ACTH receptor, CYP11A1, CYP17 and CYP21A2 genes are expressed in skin.

The Molecular Biology, Biochemistry, and Physiology of Human Steroidogenesis and Its Disorders

Miller, W. L., & Auchus, R. J. (2011) · Endocrine Reviews · doi:10.1210/er.2010-0013 · Cited by 2,458

Melanin pigmentation in mammalian skin and its hormonal regulation

Slominski, A., Tobin, D. J., Shibahara, S., & Wortsman, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00044.2003 · Cited by 2,015

Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress

Slominski, A., Wortsman, J., Luger, T., Paus, R., & Solomon, S. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.979 · Cited by 776

Human hair follicles display a functional equivalent of the hypothalamic‐pituitary‐adrenal (HPA) axis and synthesize cortisol

Ito, N., Ito, T., Kromminga, A., Bettermann, A., Takigawa, M., Kees, F., Straub, R. H., & Paus, R. (2005) · The FASEB Journal · doi:10.1096/fj.04-1968fje · Cited by 498

Untitled work

Slominski (2012) · doi:10.1007/978-3-642-19683-6_1 · Cited by 461

Key role of CRF in the skin stress response system

Slominski, A. T., Zmijewski, M. A., Zbytek, B., Tobin, D. J., Theoharides, T. C., & Rivier, J. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1092 · Cited by 400

Steroidogenesis in the skin: Implications for local immune functions

Slominski, A., Zbytek, B., Nikolakis, G., Manna, P. R., Skobowiat, C., Zmijewski, M., Li, W., Janjetovic, Z., Postlethwaite, A., Zouboulis, C. C., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.02.006 · Cited by 369

Human skin is a steroidogenic tissue: steroidogenic enzymes and cofactors are expressed in epidermis, normal sebocytes, and an immortalized sebocyte cell line (SEB-1)

Thiboutot, D., Gilliland, K., Cong, Z., Jabara, S., McAllister, J. M., Sivarajah, A., & Clawson, G. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12244.x · Cited by 301

Extra-adrenal glucocorticoids and mineralocorticoids: evidence for local synthesis, regulation, and function

Taves, M. D., Gomez-Sanchez, C. E., & Soma, K. K. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00100.2011 · Cited by 293

Novel activities of CYP11A1 and their potential physiological significance

Slominski, A. T., Li, W., Kim, T.-K., Semak, I., Wang, J., Zjawiony, J. K., & Tuckey, R. C. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.11.010 · Cited by 292

Differential expression of HPA axis homolog in the skin

Slominski, A., Wortsman, J., Tuckey, R. C., & Paus, R. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.12.012 · Cited by 279

A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin

Slominski, A., Zjawiony, J., Wortsman, J., Semak, I., Stewart, J., Pisarchik, A., Sweatman, T., Marcos, J., Dunbar, C., & C. Tuckey, R. (2004) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.2004.04356.x · Cited by 243

CRH stimulation of corticosteroids production in melanocytes is mediated by ACTH

Slominski, A., Zbytek, B., Szczesniewski, A., Semak, I., Kaminski, J., Sweatman, T., & Wortsman, J. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00519.2004 · Cited by 211

Disorders in the initial steps of steroid hormone synthesis

Miller, W. L. (2017) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2016.03.009 · Cited by 205

Recent advances in the diagnosis and management of congenital adrenal hyperplasia due to 21-hydroxylase deficiency

Forest, M. G. (2004) · Human Reproduction Update · doi:10.1093/humupd/dmh047 · Cited by 200

The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions

Slominski, A. T., Kim, T.-K., Li, W., Yi, A.-K., Postlethwaite, A., & Tuckey, R. C. (2014) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.10.012 · Cited by 170

Corticotropin releasing hormone and the skin

Slominski, A. (2006) · Frontiers in bioscience · doi:10.2741/1966 · Cited by 157

Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity

Slominski, A. T., Janjetovic, Z., Fuller, B. E., Zmijewski, M. A., Tuckey, R. C., Nguyen, M. N., Sweatman, T., Li, W., Zjawiony, J., Miller, D., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009907 · Cited by 149

CRH stimulates POMC activity and corticosterone production in dermal fibroblasts

Slominski, A., Zbytek, B., Semak, I., Sweatman, T., & Wortsman, J. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.01.014 · Cited by 143

Potential mechanism of skin response to stress

SLOMINSKI, A., & MIHM, M. C. (1996) · International Journal of Dermatology · doi:10.1111/j.1365-4362.1996.tb05049.x · Cited by 115

Skin as an endocrine organ: implications for its function

Slominski, A., Wortsman, J., Paus, R., Elias, P. M., Tobin, D. J., & Feingold, K. R. (2008) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2008.04.004 · Cited by 116

60 YEARS OF POMC: Adrenal and extra-adrenal functions of ACTH

Gallo-Payet, N. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-15-0257 · Cited by 98

Steroid synthesis by primary human keratinocytes; implications for skin disease

Hannen, R. F., Michael, A. E., Jaulim, A., Bhogal, R., Burrin, J. M., & Philpott, M. P. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.11.059 · Cited by 96

Stress-linked cortisol concentrations in hair: what we know and what we need to know

Sharpley, C. F., McFarlane, J. R., & Slominski, A. (2012) · revneuro · doi:10.1515/rns.2011.058 · Cited by 92

The melanocortin receptors and their accessory proteins

Ramachandrappa, S., Gorrigan, R. J., Clark, A. J. L., & Chan, L. F. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00009 · Cited by 87

Cytochrome P450scc-dependent metabolism of 7-dehydrocholesterol in placenta and epidermal keratinocytes

Slominski, A. T., Kim, T.-K., Chen, J., Nguyen, M. N., Li, W., Yates, C. R., Sweatman, T., Janjetovic, Z., & Tuckey, R. C. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2012.07.027 · Cited by 81

Cutaneous glucocorticosteroidogenesis: securing local homeostasis and the skin integrity

Slominski, A. T., Manna, P. R., & Tuckey, R. C. (2014) · Experimental Dermatology · doi:10.1111/exd.12376 · Cited by 79

Novel non-calcemic secosteroids that are produced by human epidermal keratinocytes protect against solar radiation

Slominski, A. T., Janjetovic, Z., Kim, T.-K., Wasilewski, P., Rosas, S., Hanna, S., Sayre, R. M., Dowdy, J. C., Li, W., & Tuckey, R. C. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.01.014 · Cited by 77

Skin steroidogenesis in health and disease

Nikolakis, G., Stratakis, C. A., Kanaki, T., Slominski, A., & Zouboulis, C. C. (2016) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-016-9390-z · Cited by 76

Novel vitamin D photoproducts and their precursors in the skin

Slominski, A., Kim, T.-K., Zmijewski, M. A., Janjetovic, Z., Li, W., Chen, J., Kusniatsova, E. I., Semak, I., Postlethwaite, A., Miller, D. D., et al. (2013) · Dermato-Endocrinology · doi:10.4161/derm.23938 · Cited by 76

Cultured human dermal fibroblasts do produce cortisol

Slominski, A., Zbytek, B., Szczesniewski, A., & Wortsman, J. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700204 · Cited by 66

CYP11A1 in skin: an alternative route to photoprotection by vitamin D compounds

Tongkao-on, W., Carter, S., Reeve, V. E., Dixon, K. M., Gordon-Thomson, C., Halliday, G. M., Tuckey, R. C., & Mason, R. S. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2014.11.015 · Cited by 63

Sex steroid synthesis in human skin in situ: the roles of aromatase and steroidogenic acute regulatory protein in the homeostasis of human skin

Inoue, T., Miki, Y., Abe, K., Hatori, M., Hosaka, M., Kariya, Y., Kakuo, S., Fujimura, T., Hachiya, A., Honma, S., et al. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2012.05.005 · Cited by 62

Metabolism of progesterone to DOC, corticosterone and 18OHDOC in cultured human melanoma cells

Slominski, A., Gomez-Sanchez, C. E., Foecking, M. F., & Wortsman, J. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00889-3 · Cited by 60

Drug-induced and genetic alterations in stress-responsive systems: implications for specific addictive diseases

Zhou, Y., Proudnikov, D., Yuferov, V., & Kreek, M. J. (2010) · Brain Research · doi:10.1016/j.brainres.2009.11.015 · Cited by 58

Lumisterol is metabolized by CYP11A1: discovery of a new pathway

Tuckey, R. C., Slominski, A. T., Cheng, C. Y. S., Chen, J., Kim, T.-K., Xiao, M., & Li, W. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.08.004 · Cited by 43

Genetic variation of the cutaneous HPA axis: an analysis of UVB-induced differential responses

Skobowiat, C., Nejati, R., Lu, L., Williams, R. W., & Slominski, A. T. (2013) · Gene · doi:10.1016/j.gene.2013.08.035 · Cited by 42

Gas chromatography/mass spectrometry characterization of corticosteroid metabolism in human immortalized keratinocytes

Slominski, A., Wortsman, J., Foecking, M. F., Shackleton, C., Gomez-Sanchez, C., & Szczesniewski, A. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01648.x · Cited by 41

Higher Levels of Steroidogenic Acute Regulatory Protein and Type I 3β-Hydroxysteroid Dehydrogenase in the Scalp of Men with Androgenetic Alopecia

Chen, W., Tsai, S.-J., Liao, C.-Y., Tsai, R.-Y., Chen, Y.-J., Pan, B.-J., Hung, C.-L., & Zouboulis, C. C. (2006) · Journal of Investigative Dermatology · doi:10.1038/sj.jid.5700442 · Cited by 25

Role of microsomal steroid hydroxylases in Δ7-steroid biosynthesis

Sushko, T. A., Gilep, A. A., Yantsevich, A. V., & Usanov, S. A. (2013) · Biochemistry (Moscow) · doi:10.1134/s0006297913030103 · Cited by 10