Cited by 240Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeurological Disorders and Treatments

Controlled trial of N-acetylcysteine for patients with probable Alzheimer’s disease

Adair, John C., Knoefel, Janice E., Morgan, Nancy·2001·Neurology

Abstract

The antioxidant N-acetylcysteine (NAC) or placebo was administered in a double-blind fashion to patients who met National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria for probable AD. Testing for efficacy occurred after 3 and 6 months of treatment. Comparison of interval change favored NAC treatment on nearly every outcome measure, although significant differences were obtained only for a subset of cognitive tasks.

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Crossref · 10.1212/wnl.57.8.1515

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10 of 10 references verified0 citation errors · 0 not checkable

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  • N-acetylcysteine augmentation of standard treatment in Alzheimer's disease was associated with improvements in verbal abilities and executive control cognitive tasks compared with controls.

    “NAC augmentation of standard treatment in Alzheimer’s disease was associated with improvements in verbal abilities and executive control cognitive tasks compared with controls [157].”

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Authors
Adair, J. C., Knoefel, J. E., & Morgan, N.
Affiliations
University of New Mexico (US)
Venue
Neurology
Published
2001-10-23
Volume
57
Issue
8
Pages
1515-1517
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
OpenAlex
W2084485820
Cited by
240
References
10
Citations by year
2026: 9 · 2025: 7 · 2024: 10 · 2023: 11 · 2022: 12 · 2021: 11 · 2020: 15 · 2019: 12 · 2018: 11 · 2017: 13 · 2016: 17 · 2015: 13 · 2014: 11 · 2013: 15 · 2012: 10
FWCI
3.19
Type
journal article
Language
en
Open access
closed
Locations
  • Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
Keywords
N-acetylcysteine, Alzheimer's disease, antioxidants, cognitive function, NIA-AA criteria, treatment efficacy
MeSH terms
Acetylcysteine, Alzheimer Disease, Double-Blind Method, Female, Humans, Male, Free Radical Scavengers, Treatment Outcome

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