by 52 · see citing works
Remodelling of the intestinal ecosystem during caloric restriction and fasting
Ducarmon, Q. R., Grundler, F., Maho, Y. L., de Toledo, F. W., Zeller, G., Habold, C., & Mesnage, R. (2023) · Trends in Microbiology · doi:10.1016/j.tim.2023.02.009 · Cited by 44 · see citing works
Insights into the role of intestinal microbiota in hematopoietic stem-cell transplantation
Zama, D., Bossù, G., Leardini, D., Muratore, E., Biagi, E., Prete, A., Pession, A., & Masetti, R. (2020) · Therapeutic Advances in Hematology · doi:10.1177/2040620719896961 · Cited by 44 · see citing works
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Seitz, J., Dahmen, B., Keller, L., & Herpertz‐Dahlmann, B. (2020) · Nutrients · doi:10.3390/nu12113295 · Cited by 37 · see citing works
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Ghenciulescu, A., Park, R. J., & Burnet, P. W. J. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.611677 · Cited by 42 · see citing works
Gröbner, E., Zeiler, M. D., Fischmeister, F. P. S., Kollndorfer, K., Schmelz, S., Schneider, A. E., Haid-Stecher, N., Sevecke, K., Wagner, G., Keller, L., et al. (2021) · European Eating Disorders Review · doi:10.1002/erv.2876 · Cited by 38 · see citing works
Gut microbiota disturbances and protein-energy wasting in chronic kidney disease: a narrative review
Martín-del-Campo, F., Avesani, C. M., Stenvinkel, P., Lindholm, B., Cueto-Manzano, A. M., & Cortés–Sanabria, L. (2023) · Journal of Nephrology · doi:10.1007/s40620-022-01560-1 · Cited by 31 · see citing works
A review of the impact of social disruptions on food security and food choice
Munialo, C. D., & Mellor, D. D. (2023) · Food Science & Nutrition · doi:10.1002/fsn3.3752 · Cited by 38 · see citing works
Rocks, T., West, M. L., Hockey, M., Aslam, H., Lane, M. M., Loughman, A., Jacka, F. N., & Ruusunen, A. A. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110201 · Cited by 29 · see citing works
Starvation and Its Effects on the Gut
Kelly, P. M. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa135 · Cited by 27 · see citing works
Neuroendocrine adaptations to starvation
Amorim, T., Khiyami, A. M., Latif, T., & Fazeli, P. K. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106365 · Cited by 26 · see citing works
Features of gut microbiota in patients with anorexia nervosa
Yuan, R., Yang, L., Yao, G., Geng, S., Ge, Q., Bo, S., & Li, X. (2022) · Chinese Medical Journal · doi:10.1097/cm9.0000000000002362 · Cited by 25 · see citing works
Applications of gut microbiota in patients with hematopoietic stem-cell transplantation
Yu, J., Sun, H., Cao, W., Han, L., Song, Y., Wan, D., & Jiang, Z. (2020) · Experimental Hematology & Oncology · doi:10.1186/s40164-020-00194-y · Cited by 25 · see citing works
Labarta-Bajo, L., Gramalla-Schmitz, A., Gerner, R. R., Kazane, K. R., Humphrey, G., Schwartz, T., Sanders, K., Swafford, A. D.-E., Knight, R. D., Raffatellu, M., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2003656117 · Cited by 24 · see citing works
Role of microbes in the pathogenesis of neuropsychiatric disorders
Goswami, A., Wendt, F. R., Pathak, G. A., Tylee, D. S., Angelis, F. D., Lillo, A. D., & Polimanti, R. A. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100917 · Cited by 20 · see citing works
Himmerich, H., Keeler, J. L., King, J. A., Ehrlich, S., Kaufmann, L., Bulik, C. M., Cohen‐Woods, S., Wade, T. D., Steiger, H., Booij, L., et al. (2026) · The World Journal of Biological Psychiatry · doi:10.1080/15622975.2026.2626934 · Cited by 22 · see citing works
Self-citationLiu, L., Poveda, C. G., Jenkins, P. E., & Walton, G. (2021) · Nutrients · doi:10.3390/nu13124447 · Cited by 19 · see citing works
Mohr, A. E., Jasbi, P., Wyst, K. B. V., van Woerden, I., Shi, X., Gu, H., Whisner, C. M., & Bruening, M. M. (2022) · Scientific Reports · doi:10.1038/s41598-022-18515-y · Cited by 19 · see citing works
Breton, J., Legrand, R., Achamrah, N., Chan, P., do Rego, J. L., do Rego, J. L., Coëffier, M., Déchelotte, P., & Fetissov, S. O. (2019) · Nutrition · doi:10.1016/j.nut.2019.110557 · Cited by 19 · see citing works
Cook, J., Lehne, C., Weiland, A., Archid, R., Ritze, Y., Bauer, K., Zipfel, S., Penders, J., Enck, P., & Mack, I. (2020) · Nutrients · doi:10.3390/nu12082396 · Cited by 19 · see citing works
Self-citationJowik, K., Tyszkiewicz‐Nwafor, M., & Słopień, A. (2021) · Nutrients · doi:10.3390/nu13113819 · Cited by 18 · see citing works
Breton, J., Jacquemot, J., Yaker, L., Leclerc, C., Connil, N., Feuilloley, M. G. J., Déchelotte, P., & Fetissov, S. O. (2020) · Microorganisms · doi:10.3390/microorganisms8040530 · Cited by 18 · see citing works
Diversity and Composition of Gut Bacterial Community in Giant Panda with Anorexia
Zhao, S., Li, C., Zhu, T., Jin, L., Deng, W., Zhao, K., He, Y., Li, G., Xiong, Y., Li, T., et al. (2021) · Current Microbiology · doi:10.1007/s00284-021-02424-w · Cited by 17 · see citing works
Riedlinger, C., Mazurak, N., Schäffeler, N., Stengel, A., Giel, K. E., Zipfel, S., Enck, P., & Mack, I. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.962837 · Cited by 16 · see citing works
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Trinh, S., Kogel, V., Kneisel, L., Müller-Limberger, E., Herpertz‐Dahlmann, B., Beyer, C., & Seitz, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119496 · Cited by 15 · see citing works
Bruchhage, K., Lupatsii, M., Möllenkolk, F., Leffers, D., Kurabi, A., Jürgens, T. P., Graspeuntner, S., Hollfelder, D., & Leichtle, A. (2023) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-022-07795-9 · Cited by 14 · see citing works
Ketel, J., Bruguera, M. B., Auchter, G., Cuntz, U., Zipfel, S., Enck, P., & Mack, I. (2024) · Nutrients · doi:10.3390/nu16060891 · Cited by 11 · see citing works
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Riehl, M. E., & Scarlata, K. (2021) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2021.03.001 · Cited by 14 · see citing works
Zhu, R., Tian, P., Zhang, H., Wang, G., & Chen, W. (2022) · Neuropharmacology · doi:10.1016/j.neuropharm.2022.109315 · Cited by 11 · see citing works
Norris, M. L. (2024) · European Eating Disorders Review · doi:10.1002/erv.3114 · Cited by 9 · see citing works
Anorexia Nervosa and Autism Spectrum Disorders: Future Hopes Linked to Mucosal Immunity
Gabriel-Segard, T., Paul, S., Berger, A., & Massoubre, C. (2019) · NeuroImmunoModulation · doi:10.1159/000502997 · Cited by 9 · see citing works
The gut microbiome in anorexia nervosa
Hildebrandt, T., & Peyser, D. (2023) · Nature Microbiology · doi:10.1038/s41564-023-01372-4 · Cited by 8 · see citing works
Dysbiosis of gut microbiota during fecal stream diversion in patients with colorectal cancer
Lee, S. Y., Park, H.-M., Kim, C. H., & Kim, H. R. (2023) · Gut Pathogens · doi:10.1186/s13099-023-00566-9 · Cited by 7 · see citing works
Rousseau, L., Salaün, C., Langlois, L. D., Achamrah, N., & Coëffier, M. (2025) · Clinical Nutrition · doi:10.1016/j.clnu.2025.07.002 · Cited by 5 · see citing works
Psychobiology of Eating Disorders – a Gateway to Precision Medicine
Zipfel, S., & Schmidt, U. H. (2018) · Current Neuropharmacology · doi:10.2174/1570159x1608180821144325 · Cited by 5 · see citing works
Bi, X., Liu, Y., Lu, Y., Ling, L., Lü, J., Hu, C., & Ding, W. Q. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1270690 · Cited by 4 · see citing works
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Seitz, J., Keller, L., Trinh, S., & Herpertz‐Dahlmann, B. (2020) · Der Nervenarzt · doi:10.1007/s00115-020-01003-x · Cited by 4 · see citing works
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Trinh, S., Herpertz‐Dahlmann, B., & Seitz, J. (2020) · Nervenheilkunde · doi:10.1055/a-1037-2119 · Cited by 3 · see citing works
Gut Microbiome in Stress-related Disorders: The New Approaches to Neuroinflamation syndrome
Халтурина, Е. О., Klyueva, L. A., Boshiyan, R. E., Zembatov, G. M., & Alimova, A. M. (2022) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-196-12-74-82 · Cited by 2 · see citing works
Trinh, S., Keller, L., Herpertz‐Dahlmann, B., & Seitz, J. (2023) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024/1422-4917/a000928 · Cited by 2 · see citing works
Meher, M. M., Afrin, M., Jahan, M. R., Yanai, A., & Islam, M. N. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-11347-9 · Cited by 1 · see citing works
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Seitz, J., Baines, J. F., & Herpertz‐Dahlmann, B. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-54852-6.00014-8 · Cited by 1 · see citing works
Dysbioza mikrobiomu jelitowego w anoreksji psychicznej
Janczy, A., Landowska, M., & Kochan, Z. (2021) · Postępy Higieny i Medycyny Doświadczalnej · doi:10.5604/01.3001.0014.8601 · Cited by 1 · see citing works
Dysbiosis of the Microbiota in Anorexia Nervosa: Pathophysiological Implications
Sjögren, M., Frostad, S., & Barfod, K. K. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.85253 · Cited by 1 · see citing works
Mikrobiom und Inflammation bei Adipositas
Mack, I. (2022) · Springer eBooks · doi:10.1007/978-3-662-63544-5_60 · Cited by 1 · see citing works
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O’Halloran, M. S., & Jones, L. K. (2025) · Oxford University Press eBooks · doi:10.1093/oso/9780197687833.003.0011 · Cited by 1 · see citing works
Microbiome and Inflammation in Obesity
Mack, I. (2024) · Springer eBooks · doi:10.1007/978-3-662-67662-2_60
Self-citationAyton, A. K. (2024) · Cambridge University Press eBooks · doi:10.1017/9781911623861.027
Microbiota-Gut-Brain Axis and ED
Mack, I., & Seitz, J. (2024) · Springer eBooks · doi:10.1007/978-3-030-97416-9_43-1
Self-citationMicrobiota-Gut-Brain Axis and ED
Mack, I., & Seitz, J. (2024) · Springer eBooks · doi:10.1007/978-3-031-46096-8_43
Self-citationBibliometric Analysis of Studies on “Probiotics and Prebiotics” With VOSviewer
Can, S., & Can, H. (2025) · IGI Global eBooks · doi:10.4018/979-8-3693-8699-6.ch007
Jegodzinski, L., & Meyhöfer, S. M. (2024) · Springer Reference Medizin · doi:10.1007/978-3-642-54676-1_277-1
The Microbiome–Gut–Brain Axis in Anorexia Nervosa
Seitz, J., & Trinh, S. (2025) · Oxford University Press eBooks · doi:10.1093/9780197675212.003.0025
Lee, S. Y., Park, H.-M., Kim, C. H., & Kim, H. R. (2023) · Figshare · doi:10.6084/m9.figshare.23993394
Lee, S. Y., Park, H.-M., Kim, C. H., & Kim, H. R. (2023) · Figshare · doi:10.6084/m9.figshare.23993388
Lee, S. Y., Park, H.-M., Kim, C. H., & Kim, H. R. (2023) · Figshare · doi:10.6084/m9.figshare.23993397
Lee, S. Y., Park, H.-M., Kim, C. H., & Kim, H. R. (2023) · Figshare · doi:10.6084/m9.figshare.23993382
Jian, C., Silvestre, M. P., Middleton, D., Korpela, K., Jalo, E., Broderick, D., de Vos, W. M., Fogelholm, M., Taylor, M. W., Raben, A., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19817910
Jian, C., Silvestre, M. P., Middleton, D., Korpela, K., Jalo, E., Broderick, D. T. J., de Vos, W. M., Fogelholm, M., Taylor, M. W., Raben, A., et al. (2022) · Figshare · doi:10.6084/m9.figshare.19817904
Lee, S. Y., Park, H.-M., Kim, C. H., & Kim, H. R. (2023) · Figshare · doi:10.6084/m9.figshare.23993391
Lee, S. Y., Park, H.-M., Kim, C. H., & Kim, H. R. (2023) · Figshare · doi:10.6084/m9.figshare.23993385
Gabriel-Segard, T. (2023) · theses.fr (ABES) · doi:10.70675/2f469c9fz7a22z4f47z9e37zcf0e1f890660
Ecological Drivers of Microbiota Diversity in the Pharmacophagous Turnip Sawfly
Singh, P., Dirksen, P., Kaltenpoth, M., & Müller, C. (2026) · Environmental Microbiology · doi:10.1111/1462-2920.70309
Dey, P. (2026) · Nutrition Research · doi:10.1016/j.nutres.2026.10.009
- Authors
- Mack, I., Penders, J., Cook, J., Dugmore, J., Mazurak, N., & Enck, P.
- Affiliations
- Universitätsklinikum Tübingen (DE)
- Maastricht University Medical Centre (NL)
- The University of Queensland (AU)
- Corresponding author
- Mack, Isabelle
- Venue
- Current Neuropharmacology
- Publisher
- Bentham Science Publishers Ltd.
- Published
- 2018-08-21
- Volume
- 16
- Issue
- 8
- Pages
- 1131-1149
- ISSN
- 1570-159X (ISSN-L)
- PMC
- PMC6187755
- OpenAlex
- W2782854026
- Semantic Scholar
- 0be033d82bbede56263e24cc345c5afee9bf28a2
- Cited by
- 79
- References
- 87
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 9 · 2023: 17 · 2022: 9 · 2021: 8 · 2020: 16 · 2019: 9 · 2018: 3
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Current Neuropharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Funders
- Schweizerische Anorexia Nervosa Stiftung (32-13)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- anorexia nervosa, gut microbiota, starvation, fasting, refeeding, eating disorders, hibernation, microbial diversity, microbial richness, microbial community structure
- MeSH terms
- Gastrointestinal Microbiome, Animals, Anorexia Nervosa, Humans, Starvation
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