Dose-response relationship between plasma oxytocin and cortisol and adrenocorticotropin concentrations during oxytocin infusion in normal men
Abstract
We previously demonstrated that acute injection of a pharmacological dose of oxytocin (2 IU) in humans decreased the concentrations of ACTH and cortisol, a neuroendocrine action opposite that of vasopressin. In the present work the effect of continuous infusion of lower doses of oxytocin was tested. Plasma oxytocin was also measured using an oxytocin RIA to study the dose-response relation. Infusion of oxytocin (8 mIU/min for 30 min) resulted in a plasma oxytocin level of 9.9 +/- 1.4 (+/- SD) muIU/ml and induced a decrease in the plasma concentration of ACTH in three of four normal subjects. Infusion of oxytocin at the rate of 16 mIU/ml for 30 min resulted in plasma oxytocin level of 17.7 +/- 1.6 muIU/ml and decreases in plasma ACTH and cortisol concentrations in all six subjects tested. Increasing the oxytocin dose from 32 to 64 and 128 mIU/min for three additional 30-min periods induced more pronounced decreases in plasma ACTH and cortisol. In each subject, there was a highly significant inverse relationship between plasma oxytocin, and ACTH and cortisol (r = -0.85 to -0.99). During saline infusion, a significant inverse relationship with a 10-min lag period between plasma oxytocin and ACTH (r = -0.55) was found in only one of six subjects. These data demonstrate that infusion of exogenous oxytocin leading to plasma levels approximately 10 times higher than normal induced consistent decreases in corticotropic function. Because the oxytocin concentration in portal blood is approximately 300 times higher than that in peripheral blood, it is likely that the inhibitory action of oxytocin on ACTH secretion is of physiological significance.
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Activation of systemic OT receptors in the adrenal cortex suppresses cortisol release.
“whose activation suppresses cortisol release (Chiodera and Legros, 1981; Legros et al., 1984; de Oliveira et al., 2007; Stachowiak et al., 1995)”
From Parallel social information processing circuits are differentially impacted in autism (2020) · cites this paper as Legros et al., 1984
Dose-dependent oxytocin efficacy has been shown in animal and human studies on diseases other than autism spectrum disorder.
“Previous animal14, 15 and human studies on diseases other than ASD16, 17, 18 have shown dose-dependent oxytocin efficacy.”
From Oxytocin efficacy is modulated by dosage and oxytocin receptor genotype in young adults with high-functioning autism: a 24-week randomized clinical trial (2016) · cites this paper as [16]
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- Authors
- LEGROS, J. J., CHIODERA, P., GEENEN, V., SMITZ, S., & FRENCKELL, R. V.
- Affiliations
- University of Parma (IT)
- ORCID
- GEENEN, V.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1984-01
- Volume
- 58
- Issue
- 1
- Pages
- 105-109
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2031133459
- Cited by
- 89
- References
- 7
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 3 · 2021: 4 · 2020: 3 · 2018: 4 · 2017: 3 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 6 · 2012: 3
- FWCI
- 4.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, ACTH, cortisol, dose-response relationship, neuroendocrine regulation, vasopressin, hypothalamic-pituitary-adrenal axis, plasma oxytocin
- MeSH terms
- Adrenocorticotropic Hormone, Adult, Dose-Response Relationship, Drug, Humans, Hydrocortisone, Infusions, Parenteral, Male, Oxytocin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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