Neurochemical regulation of sleep

Steiger, Axel

doi:10.1016/j.jpsychires.2006.04.007

Cited by 262Sleep and Wakefulness ResearchNeuropeptides and Animal PhysiologyCircadian rhythm and melatonin

Neurochemical regulation of sleep

Steiger, Axel·2007·Journal of Psychiatric Research

DOI 10.1016/j.jpsychires.2006.04.007

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Abstract

This review summarizes recent developments in the field of sleep regulation, particularly in the role of hormones, and of synthetic GABA(A) receptor agonists. Certain hormones play a specific role in sleep regulation. A reciprocal interaction of the neuropeptides growth hormone (GH)-releasing hormone (GHRH) and corticotropin-releasing hormone (CRH) plays a key role in sleep regulation. At least in males GHRH is a common stimulus of non-rapid-eye-movement sleep (NREMS) and GH and inhibits the hypothalamo-pituitary adrenocortical (HPA) hormones, whereas CRH exerts opposite effects. Furthermore CRH may enhance rapid-eye-movement sleep (REMS). Changes in the GHRH:CRH ratio in favor of CRH appear to contribute to sleep EEG and endocrine changes during depression and normal ageing. In women, however, CRH-like effects of GHRH were found. Besides CRH somatostatin impairs sleep, whereas ghrelin, galanin and neuropeptide Y promote sleep. Vasoactive intestinal polypeptide appears to be involved in the temporal organization of human sleep. Beside of peptides, steroids participate in sleep regulation. Cortisol appears to promote REMS. Various neuroactive steroids exert specific effects on sleep. The beneficial effect of estrogen replacement therapy in menopausal women suggests a role of estrogen in sleep regulation. The GABA(A) receptor or GABAergic neurons are involved in the action of many of these hormones. Recently synthetic GABA(A) agonists, particularly gaboxadol and the GABA reuptake inhibitor tiagabine were shown to differ distinctly in their action from allosteric modulators of the GABA(A) receptor like benzodiazepines as they promote slow-wave sleep, decrease wakefulness and do not affect REMS.

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Pregnancy causes significant changes in the neuroendocrine system, including gonadal steroids, pituitary hormones, melatonin, and cortisol.
“Pregnancy causes significant changes in the neuroendocrine system, including gonadal steroids (estrogen and progesterone), pituitary hormones (gonadatrophins, prolactin, and growth hormone), melatonin, and cortisol [52,53].”
From Non-Pharmacological Treatment of Insomnia (2012) · cites this paper as [52]

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Hemmeter, U., Rothe, B., Guldner, J., Holsboer, F., & Steiger, A. (1998) · Neuropsychobiology · doi:10.1159/000026513 · Cited by 25 · see citing works
The effect of SRIF on the EEG sleep of normal men
Kupfer, D. J., Jarrett, D. B., & Ehlers, C. L. (1992) · Psychoneuroendocrinology · doi:10.1016/0306-4530(92)90074-h · Cited by 25 · see citing works
Elevated Plasma Ghrelin Levels in Night-Eating Syndrome
Rosenhagen, M. C., Uhr, M., SCHÜSSLER, P., & Steiger, A. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.4.813 · Cited by 25 · see citing works
Sleep Endocrine Effects of the 11-β-Hydroxysteroiddehydrogenase Inhibitor Metyrapone
Jahn, H., Kiefer, F., Schick, M., Yassouridis, A., Steiger, A., Kellner, M. B., & Wiedemann, K. (2003) · SLEEP · doi:10.1093/sleep/26.7.823 · Cited by 24 · see citing works
High doses of systemic DHEA-sulfate do not affect sleep structure and elicit moderate changes in non-REM sleep EEG in rats
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Aging does not affect the sleep endocrine response to total sleep deprivation in humans
Murck, H., Antonijevic, I. A., Schier, T., Frieboes, R.-M., Barthelmes, J., & Steiger, A. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00048-2 · Cited by 23 · see citing works
γ-Aminobutyric AcidA (GABAA) Agonist 4,5,6,7-Tetrahydroisoxazolo[4,5-c]pyridin-3-ol Persistently Increases Sleep Maintenance and Intensity during Chronic Administration to Rats
Lancel, M., & Langebartels, A. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39335-8 · Cited by 23 · see citing works
Hyporesponsiveness of the Pituitary to CRH during Slow Wave Sleep Is Not Mimicked by Systemic GHRH
Antonijevic, I. A., Murck, H., Frieboes, R.-M., Holsboer, F., & Steiger, A. (1999) · Neuroendocrinology · doi:10.1159/000054406 · Cited by 22 · see citing works
Sleep-associated variations in plasma renin activity and blood pressure in the rat
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Revisiting the Ehlers and Kupfer hypothesis: The growth hormone cortisol secretion ratio during sleep is correlated with electroencephalographic slow wave activity in normal volunteers
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Minireview: Gender-specific sleep regulation*
Kimura, M. (2005) · Sleep and Biological Rhythms · doi:10.1111/j.1479-8425.2005.00168.x · Cited by 15 · see citing works
Longtime Administration of Growth Hormone-Releasing Hormone (GHRH) does not Restore the Reduced Efficiency of GHRH on Sleep Endocrine Activity in 2 Old-Aged Subjects - a Preliminary Study
Murck, H., Frieboes, R.-M., Schier, T., & Steiger, A. (1997) · Pharmacopsychiatry · doi:10.1055/s-2007-979496 · Cited by 11 · see citing works
Alpha-Helical CRH Exerts CRH Agonistic Effects on Sleep-Endocrine Activity in Humans
Held, K., Antonijevic, I. A., Murck, H., Kunzel, H. E., & Steiger, A. (2005) · Neuropsychobiology · doi:10.1159/000086606 · Cited by 9 · see citing works
Cortisol promotes non-REM sleep in patients with major depression
Schmid, D. A., Brünner, H., Holsboer, F., & Frieß, E. (2000) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(00)80224-2 · Cited by 6 · see citing works
Reply to the comment on ‘Melatonin as a hypnotic: Pro’
Zhdanova, I. V. (2004) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.09.003 · Cited by 5 · see citing works
CNS-specific overexpression of CRH alters sleep-wake behavior in transgenic mice
Müller-Preuss, P., Wiesner, E., Lu, A., Deussing, J., & Kimura, M. (2005) · Pharmacopsychiatry · doi:10.1055/s-2005-918788 · Cited by 3 · see citing works
Effects of progesterone on sleep and cognition in healthy postmenopausal women
SCHÜSSLER, P., Kluge, M., Dresler, M., Yassouridis, A., Held, K., Zihl, J., & Steiger, A. (2005) · Pharmacopsychiatry · doi:10.1055/s-2005-918841 · Cited by 2 · see citing works
Effects of sleep deprivation on ghrelin, ACTH, GH and cortisol secretion in normal controls
SCHÜSSLER, P., Uhr, M., Ising, M., Weikel, J., Schmid, D. A., Held, K., Mathias, S., & Steiger, A. (2005) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2005-862892 · Cited by 2 · see citing works
Effects of progesterone on sleep and cognition in healthy postmenopausal women
SCHÜSSLER, P., Kluge, M., Dresler, M., Yassouridis, A., Held, K., Zihl, J., & Steiger, A. (2005) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2005-920466 · Cited by 2 · see citing works
Effects of progesterone on sleep and cognition in healthy postmenopausal women
Kluge, M., SCHÜSSLER, P., Dresler, M., Yassouridis, A., Held, K., Zihl, J., & Steiger, A. (2006) · Max Planck Institute for Plasma Physics · Cited by 1 · see citing works

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REM sleep dysregulation in depression: state of the art
Palagini, L., Baglioni, C., Ciapparelli, A., Gemignani, A., & Riemann, D. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.11.001 · Cited by 513 · see citing works
Interactions between sleep, stress, and metabolism: From physiological to pathological conditions
Hirotsu, C., Tufik, S., & Andersen, M. L. (2015) · Sleep Science · doi:10.1016/j.slsci.2015.09.002 · Cited by 527 · see citing works
Stress Hormone Regulation: Biological Role and Translation into Therapy
Holsboer, F., & Ising, M. (2010) · Annual Review of Psychology · doi:10.1146/annurev.psych.093008.100321 · Cited by 473 · see citing works
The interaction between sleep quality and academic performance
Ahrberg, K., Dresler, M., Niedermaier, S., Steiger, A., & Genzel, L. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.09.008 · Cited by 371 · see citing works
Self-citation
Wake and sleep EEG provide biomarkers in depression
Steiger, A., & Kimura, M. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.08.013 · Cited by 302 · see citing works
Sleep and its importance in adolescence and in common adolescent somatic and psychiatric conditions
Brand, S., & Kirov, R. (2011) · International Journal of General Medicine · doi:10.2147/ijgm.s11557 · Cited by 296 · see citing works
Sleep homeostasis: a role for adenosine in humans?
Landolt, H.-P. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.02.024 · Cited by 290 · see citing works
Stress & sleep: A relationship lasting a lifetime
Martire, V. L., Caruso, D., Palagini, L., Zoccoli, G., & Bastianini, S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.08.024 · Cited by 296 · see citing works
Insomnia and depression
Benca, R. M., & Peterson, M. J. (2008) · Sleep Medicine · doi:10.1016/s1389-9457(08)70010-8 · Cited by 251 · see citing works
The role of REM sleep theta activity in emotional memory
Hutchison, I. C., & Rathore, S. (2015) · Frontiers in Psychology · doi:10.3389/fpsyg.2015.01439 · Cited by 245 · see citing works
Does inadequate sleep play a role in vulnerability to obesity?
Knutson, K. L. (2012) · American Journal of Human Biology · doi:10.1002/ajhb.22219 · Cited by 241 · see citing works
Sleep disturbance as a universal risk factor for relapse in addictions to psychoactive substances
Brower, K. J., & Perron, B. E. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2009.10.020 · Cited by 226 · see citing works
Reduced orexin levels in the cerebrospinal fluid of suicidal patients with major depressive disorder
Brundin, L., Björkqvist, M., Petersén, Å., & Träskman‐Bendz, L. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.01.005 · Cited by 213 · see citing works
A Meta-Analysis of Electroencephalographic Sleep in Depression: Evidence for Genetic Biomarkers
Pillai, V., Kalmbach, D. A., & Ciesla, J. A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.07.016 · Cited by 210 · see citing works
The Neurobiology of Sleep and Wakefulness
Schwartz, M. D., & Kilduff, T. S. (2015) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2015.07.002 · Cited by 207 · see citing works
Sleep and recovery from critical illness and injury: A review of theory, current practice, and future directions*
Friese, R. S. (2008) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181643f29 · Cited by 206 · see citing works
Increased objectively assessed vigorous-intensity exercise is associated with reduced stress, increased mental health and good objective and subjective sleep in young adults.
Gerber, M., Brand, S., Herrmann, C., Colledge, F., Holsboer-trachsler, E., & Pühse, U. (2014) · Physiology and Behavior · doi:10.1016/j.physbeh.2014.05.047 · Cited by 175 · see citing works
Influence of mindfulness practice on cortisol and sleep in long-term and short-term meditators
Brand, S., Holsboer-Trachsler, E., Naranjo, J. R., & Schmidt, S. (2012) · Neuropsychobiology · doi:10.1159/000330362 · Cited by 169 · see citing works
The GABAA receptor: a novel target for treatment of fragile X?
D’Hulst, C., & Kooy, R. F. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.003 · Cited by 166 · see citing works
The role of rapid eye movement sleep for amygdala-related memory processing
Genzel, L., Spoormaker, V. I., Konrad, B. N., & Dresler, M. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.01.008 · Cited by 161 · see citing works
HPA axis activity in patients with chronic insomnia: A systematic review and meta-analysis of case–control studies
Dressle, R. J., Feige, B., Spiegelhalder, K., Schmucker, C., Benz, F., Mey, N. C., & Riemann, D. (2022) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2022.101588 · Cited by 161 · see citing works
Stress, Arousal, and Sleep
Sanford, L. D., Suchecki, D., & Meerlo, P. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_314 · Cited by 155 · see citing works
Sleep in Mood Disorders
Peterson, M. J., & Benca, R. M. (2006) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2006.09.003 · Cited by 164 · see citing works
Allatostatin A Signalling in Drosophila Regulates Feeding and Sleep and Is Modulated by PDF
Chen, J., Reiher, W., Hermann-Luibl, C., Sellami, A., Cognigni, P., Kondo, S., Helfrich‐Förster, C., Veenstra, J. A., & Wegener, C. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1006346 · Cited by 153 · see citing works
Role of GABAAreceptors in the physiology and pharmacology of sleep
Winsky‐Sommerer, R. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06716.x · Cited by 144 · see citing works
Sleep Disturbances in Mood Disorders
Rumble, M. E., White, K. H., & Benca, R. M. (2015) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2015.07.006 · Cited by 143 · see citing works
Sleep and Antidepressant Treatment
Wichniak, A., Wierzbicka, A., & Jernajczyk, W. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212803523608 · Cited by 142 · see citing works
A Tilted Axis: Maladaptive Inflammation and HPA Axis Dysfunction Contribute to Consequences of TBI
Tapp, Z. M., Godbout, J. P., & Kokiko‐Cochran, O. N. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00345 · Cited by 130 · see citing works
Orexin neurons are indispensable for stress-induced thermogenesis in mice
Zhang, W., Sunanaga, J., Takahashi, Y., Mori, T., Sakurai, T., Kanmura, Y., & Kuwaki, T. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.195099 · Cited by 128 · see citing works
Hypothalamic-Pituitary-Adrenal Axis Function in Chronic Fatigue Syndrome
Eede, F. V. D., Moorkens, G. H., Houdenhove, B. V., Cosyns, P. R., & Claes, S. J. (2007) · Neuropsychobiology · doi:10.1159/000104468 · Cited by 124 · see citing works
The Hypothalamic-Pituitary-Adrenal Axis, Obesity, and Chronic Stress Exposure: Sleep and the HPA Axis in Obesity
Lucassen, E. A., & Cizza, G. (2012) · Current Obesity Reports · doi:10.1007/s13679-012-0028-5 · Cited by 122 · see citing works
Exercising, sleep-EEG patterns, and psychological functioning are related among adolescents
Brand, S., Gerber, M., Beck, J., Hatzinger, M., Pühse, U., & Holsboer-Trachsler, E. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622970903522501 · Cited by 120 · see citing works
Conditional corticotropin-releasing hormone overexpression in the mouse forebrain enhances rapid eye movement sleep
Kimura, M., Müller-Preuss, P., Lu, A., Wiesner, E., Flachskamm, C., Wurst, W., Holsboer, F., & Deussing, J. M. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.46 · Cited by 111 · see citing works
Emerging anti-insomnia drugs: tackling sleeplessness and the quality of wake time
Wafford, K. A., & Ebert, B. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2464 · Cited by 109 · see citing works
A Comparative Study of Sleep Quality Between Pregnant and Nonpregnant Taiwanese Women
Ko, S., Chang, S., & Chen, C. (2010) · Journal of Nursing Scholarship · doi:10.1111/j.1547-5069.2009.01326.x · Cited by 102 · see citing works
Sleep Disturbances and Fatigue in Critically Ill Patients
Matthews, E. E. (2011) · AACN Advanced Critical Care · doi:10.1097/nci.0b013e31822052cb · Cited by 102 · see citing works
Electroencephalographic sleep profiles and hypothalamic–pituitary–adrenocortical (HPA)-activity in kindergarten children: Early indication of poor sleep quality associated with increased cortisol secretion
Hatzinger, M., Brand, S., Perren, S., Stadelmann, S., von Wyl, A., von Klitzing, K., & Holsboer‐Trachsler, E. (2007) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2007.05.010 · Cited by 99 · see citing works
The Interplay of Stress and Sleep Impacts BDNF Level
Giese, M., Unternäehrer, E., Brand, S., Calabrese, P., Holsboer‐Trachsler, E., & Eckert, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076050 · Cited by 99 · see citing works
Sympathetic activity and hypothalamo-pituitary-adrenal axis activity during sleep in post-traumatic stress disorder: a study assessing polysomnography with simultaneous blood sampling
van Liempt, S., Arends, J., Cluitmans, P. J. M., Westenberg, H. G. M., Kahn, R. S., & Vermetten, E. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.05.015 · Cited by 102 · see citing works
Risk Markers for Depression in Adolescents: Sleep and HPA Measures
Rao, U., Hammen, C. L., & Poland, R. E. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.27 · Cited by 96 · see citing works
Sleep disturbances and PTSD: a perpetual circle?
van Liempt, S. (2012) · European Journal of Psychotraumatology · doi:10.3402/ejpt.v3i0.19142 · Cited by 93 · see citing works
Non-Pharmacological Treatment of Insomnia
Siebern, A. T., Suh, S., & Nowakowski, S. (2012) · Neurotherapeutics · doi:10.1007/s13311-012-0142-9 · Cited by 88 · see citing works
Multilevel Interactions of Stress and Circadian System: Implications for Traumatic Stress
Agorastos, A., Nicolaides, N. C., Bozikas, V. P., Chrousos, G. P., & Pervanidou, P. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.01003 · Cited by 89 · see citing works
How stressful are 105days of isolation? Sleep EEG patterns and tonic cortisol in healthy volunteers simulating manned flight to Mars
Gemignani, A., Piarulli, A., Menicucci, D., Laurino, M., Rota, G., Mastorci, F., Gushin, V., Shevchenko, O., Garbella, E., Pingitore, A., et al. (2014) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2014.04.008 · Cited by 84 · see citing works
Alterations in Hypothalamus-Pituitary-Adrenal/Thyroid Axes and Gonadotropin-Releasing Hormone in the Patients With Primary Insomnia: A Clinical Research
Xia, L., Chen, G.-H., Li, Z.-H., Jiang, S., & Shen, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071065 · Cited by 83 · see citing works
Neuropeptidergic control of sleep and wakefulness
Richter, C., Woods, I. G., & Schier, A. F. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-062111-150447 · Cited by 75 · see citing works
Rhythmicity in mice selected for extremes in stress reactivity: behavioural, endocrine and sleep changes resembling endophenotypes of major depression
Touma, C., Fenzl, T., Ruschel, J., Palme, R., Holsboer, F., Kimura, M., & Landgraf, R. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004325 · Cited by 77 · see citing works
Spindle Oscillations in Sleep Disorders: A Systematic Review
Weiner, O. M., & Dang‐Vu, T. T. (2016) · Neural Plasticity · doi:10.1155/2016/7328725 · Cited by 74 · see citing works
Ghrelin and its interactions with growth hormone, leptin and orexins: Implications for the sleep–wake cycle and metabolism
García‐García, F., Juárez‐Aguilar, E., Santiago-Garcı́a, J., & Cardinali, D. P. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2013.04.003 · Cited by 71 · see citing works
Sleep dysfunction prior to the onset of schizophrenia: A review and neurodevelopmental diathesis–stress conceptualization.
Lunsford‐Avery, J. R., & Mittal, V. A. (2013) · Clinical Psychology Science and Practice · doi:10.1111/cpsp.12041 · Cited by 73 · see citing works
Possible nitric oxide modulation in protective effect of (Curcuma longa, Zingiberaceae) against sleep deprivation-induced behavioral alterations and oxidative damage in mice
Kumar, A., & Singh, A. (2008) · Phytomedicine · doi:10.1016/j.phymed.2008.02.003 · Cited by 71 · see citing works
Ghrelin in mental health, sleep, memory
Steiger, A., Dresler, M., SCHÜSSLER, P., & Kluge, M. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.02.013 · Cited by 70 · see citing works
Gender differences in the associations between types of childhood maltreatment and sleep disturbance among Chinese adolescents
Xiao, D., Wang, T., Huang, Y., Wang, W., Zhao, M., Zhang, W., Guo, L., & Lu, C. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.11.099 · Cited by 70 · see citing works
Sleep actigraphy pattern and behavioral/emotional difficulties in kindergarten children: Association with hypothalamic-pituitary-adrenocortical (HPA) activity
Hatzinger, M., Brand, S., Perren, S., Stadelmann, S., von Wyl, A., von Klitzing, K., & Holsboer‐Trachsler, E. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.08.012 · Cited by 68 · see citing works
Neuroscience-driven discovery and development of sleep therapeutics
Dresler, M., Spoormaker, V. I., Beitinger, P., Czisch, M., Kimura, M., Steiger, A., & Holsboer, F. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.10.012 · Cited by 63 · see citing works
Evidence of favorable sleep-EEG patterns in adolescent male vigorous football players compared to controls
Brand, S., Beck, J., Gerber, M., Hatzinger, M., & Holsboer‐Trachsler, E. (2010) · The World Journal of Biological Psychiatry · doi:10.3109/15622970903079820 · Cited by 64 · see citing works
Pathology of Sleep, Hormones and Depression
Steiger, A., Dresler, M., Kluge, M., & SCHÜSSLER, P. (2013) · Pharmacopsychiatry · doi:10.1055/s-0033-1337921 · Cited by 61 · see citing works
Impaired off-line memory consolidation in depression.
Dresler, M., Kluge, M., Genzel, L., Schüssler, P., & Steiger, A. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.02.002 · Cited by 64 · see citing works
Evidence of favorable sleep-EEG patterns in adolescent male vigorous football players compared to controls
Brand, S., Beck, J., Gerber, M., Hatzinger, M., & Holsboer‐Trachsler, E. (2009) · The World Journal of Biological Psychiatry · doi:10.1080/15622970903079820 · Cited by 77 · see citing works
Ghrelin alone or co-administered with GHRH or CRH increases non-REM sleep and decreases REM sleep in young males
Kluge, M., SCHÜSSLER, P., Bleninger, P., Kleyer, S., Uhr, M., Weikel, J. C., Yassouridis, A., Zuber, V., & Steiger, A. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.01.008 · Cited by 56 · see citing works
Decreased nocturnal growth hormone secretion and sleep fragmentation in combat-related posttraumatic stress disorder; potential predictors of impaired memory consolidation
van Liempt, S., Vermetten, E. H. G. J. M., Lentjes, E. G. W. M., Arends, J. B. A. M., & Westenberg, H. G. M. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.03.009 · Cited by 57 · see citing works
Such stuff as dreams are made on? Elaborative encoding, the ancient art of memory, and the hippocampus
Llewellyn, S. (2013) · Behavioral and Brain Sciences · doi:10.1017/s0140525x12003135 · Cited by 95 · see citing works
The stress hormone system in various sleep disorders
Lattova, Z., Keckeis, M., Maurovich-Horvat, E., Wetter, T. C., Wilde-Frenz, J., Schuld, A., & Pollmächer, T. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.03.013 · Cited by 54 · see citing works
The efficacy of pregabalin and benzodiazepines in generalized anxiety disorder presenting with high levels of insomnia
Montgomery, S., Herman, B. K., Schweizer, E. E., & Mandel, F. S. (2009) · International Clinical Psychopharmacology · doi:10.1097/yic.0b013e32832dceb9 · Cited by 53 · see citing works
Effect of oxidative stress induced by paradoxical sleep deprivation on the activities of Na+, K+-ATPase and acetylcholinesterase in the cortex and hippocampus of rat
Khadrawy, Y. A., Nour, N. A., & Ezz, H. S. A. (2010) · Translational research · doi:10.1016/j.trsl.2010.11.005 · Cited by 53 · see citing works
Sleep Quality of Hospitalized Patients in Surgical Units*
Yılmaz, M., Sayın, Y., & Gürler, H. (2012) · Nursing Forum · doi:10.1111/j.1744-6198.2012.00268.x · Cited by 52 · see citing works
Poor sleep is associated with exaggerated cortisol response to the combined dexamethasone/CRH test in a non-clinical population
Hori, H., Teraishi, T., Sasayama, D., Ozeki, Y., Matsuo, J., Kawamoto, Y., Kinoshita, Y., Hattori, K., Higuchi, T., & Kunugi, H. (2011) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2011.04.001 · Cited by 52 · see citing works
Sleep disturbances in highly stress reactive mice: Modeling endophenotypes of major depression
Fenzl, T., Touma, C., Romanowski, C. P. N., Ruschel, J., Holsboer, F., Landgraf, R., Kimura, M., & Yassouridis, A. (2011) · BMC Neuroscience · doi:10.1186/1471-2202-12-29 · Cited by 52 · see citing works
Traumatic stress and the circadian system: neurobiology, timing and treatment of posttraumatic chronodisruption
Agorastos, A., & Olff, M. (2020) · European Journal of Psychotraumatology · doi:10.1080/20008198.2020.1833644 · Cited by 53 · see citing works
Maternal dexamethasone and EEG hyperactivity in preterm fetal sheep
Davidson, J. O., Quaedackers, J. S. L. T., George, S. A., Gunn, A. J., & Bennet, L. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.212043 · Cited by 51 · see citing works
Bi-Directional Associations Between Psychological Arousal, Cortisol, and Sleep
Garde, A. H., Albertsen, K., Persson, R., Hansen, Å. M., & Rugulies, R. (2012) · Behavioral Sleep Medicine · doi:10.1080/15402002.2012.636272 · Cited by 51 · see citing works
Polymorphisms in the galanin gene are associated with symptom–severity in female patients suffering from panic disorder
Unschuld, P. G., Ising, M., Erhardt, A., Lucae, S., Kohli, M., Kloiber, S. M., Salyakina, D., Thoeringer, C. K., Kern, N., Lieb, R., et al. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2007.05.006 · Cited by 48 · see citing works
Lipids shape brain function through ion channel and receptor modulations: physiological mechanisms and clinical perspectives
Incontro, S., Musella, M. L., Sammari, M., Scala, C. D., Fantini, J., & Debanne, D. (2024) · Physiological Reviews · doi:10.1152/physrev.00004.2024 · Cited by 48 · see citing works
Sleep in Mood Disorders
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Authors: Steiger, A.
Affiliations: Max Planck Institute of Psychiatry (DE)
Corresponding author: Steiger, Axel
ORCID: Steiger, Axel
Venue: Journal of Psychiatric Research
Publisher: Elsevier BV
Published: 2007-10
Volume: 41
Issue: 7
Pages: 537-552
ISSN: 0022-3956 (ISSN-L)
DOI: 10.1016/j.jpsychires.2006.04.007
OpenAlex: W2060446870
Cited by: 262
References: 188
Citations by year: 2026: 4 · 2025: 15 · 2024: 10 · 2023: 8 · 2022: 5 · 2021: 19 · 2020: 10 · 2019: 9 · 2018: 9 · 2017: 5 · 2016: 7 · 2015: 11 · 2014: 14 · 2013: 18 · 2012: 20
FWCI: 7.77
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Psychiatric Research (publishedVersion)
PubMed (publishedVersion)
Max Planck Institute for Plasma Physics (submittedVersion)
Funders: Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: sleep regulation, neuropeptides, growth hormone-releasing hormone, corticotropin-releasing factor, somatostatin, ghrelin, galanin, neuropeptide Y, vasoactive intestinal peptide, neurosteroids, cortisol, estrogen, menopause, GABA-A receptor agonists, gaboxadol, tiagabine, benzodiazepines, REM sleep, slow-wave sleep, depression, aging
MeSH terms: Tiagabine, Brain, Corticotropin-Releasing Hormone, Electroencephalography, Estrogens, Humans, Hypnotics and Sedatives, Hypothalamo-Hypophyseal System, Sleep Initiation and Maintenance Disorders, Isoxazoles, Neuropeptides, Nipecotic Acids, Pituitary-Adrenal System, Sleep Stages, Growth Hormone-Releasing Hormone, GABA Agonists, Hormone Replacement Therapy, GABA-A Receptor Agonists

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Neurochemical regulation of sleep

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