Metastasis-associated kinase modulates Wnt signaling to regulate brain patterning and morphogenesis
Open accessAbstract
Wnt signaling is a major pathway regulating cell fate determination, cell proliferation and cell movements in vertebrate embryos. Distinct branches of this pathway activate β-catenin/TCF target genes and modulate morphogenetic movements in embryonic tissues by reorganizing the cytoskeleton. The selection of different molecular targets in the pathway is driven by multiple phosphorylation events. Here, we report that metastasis-associated kinase (MAK) is a novel regulator of Wnt signaling during morphogenetic movements, and eye and brain development in Xenopus embryos. Injected MAK RNA suppressed Wnt transcriptional reporters and activated Jun N-terminal kinase. Furthermore, MAK was recruited to the cell membrane by Frizzled 3,formed a complex with Dishevelled and phosphorylated Dsh in vitro. The regional brain markers Otx2, En2 and Gbx2 were affected in embryos with modulated MAK activity in a manner consistent with a role for MAK in midbrain-hindbrain boundary formation. Confirming the inhibitory role for this kinase in Wnt/β-catenin signaling, the midbrain patterning defects in embryos depleted of MAK were rescued by the simultaneous depletion ofβ-catenin. These findings indicate that MAK may function in different developmental processes as a switch between the canonical and non-canonical branches of Wnt signaling.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dsh is phosphorylated by a number of kinases including Casein Kinase 1, Casein Kinase 2, Metastasis Associated Kinase, Protein Kinase C and Par1.
“Dsh is phosphorylated by a number of kinases including Casein Kinase 1,37 Casein Kinase 2,38 Metastasis Associated Kinase,39 Protein Kinase C40 and Par1.41”
From Wnt signal transduction pathways (2008) · cites this paper as [39]
Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589 · see citing works
The Wnt Signaling Pathway in Development and Disease
Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325 · see citing works
Appendix G: In Situ Hybridization: An Improved Whole-Mount Method for Xenopus Embryos
Harland, R. M. (1991) · Methods in cell biology · doi:10.1016/s0091-679x(08)60307-6 · Cited by 2,048 · see citing works
Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
Glinka, A., Wu, W., Delius, H., Monaghan, A. P., Blumenstock, C., & Niehrs, C. (1998) · Nature · doi:10.1038/34848 · Cited by 1,608 · see citing works
Normal Table of Xenopus Laevis (Daudin)
Gerhart, J. C., & Kirschner, M. W. (2020) · Garland Science eBooks · doi:10.1201/9781003064565 · Cited by 1,578 · see citing works
The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain
McMahon, A. P., & Bradley, A. (1990) · Cell · doi:10.1016/0092-8674(90)90385-r · Cited by 1,540 · see citing works
THE AMP-ACTIVATED/SNF1 PROTEIN KINASE SUBFAMILY: Metabolic Sensors of the Eukaryotic Cell?
Hardie, D. G., Carling, D., & Carlson, M. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.821 · Cited by 1,436 · see citing works
Veeman, M. T., Axelrod, J. D., & Moon, R. T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00266-1 · Cited by 1,359 · see citing works
Expression of achaete-scute homolog 3 in Xenopus embryos converts ectodermal cells to a neural fate.Preprint
Turner, D. L., & Weintraub, H. (1994) · Genes & Development · doi:10.1101/gad.8.12.1434 · Cited by 1,023 · see citing works
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
Zeng, X., Tamai, K., Doble, B. W., Li, S., Huang, H., Habas, R., Okamura, H., Woodgett, J. R., & He, X. (2005) · Nature · doi:10.1038/nature04185 · Cited by 849 · see citing works
Habas, R., Kato, Y., & He, X. (2001) · Cell · doi:10.1016/s0092-8674(01)00614-6 · Cited by 842 · see citing works
FORMATION AND FUNCTION OF SPEMANN'S ORGANIZER
Harland, R., & Gerhart, J. (1997) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.13.1.611 · Cited by 839 · see citing works
Boutros, M., Paricio, N., Strutt, D. I., & Mlodzik, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81226-x · Cited by 801 · see citing works
Slusarski, D. C., Corces, V. G., & Moon, R. T. (1997) · Nature · doi:10.1038/37138 · Cited by 680 · see citing works
Tada, M., & Smith, J. C. (2000) · Development · doi:10.1242/dev.127.10.2227 · Cited by 675 · see citing works
Axelrod, J. D., Miller, J. R., Shulman, J. M., Moon, R. T., & Perrimon, N. (1998) · Genes & Development · doi:10.1101/gad.12.16.2610 · Cited by 659 · see citing works
WNTS in the vertebrate nervous system: from patterning to neuronal connectivity
Ciani, L., & Salinas, P. C. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1665 · Cited by 631 · see citing works
Wallingford, J. B., Fraser, S. E., & Harland, R. M. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00197-1 · Cited by 613 · see citing works
Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation
Habas, R., Dawid, I. B., & He, X. (2003) · Genes & Development · doi:10.1101/gad.1022203 · Cited by 603 · see citing works
Neural plate patterning: Upstream and downstream of the isthmic organizer
Wurst, W., & Bally‐Cuif, L. (2001) · Nature reviews. Neuroscience · doi:10.1038/35053516 · Cited by 574 · see citing works
Winter, C. G., Wang, B., Ballew, A. C., Royou, A., Karess, R. E., Axelrod, J. D., & Luo, L. (2001) · Cell · doi:10.1016/s0092-8674(01)00298-7 · Cited by 555 · see citing works
Tao, Q., Yokota, C., Puck, H., Kofron, M., Birsoy, B., Yan, D., Asashima, M., Wylie, C. C., Lin, X., & Heasman, J. (2005) · Cell · doi:10.1016/j.cell.2005.01.013 · Cited by 510 · see citing works
The developmental biology of Dishevelled: an enigmatic protein governing cell fate and cell polarity
Wallingford, J. B., & Habas, R. (2005) · Development · doi:10.1242/dev.02068 · Cited by 509 · see citing works
Injected Wnt RNA induces a complete body axis in Xenopus embryos
Sokol, S. Y., Christian, J. L., Moon, R. T., & Melton, D. A. (1991) · Cell · doi:10.1016/0092-8674(91)90069-b · Cited by 501 · see citing works
Self-citationA frizzled homolog functions in a vertebrate Wnt signaling pathway
Yang-Snyder, J., Miller, J. R., Brown, J. D., Lai, C.-J., & Moon, R. T. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70716-1 · Cited by 469 · see citing works
Hamblet, N. S., Lijam, N., Ruiz‐Lozano, P., Wang, J., Yang, Y., Luo, Z., Mei, L., Chien, K. R., Sussman, D. J., & Wynshaw-Boris, A. J. (2002) · Development · doi:10.1242/dev.00164 · Cited by 438 · see citing works
Pannese, M., Polo, C., Andreazzoli, M., Vignali, R., Kablar, B., Barsacchi, G., & Boncinelli, E. (1995) · Development · doi:10.1242/dev.121.3.707 · Cited by 428 · see citing works
Analysis of Dishevelled signalling pathways during Xenopus development
Sokol, S. Y. (1996) · Current Biology · doi:10.1016/s0960-9822(96)00750-6 · Cited by 406 · see citing works
Self-citationThe dishevelled protein is modified by wingless signaling in Drosophila.Preprint
Yanagawa, S.-I., van Leeuwen, F. N., Wodarz, A., Klingensmith, J., & Nusse, R. (1995) · Genes & Development · doi:10.1101/gad.9.9.1087 · Cited by 388 · see citing works
The planar cell-polarity gene stbm regulates cell behaviour and cell fate in vertebrate embryos
Park, M., & Moon, R. T. (2002) · Nature Cell Biology · doi:10.1038/ncb716 · Cited by 381 · see citing works
A role for Gbx2 in repression of Otx2 and positioning the mid/hindbrain organizer
Millet, S., Campbell, K., Epstein, D. J., Losos, K., Harris, E., & Joyner, A. L. (1999) · Nature · doi:10.1038/43664 · Cited by 359 · see citing works
Dishevelled activates Ca2+ flux, PKC, and CamKII in vertebrate embryos
Sheldahl, L. C., Slusarski, D. C., Pandur, P., Miller, J. R., Kühl, M., & Moon, R. T. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211094 · Cited by 350 · see citing works
Chi, C. L., Martı́nez, S., Wurst, W., & Martin, G. R. (2003) · Development · doi:10.1242/dev.00487 · Cited by 343 · see citing works
Marlow, F., Topczewski, J., Sepich, D., & Solnica-Krezel, L. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00864-3 · Cited by 337 · see citing works
Joyner, A. L., & Martin, G. R. (1987) · Genes & Development · doi:10.1101/gad.1.1.29 · Cited by 328 · see citing works
The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos
Saneyoshi, T., Kume, S., Amasaki, Y., & Mikoshiba, K. (2002) · Nature · doi:10.1038/417295a · Cited by 322 · see citing works
Blitz, I. L., & Cho, W. Y. (1995) · Development · doi:10.1242/dev.121.4.993 · Cited by 314 · see citing works
Rothbächer, U., Laurent, M. N., Deardorff, M. A., Klein, P. S., Cho, K. W. Y., & Fraser, S. E. (2000) · The EMBO Journal · doi:10.1093/emboj/19.5.1010 · Cited by 299 · see citing works
Shulman, J. M., Benton, R., & Johnston, D. S. (2000) · Cell · doi:10.1016/s0092-8674(00)80848-x · Cited by 282 · see citing works
Frizzled-7 signalling controls tissue separation during Xenopus gastrulation
Winklbauer, R., Medina, A., Swain, R. K., & Steinbeisser, H. (2001) · Nature · doi:10.1038/35101621 · Cited by 263 · see citing works
Brivanlou, A. H., & Harland, R. M. (1989) · Development · doi:10.1242/dev.106.3.611 · Cited by 256 · see citing works
PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling
Sun, T., Lu, B., Feng, J., Reinhard, C., Jan, Y. N., Fantl, W. J., & Williams, L. T. (2001) · Nature Cell Biology · doi:10.1038/35083016 · Cited by 255 · see citing works
Early Anterior/Posterior Patterning of the Midbrain and Cerebellum
Liu, A., & Joyner, A. L. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.869 · Cited by 248 · see citing works
Nuclear localization is required for Dishevelled function in Wnt/β-catenin signaling
Itoh, K., Brott, B. K., Bae, G.-U., Ratcliffe, M. J., & Sokol, S. Y. (2005) · Journal of Biology · doi:10.1186/jbiol20 · Cited by 221 · see citing works
Self-citationBradley, L., Snape, A. M., Bhatt, S., & Wilkinson, D. G. (1993) · Mechanisms of Development · doi:10.1016/0925-4773(93)90089-g · Cited by 212 · see citing works
Cavodeassi, F., Carreira-Barbosa, F., Young, R., Concha, M. L., Allende, M. L., Houart, C., Tada, M., & Wilson, S. W. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.026 · Cited by 207 · see citing works
The prickle-Related Gene in Vertebrates Is Essential for Gastrulation Cell Movements
Takeuchi, M., Nakabayashi, J., Sakaguchi, T. F., Yamamoto, T. S., Takahashi, H., Takeda, H., & Ueno, N. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00245-8 · Cited by 193 · see citing works
Sokol, S. Y., Klingensmith, J., Perrimon, N., & Itoh, K. (1995) · Development · doi:10.1242/dev.121.6.1637 · Cited by 189 · see citing works
Self-citationGastrulation movements provide an early marker of mesoderm induction in Xenopus laevis
Symes, K., & Smith, J. C. (1987) · Development · doi:10.1242/dev.101.2.339 · Cited by 175 · see citing works
Tomančák, P., Piano, F., Riechmann, V., Gunsalus, K. C., Kemphues, K. J., & Ephrussi, A. (2000) · Nature Cell Biology · doi:10.1038/35017101 · Cited by 168 · see citing works
Böhm, H., Brinkmann, V., Dráb, M., HENSKE, A., & Kurzchalia, T. V. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00260-0 · Cited by 165 · see citing works
Paraxial protocadherin coordinates cell polarity during convergent extension via Rho A and JNK
Unterseher, F., Hefele, J. A., Giehl, K., Robertis, E. M. D., Wedlich, D., & Schambony, A. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600332 · Cited by 153 · see citing works
Wnt signaling and dorso-ventral axis specification in vertebrates
Sokol, S. Y. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80061-6 · Cited by 146 · see citing works
Self-citationWnt–frizzled signaling in neural crest formation
Wu, J., Saint‐Jeannet, J., & Klein, P. S. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)00011-5 · Cited by 141 · see citing works
Physiological regulation of β-catenin stability by Tcf3 and CK1ϵ
Lee, E. N., Salic, A. N., & Kirschner, M. W. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200102074 · Cited by 141 · see citing works
Anterior-Posterior Polarity in C. elegans and Drosophila --PARallels and Differences
Pellettieri, J., & Seydoux, G. (2002) · Science · doi:10.1126/science.1072162 · Cited by 124 · see citing works
Ossipova, O., Dhawan, S., Sokol, S., & Green, J. B. A. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.04.011 · Cited by 113 · see citing works
Self-citationFrodo interacts with Dishevelled to transduce Wnt signals
Gloy, J., Hikasa, H., & Sokol, S. Y. (2002) · Nature Cell Biology · doi:10.1038/ncb784 · Cited by 113 · see citing works
Self-citationAn overview of the KIN1/PAR‐1/MARK kinase family
Tassan, J., & Goff, X. L. (2004) · Biology of the Cell · doi:10.1016/j.biolcel.2003.10.009 · Cited by 109 · see citing works
Interaction of Dishevelled and Xenopus Axin-Related Protein Is Required for Wnt Signal Transduction
Itoh, K., Antipova, A. A., Ratcliffe, M., & Sokol, S. Y. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.6.2228-2238.2000 · Cited by 95 · see citing works
Self-citationWnt signaling and transcriptional control of Siamois in Xenopus embryos
Fan, M. J., Grüning, W., Walz, G., & Sokol, S. Y. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.10.5626 · Cited by 91 · see citing works
Self-citationSokol, S. Y., Klingensmith, J., Perrrimon, N., & ltoh, K. (1995) · Development · doi:10.1242/dev.121.10.3487 · Cited by 86 · see citing works
Self-citationSpecification of the meso-isthmo-cerebellar region: The Otx2/Gbx2 boundary
Hidalgo‐Sánchez, M., Millet, S., Bloch‐Gallego, E., & Alvarado‐Mallart, R. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.01.010 · Cited by 85 · see citing works
A role for Wnts in morpho-genesis and tissue polarity
Sokol, S. Y. (2000) · Nature Cell Biology · doi:10.1038/35017136 · Cited by 84 · see citing works
Self-citationTheXenopus laevis homeo☐ geneXgbx-2 is an early marker of anteroposterior patterning in the ectoderm
von Bubnoff, A., Schmidt, J. E., & Kimelman, D. (1996) · Mechanisms of Development · doi:10.1016/0925-4773(95)00468-8 · Cited by 83 · see citing works
Two yeast genes that encode unusual protein kinases.
Levin, D. E., Hammond, C. I., Ralston, R., & Bishop, J. M. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.17.6035 · Cited by 81 · see citing works
Wu, J., Yang, J., & Klein, P. S. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2004.12.016 · Cited by 80 · see citing works
Molenaar, M., Roose, J. P., Peterson, J., Venanzi, S., Clevers, H. C., & Destrée, O. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00085-9 · Cited by 78 · see citing works
The involvement of Frodo in TCF-dependent signaling and neural tissue development
Hikasa, H., & Sokol, S. Y. (2004) · Development · doi:10.1242/dev.01369 · Cited by 73 · see citing works
Self-citationExpression of Xfz3, a Xenopus frizzled family member, is restricted to the early nervous system
Shi, D., Goisset, C., & Boucaut, J. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00166-4 · Cited by 66 · see citing works
Frizzled Receptors Activate a Novel JNK-Dependent Pathway that May Lead to Apoptosis
Lisovsky, M., Itoh, K., & Sokol, S. Y. (2002) · Current Biology · doi:10.1016/s0960-9822(01)00628-5 · Cited by 66 · see citing works
Self-citationClosing the gaps among a web of DNA repair disorders
Michelson, R. J., & Weinert, T. A. (2000) · BioEssays · doi:10.1002/1521-1878(200011)22:11 · Cited by 61 · see citing works
Itoh, K., & Sokol, S. Y. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(96)00627-2 · Cited by 59 · see citing works
Self-citationIdentification of novel protein kinases expressed in the myocardium of the developing mouse heart
Ruiz, J. C., Conlon, F. L., & Robertson, E. J. (1994) · Mechanisms of Development · doi:10.1016/0925-4773(94)90056-6 · Cited by 55 · see citing works
Autoregulation of canonical Wnt signaling controls midbrain development
Kunz, M., Herrmann, M., Wedlich, D., & Gradl, D. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.06.015 · Cited by 53 · see citing works
Neural induction takes a transcriptional twist
Bainter, J. J., Boos, A., & Kroll, K. L. (2001) · Developmental Dynamics · doi:10.1002/dvdy.1210 · Cited by 52 · see citing works
Drewes, G., & Nurse, P. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)01080-9 · Cited by 47 · see citing works
Two Frodo/Dapper homologs are expressed in the developing brain and mesoderm of zebrafish
Gillhouse, M., Nyholm, M. K., Hikasa, H., Sokol, S. Y., & Grinblat, Y. (2004) · Developmental Dynamics · doi:10.1002/dvdy.20060 · Cited by 41 · see citing works
Self-citationHedgepeth, C. M., Deardorff, M. A., & Klein, P. S. (1999) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00203-2 · Cited by 39 · see citing works
Developmental role of the SNF1-related kinase Hunk in pregnancy-induced changes in the mammary gland
Gardner, H. P., Belka, G. K., Wertheim, G. B. W., Hartman, J. L., Ha, S. I., Gimotty, P. A., Marquis, S. T., & Chodosh, L. A. (2000) · Development · doi:10.1242/dev.127.20.4493 · Cited by 35 · see citing works
Cloning and Characterization of Hunk, a Novel Mammalian SNF1-Related Protein Kinase
Gardner, H. P., Wertheim, G. B. W., Ha, S. I., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Marquis, S. T., & Chodosh, L. A. (2000) · Genomics · doi:10.1006/geno.1999.6078 · Cited by 35 · see citing works
Cell polarity pathways converge and extend to regulate neural tube closure
Zohn, I. E. (2003) · Trends in Cell Biology · doi:10.1016/s0962-8924(03)00173-9 · Cited by 29 · see citing works
Markers of vertebrate mesoderm induction
Stennard, F. A., Ryan, K., & Gurdon, J. B. (1997) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(97)80009-3 · Cited by 27 · see citing works
Hemochromatosis: a genetic defect in iron metabolism
Jazwinska, E. C. (1998) · BioEssays · doi:10.1002/(sici)1521-1878(199807)20:7 · Cited by 15 · see citing works
Korobko, Kabishev, A. A., & Киселев, С. Л. (1997) · PubMed · Cited by 14 · see citing works
Becker, J., & Brendel, M. (1996) · Current Microbiology · doi:10.1007/s002849900042 · Cited by 13 · see citing works
Pannese, M., Polo, C., Andreazzoli, M., Vignali, R., Kablar, B., Barsacchi, G., & Boncinelli, E. (1995) · HighWire Press Open Archive · Cited by 11 · see citing works
Subcellular localization of MAK‐V/Hunk protein kinase expressed in COS‐1 cells
Korobko, E. V., Киселев, С. Л., & Korobko, I. V. (2004) · Cell Biology International · doi:10.1016/j.cellbi.2003.10.002 · Cited by 8 · see citing works
Ruzov, A. S., Мерцалов, И. Б., Meehan, R. R., Киселев, С. Л., Buchman, V. L., & Korobko, I. V. (2004) · Development Genes and Evolution · doi:10.1007/s00427-004-0381-9 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Wnt signal transduction pathways
Komiya, Y., & Habas, R. (2008) · Organogenesis · doi:10.4161/org.4.2.5851 · Cited by 1,528 · see citing works
The Frizzled family of unconventional G-protein-coupled receptors
Schulte, G., & Bryja, V. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.09.001 · Cited by 253 · see citing works
Retinal pigment epithelium development, plasticity, and tissue homeostasis
Fuhrmann, S., Zou, C., & Levine, E. M. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.09.003 · Cited by 244 · see citing works
Wnt signaling in eye organogenesis
Fuhrmann, S. (2008) · Organogenesis · doi:10.4161/org.4.2.5850 · Cited by 165 · see citing works
Caneparo, L., Huang, Y., Staudt, N. D., Tada, M., Ahrendt, R., Kazanskaya, O., Niehrs, C., & Houart, C. (2007) · Genes & Development · doi:10.1101/gad.406007 · Cited by 150 · see citing works
Negative regulation of Wnt signaling mediated by CK1‐phosphorylated Dishevelled <i>via</i> Ror2
Witte, F., Bernatik, O., Kirchner, K., Masek, J., Mahl, A., Krejci, P., Mundlos, S., Schambony, A., Bryja, V., & Stricker, S. (2010) · The FASEB Journal · doi:10.1096/fj.09-150615 · Cited by 75 · see citing works
Chapter 7 Convergence and Extension Movements During Vertebrate Gastrulation
Yin, C., Ciruna, B. G., & Solnica‐Krezel, L. (2009) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/s0070-2153(09)89007-8 · Cited by 67 · see citing works
ADAM13 Induces Cranial Neural Crest by Cleaving Class B Ephrins and Regulating Wnt Signaling
Wei, S., Xu, G., Bridges, L. C., Williams, P., White, J. M., & DeSimone, D. W. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.07.012 · Cited by 60 · see citing works
Tuning of β-catenin activity is required to stabilize self-renewal of rat embryonic stem cells
Meek, S. E., Wei, J., Sutherland, L., Nilges, B. S., Buehr, M. L., Tomlinson, S. R., Thomson, A. J., & Burdon, T. (2013) · Stem Cells · doi:10.1002/stem.1466 · Cited by 42 · see citing works
Neural crest specification by noncanonical Wnt signaling and PAR-1
Ossipova, O., & Sokol, S. Y. (2011) · Development · doi:10.1242/dev.067280 · Cited by 35 · see citing works
Self-citationMultiple Requirements of the Focal Dermal Hypoplasia Gene Porcupine during Ocular Morphogenesis
Bankhead, E. J., Colasanto, M. P., Dyorich, K. M., Jamrich, M., Murtaugh, L. C., & Fuhrmann, S. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.09.002 · Cited by 25 · see citing works
Recent advances in neural development
Kiecker, C. M., & Lumsden, A. (2009) · F1000 Biology Reports · doi:10.3410/b1-1 · Cited by 20 · see citing works
Hunk/Mak-v is a negative regulator of intestinal cell proliferation
Reed, K. R., Korobko, I. V., Ninkina, N. N., Korobko, E. V., Hopkins, B. R., Platt, J. L., Buchman, V. L., & Clarke, A. R. (2015) · BMC Cancer · doi:10.1186/s12885-015-1087-2 · Cited by 17 · see citing works
Hofmeister, W., & Key, B. (2013) · Brain Research · doi:10.1016/j.brainres.2013.02.028 · Cited by 14 · see citing works
The Pituitary Transcriptional Response Related to Feed Conversion in Pigs
Piórkowska, K., Żukowski, K., Tyra, M., Szyndler‐Nędza, M., Szulc, K., Skrzypczak, E., & Ropka‐Molik, K. (2019) · Genes · doi:10.3390/genes10090712 · Cited by 12 · see citing works
Expression and molecular diversity of Tcf7l2 in the developing murine cerebellum and brain
Nazwar, T. A., Glassmann, A., & Schilling, K. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.21989 · Cited by 12 · see citing works
MarvelD3 regulates the c-Jun N-terminal kinase pathway during eye development in Xenopus
Vacca, B., Sánchez-Heras, E., Steed, E., Balda, M. S., Ohnuma, S., Sasai, N., Mayor, R., & Matter, K. (2016) · Biology Open · doi:10.1242/bio.018945 · Cited by 10 · see citing works
Pro-survival activity of the MAK-V protein kinase in PC12 cells
Korobko, I. V., Калиниченко, С. В., Korobko, E. V., Ninkina, N. N., Киселев, С. Л., & Buchman, V. L. (2010) · Cell Cycle · doi:10.4161/cc.9.20.13592 · Cited by 8 · see citing works
HUNK Signaling in Metastatic Breast Cancer
Dilday, T., Ramos-Solís, N., & Yeh, E. S. (2020) · Oncoscience · doi:10.18632/oncoscience.504 · Cited by 6 · see citing works
Калиниченко, С. В., Itoh, K., Korobko, E. V., Sokol, S. Y., Buchman, V. L., & Korobko, I. V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039505 · Cited by 6 · see citing works
Self-citationProtein Kinases Involved in the Regulation of Wnt/β-catenin Signaling
Shin, E., Park, E. C., Hong, Y., & Kim, G. (2013) · Journal of Life Science · doi:10.5352/jls.2013.23.7.947 · Cited by 5 · see citing works
Dishevelled at the Crossroads of Pathways
Bryja, V., & Bernatík, O. (2014) · Wiley eBooks · doi:10.1002/9781118444122.ch15 · Cited by 5 · see citing works
Xia, Y., Yu, X., Yuan, Z., Yang, Y. T., & Liu, Y. (2024) · Biology · doi:10.3390/biology13100788 · Cited by 2 · see citing works
Functional properties of a new Wnt11 isoform expressed in colon carcinoma cell line HT29
Posvyatenko, A. V., Kulikova, K. V., Gnuchev, N. V., Georgiev, G. P., Кибардин, А. В., & Larin, S. S. (2012) · Molecular Biology · doi:10.1134/s0026893312010177 · Cited by 1 · see citing works
Mechanisms of Wnt signaling: from embryonic stem cells to dopaminergic neurons
Čajánek, L. (2011) · Figshare
Structure and Function of the H19 Long Non-coding RNA in Cancer
Gungor, Y., Gonul, C. P., & Şentürk, Ş. (2023) · Interdisciplinary cancer research · doi:10.1007/16833_2023_177
Kritikos, A. E., Freije, A. C., & Yeh, E. S. (2025) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2025.103604
- Authors
- Kibardin, A., Ossipova, O., & Sokol, S. Y.
- Affiliations
- Department of Molecular, Cell and Developmental Biology, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.
- Icahn School of Medicine at Mount Sinai (US)
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2006-08-01
- Volume
- 133
- Issue
- 15
- Pages
- 2845-2854
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- PMC
- PMC4428341
- OpenAlex
- W1992613354
- Cited by
- 27
- References
- 89
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2020: 1 · 2019: 1 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 4 · 2012: 2
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS040972)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- Wnt signaling, brain patterning, midbrain-hindbrain boundary, morphogenetic movements, beta-catenin/TCF signaling, Wnt/β-catenin signaling, non-canonical Wnt signaling, eye development, Otx2, EN2, Gbx2, Jun N-terminal kinase, Xenopus embryo
- MeSH terms
- Animals, Brain, Cell Division, Cell Movement, Embryo, Nonmammalian, Eye, Female, Morphogenesis, Phenotype, Xenopus, Protein Serine-Threonine Kinases, DNA Primers, Body Patterning, Reverse Transcriptase Polymerase Chain Reaction, Xenopus Proteins, Wnt Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
