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Biogenesis and germline functions of piRNAs

Klattenhoff, Carla, Theurkauf, William·2008·Development

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Abstract

Small interfering RNAs and microRNAs are generated from double-stranded RNA precursors by the Dicer endonucleases, and function with Argonaute-family proteins to target transcript destruction or to silence translation. A distinct class of 24- to 30-nucleotide-long RNAs, produced by a Dicer-independent mechanism, associates with Piwi-class Argonaute proteins. Studies in flies, fish and mice implicate these Piwi-associated RNAs (piRNAs)in germline development, silencing of selfish DNA elements, and in maintaining germline DNA integrity. However, whether piRNAs primarily control chromatin organization, gene transcription, RNA stability or RNA translation is not well understood, neither is piRNA biogenesis. Here, we review recent studies of piRNA production and function, and discuss unanswered questions about this intriguing new class of small RNAs.

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See all 517

Authors: Klattenhoff, C., & Theurkauf, W.
Venue: Development
Publisher: The Company of Biologists
Published: 2008-01-01
Volume: 135
Issue: 1
Pages: 3-9
ISSN: 0950-1991 (ISSN-L)
1477-9129
DOI: 10.1242/dev.006486
OpenAlex: W2125489084
Cited by: 517
References: 82
FWCI: 56.98
Type: journal article
Language: en
Open access: closed

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Biogenesis and germline functions of piRNAs

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