Controlled trial of N-acetylcysteine for patients with probable Alzheimer’s disease
Abstract
The antioxidant N-acetylcysteine (NAC) or placebo was administered in a double-blind fashion to patients who met National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria for probable AD. Testing for efficacy occurred after 3 and 6 months of treatment. Comparison of interval change favored NAC treatment on nearly every outcome measure, although significant differences were obtained only for a subset of cognitive tasks.
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N-acetylcysteine augmentation of standard treatment in Alzheimer's disease was associated with improvements in verbal abilities and executive control cognitive tasks compared with controls.
“NAC augmentation of standard treatment in Alzheimer’s disease was associated with improvements in verbal abilities and executive control cognitive tasks compared with controls [157].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [157]
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Bobb, A. J., Arfsten, D. P., & Jederberg, W. W. (2005) · Military Medicine · doi:10.7205/milmed.170.1.52 · Cited by 39 · see citing works
Askari, M., Faryabi, R., Mozaffari, H., & Mofrad, M. D. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155239 · Cited by 38 · see citing works
Catumbela, C. S. G., Giridharan, V. V., Barichello, T., & Morales, R. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00369-7 · Cited by 37 · see citing works
N-Acetyl-l-Cysteine Protects Astrocytes against Proteotoxicity without Recourse to Glutathione
Gleixner, A. M., Hutchison, D. F., Sannino, S., Bhatia, T. N., Leak, L. C., Flaherty, P. T., Wipf, P., Brodsky, J. L., & Leak, R. K. (2017) · Molecular Pharmacology · doi:10.1124/mol.117.109926 · Cited by 36 · see citing works
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Do glutathione and copper interact to modify Alzheimer's disease pathogenesis?
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- Authors
- Adair, J. C., Knoefel, J. E., & Morgan, N.
- Affiliations
- University of New Mexico (US)
- Venue
- Neurology
- Published
- 2001-10-23
- Volume
- 57
- Issue
- 8
- Pages
- 1515-1517
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2084485820
- Cited by
- 240
- References
- 10
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 10 · 2023: 11 · 2022: 12 · 2021: 11 · 2020: 15 · 2019: 12 · 2018: 11 · 2017: 13 · 2016: 17 · 2015: 13 · 2014: 11 · 2013: 15 · 2012: 10
- FWCI
- 3.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Keywords
- N-acetylcysteine, Alzheimer's disease, antioxidants, cognitive function, NIA-AA criteria, treatment efficacy
- MeSH terms
- Acetylcysteine, Alzheimer Disease, Double-Blind Method, Female, Humans, Male, Free Radical Scavengers, Treatment Outcome
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