Oxytocin response to an experimental psychosocial challenge in adults exposed to traumatic experiences during childhood or adolescence

Pierrehumbert, B.; Torrisi, R.; Laufer, D.; Halfon, O.; Ansermet, F.; Beck Popovic, M.

doi:10.1016/j.neuroscience.2009.12.016

Cited by 139Neuroendocrine regulation and behaviorStress Responses and CortisolChild Abuse and Trauma

Oxytocin response to an experimental psychosocial challenge in adults exposed to traumatic experiences during childhood or adolescence

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Pierrehumbert, B., Torrisi, R., Laufer, D., Halfon, O., Ansermet, F., Beck Popovic, M.·2010·Neuroscience

DOI 10.1016/j.neuroscience.2009.12.016

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Abstract

Long-term implications of the exposure to traumatizing experiences during childhood or adolescence, such as sexual abuse, or cancer, have been documented, namely the subjects' response to an acute stress in adulthood. Several indicators of the stress response have been considered (e.g. cortisol, heart rate). Oxytocin (OT) response to an acute stress of individuals exposed to trauma has not been documented. Eighty subjects (n=26 women who had experienced episodes of child abuse, n=25 men and women healthy survivors of cancer in childhood or adolescence, and 29 controls) have been submitted to a laboratory session involving an experimental stress challenge, the Trier social stress test. Overall, there was a clear OT response to the psychosocial challenge. Subjects having experienced a childhood/adolescence life-threatening illness had higher mean levels of OT than both abused and control subjects. There was a moderate negative relationship between OT and salivary cortisol. It is suggested that an acute stress stimulates OT secretion, and that the exposure to enduring life-threatening experiences in childhood/adolescence has long-lasting consequences regarding the stress system and connected functions, namely the activation of OT secretion. Better knowledge of such long-term implications is important so that to prevent dysregulations of the stress responses, which have been shown to be associated to the individual's mental health.

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Potential sample-matrix interference did not corrupt the oxytocin results.
“the facts that the levels were still much lower than those documented with the criticized assays and, moreover, showed a positive association with stress (Fig. 2c, d), as expected from the extrapolation of previously published data [52], strongly suggest that a potential sample-matrix interference, if existent at all, did not corrupt our results.”
From Intranasal oxytocin reduces provoked symptoms in female patients with posttraumatic stress disorder despite exerting sympathomimetic and positive chronotropic effects in a randomized controlled trial (2017) · cites this paper as [52]

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Authors: Pierrehumbert, B., Torrisi, R., Laufer, D., Halfon, O., Ansermet, F., & Beck Popovic, M.
Affiliations: Centre Hospitalier Universitaire Vaudois (CH)
University Hospital of Geneva (CH)
Corresponding author: Pierrehumbert, B.
ORCID: Pierrehumbert, B.
Ansermet, F.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2010-03
Volume: 166
Issue: 1
Pages: 168-177
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2009.12.016
OpenAlex: W2082515243
Semantic Scholar: 3b9778c04e60abe1dbc21af26b83d9569c290e90
Cited by: 139
References: 90
Citations by year: 2026: 3 · 2025: 7 · 2024: 7 · 2023: 1 · 2022: 9 · 2021: 14 · 2020: 4 · 2019: 10 · 2018: 11 · 2017: 14 · 2016: 14 · 2015: 12 · 2014: 12 · 2013: 9 · 2012: 4
FWCI: 5.22
Type: journal article
Language: en
Open access: green
archive-ouverte.unige.ch
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Archive ouverte UNIGE (University of Geneva) (submittedVersion)
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Keywords: oxytocin, childhood trauma, adolescent trauma, acute stress response, Trier Social Stress Test, salivary cortisol, child abuse, childhood cancer survivors, life-threatening illness, psychosocial stress, long-term consequences of trauma
MeSH terms: Acute Disease, Adolescent, Adult, Aging, Child, Child Abuse, Sexual, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Middle Aged, Neoplasms, Neuropsychological Tests, Oxytocin, Psychology, Sex Characteristics, Sex Factors, Stress Disorders, Post-Traumatic, Stress, Psychological, Time, Mood Disorders, Young Adult

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Oxytocin response to an experimental psychosocial challenge in adults exposed to traumatic experiences during childhood or adolescence

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