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Cited by 482

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Diabetes, Alzheimer disease, and vascular dementia: A population-based neuropathologic study

Ahtiluoto, S., Polvikoski, T., Peltonen, M., Solomon, A., Tuomilehto, J., Winblad, B., Sulkava, R., Kivipelto, M.·2010·Neurology
DOI 10.1212/wnl.0b013e3181f4d7f8
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Abstract

Objective: To investigate the relation of diabetes to dementia, Alzheimer disease (AD), and vascular dementia (VaD), through analyses of incidence, mortality, and neuropathologic outcomes in a prospective population-based study of the oldest old. Methods: The Vantaa 85+ study included 553 residents living in the city of Vantaa, Finland, and aged ≥85 years on April 1, 1991. Survivors were reexamined in 1994, 1996, 1999, and 2001. Autopsies were performed in 291 persons who died during the follow-up (48% of total population). Diabetes was assessed according to self-report, medical record of physician-diagnosed diabetes, or use of antidiabetic medication. Macroscopic infarcts were identified from 1-cm coronal slices of cerebral hemispheres, 5-mm transverse brainstem slices, and sagittal cerebellum slices. Methenamine silver staining was used for β-amyloid, methenamine silver-Bodian staining for neurofibrillary tangles, and modified Bielschowsky method for neuritic plaques. Cox proportional hazards and multiple logistic regression models were used to analyze the association of diabetes with dementia and neuropathology, respectively. Results: Diabetes at baseline doubled the incidence of dementia, AD, and VaD, and increased mortality. Individuals with diabetes were less likely to have β-amyloid (hazard ratio [HR] [95% confidence interval (CI)] was 0.48 [0.23–0.98]) and tangles (HR [95% CI] 0.72 [0.39–1.33]) but more likely to have cerebral infarcts (HR [95% CI] 1.88 [1.06–3.34]) after all adjustments. Conclusion: Elderly patients with diabetes develop more extensive vascular pathology, which alone or together with AD-type pathology (particularly in APOE ε4 carriers) results in increased dementia risk.

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Cites

Show all 10 references

Research works printed but not linked: 23

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  3. Hayden KM, Zandi PP, Lyketsos CG, et al. Vascular risk factors for incident Alzheimer disease and vascular dementia: the Cache County study. Alzheimer Dis Assoc Disord 2006;20:93–100.
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  5. 10.1017/S104161020200844X · DOI
  6. Tuomilehto J Rastenyte D Qiao Q Jakovljevic D. Epidemiology of macrovascular disease and hypertension in diabetes mellitus. In: International Textbook of Diabetes Mellitus Third Edition. Milan: John Wiley & Sons; 2004:1345–1370. · DOI
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  14. 10.1111/j.1365-2990.1989.tb01252.x · DOI
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Cited by

Metadata

Authors
Ahtiluoto, S., Polvikoski, T., Peltonen, M., Solomon, A., Tuomilehto, J., Winblad, B., Sulkava, R., & Kivipelto, M.
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2010-09-28
Volume
75
Issue
13
Pages
1195-1202
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.0b013e3181f4d7f8
OpenAlex
W2146343703
Cited by
482
References
10
FWCI
14.16
Type
journal article
Language
en
Open access
closed

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