The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis
Abstract
The fibroblast growth factor receptor 2 gene is differentially spliced to encode two transmembrane tyrosine kinase receptor proteins that have different ligandbinding specificities and exclusive tissue distributions. We have used Cre-mediated excision to generate mice lacking the IIIb form of fibroblast growth factor receptor 2 whilst retaining expression of the IIIc form. Fibroblast growth factor receptor 2(IIIb) null mice are viable until birth, but have severe defects of the limbs, lung and anterior pituitary gland. The development of these structures appears to initiate, but then fails with the tissues undergoing extensive apoptosis. There are also developmental abnormalities of the salivary glands, inner ear, teeth and skin, as well as minor defects in skull formation. Our findings point to a key role for fibroblast growth factor receptor 2(IIIb) in mesenchymal-epithelial signalling during early organogenesis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Receptor Specificity of the Fibroblast Growth Factor Family
Ornitz, D. M., Xu, J., Colvin, J. S., McEwen, D. G., MacArthur, C. A., Coulier, F., Gao, G., & Goldfarb, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15292 · Cited by 1,871
Gu, H., Zou, Y.-R., & Rajewsky, K. (1993) · Cell · doi:10.1016/0092-8674(93)90644-6 · Cited by 989
Cited by
The Fibroblast Growth Factor signaling pathway
Ornitz, D. M., & Itoh, N. (2015) · WIREs Developmental Biology · doi:10.1002/wdev.176 · Cited by 2,050
FGF/FGFR signaling in health and disease
Xie, Y., Su, N., Yang, J., Tan, Q., Huang, S., Jin, M., Ni, Z., Zhang, B., Zhang, D., Luo, F., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00222-7 · Cited by 904
Pathogenetic mechanisms in thyroid follicular-cell neoplasia
Kondo, T., Ezzat, S., & Asa, S. L. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1836 · Cited by 893
Functional consequences of developmentally regulated alternative splicing
Kalsotra, A., & Cooper, T. A. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3052 · Cited by 729
Thyroid Development and Its Disorders: Genetics and Molecular Mechanisms
De Felice, M., & Di Lauro, R. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0028 · Cited by 659
Exploring mechanisms of FGF signalling through the lens of structural biology
Goetz, R., & Mohammadi, M. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3528 · Cited by 573
Mechanisms of ectodermal organogenesis.
Pispa, J., & Thesleff, I. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00325-7 · Cited by 499
The pathogenesis of pituitary tumours
Asa, S. L., & Ezzat, S. (2002) · Nature Reviews Cancer · doi:10.1038/nrc926 · Cited by 435
Pituitary Development: Regulatory Codes in Mammalian Organogenesis
Scully, K. M., & Rosenfeld, M. G. (2002) · Science · doi:10.1126/science.1062736 · Cited by 401
Epithelial-Mesenchymal Interactions in the Developing Lung
Shannon, J. M., & Hyatt, B. A. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.032102.135749 · Cited by 321
Different thresholds of fibroblast growth factors pattern the ventral foregut into liver and lung
Serls, A. E., Doherty, S., Parvatiyar, P., Wells, J. M., & Deutsch, G. H. (2005) · Development · doi:10.1242/dev.01570 · Cited by 316
Making a tooth: growth factors, transcription factors, and stem cells
ZHANG, Y. D., CHEN, Z., SONG, Y. Q., LIU, C., & CHEN, Y. P. (2005) · Cell Research · doi:10.1038/sj.cr.7290299 · Cited by 313
Hedgehog signaling is required for pituitary gland development
Treier, M., O’Connell, S., Gleiberman, A., Price, J., Szeto, D. P., Burgess, R., Chuang, P.-T., McMahon, A. P., & Rosenfeld, M. G. (2001) · Development · doi:10.1242/dev.128.3.377 · Cited by 299
Beyond VEGF: Inhibition of the Fibroblast Growth Factor Pathway and Antiangiogenesis
Lieu, C., Heymach, J., Overman, M., Tran, H., & Kopetz, S. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-0659 · Cited by 286
Salivary gland branching morphogenesis
Patel, V. N., Rebustini, I. T., & Hoffman, M. P. (2006) · Differentiation · doi:10.1111/j.1432-0436.2006.00088.x · Cited by 284
Sharp, L. L., Jameson, J. M., Cauvi, G., & Havran, W. L. (2005) · Nature Immunology · doi:10.1038/ni1152 · Cited by 273
Fibroblast Growth Factors In The Developing Central Nervous System
Ford‐Perriss, M., Abud, H., & Murphy, M. (2001) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2001.03477.x · Cited by 264
Fibroblast growth factor (FGF) signaling in development and skeletal diseases
Teven, C. M., Farina, E. M., Rivas, J., & Reid, R. R. (2014) · Genes & Diseases · doi:10.1016/j.gendis.2014.09.005 · Cited by 237
Golzio, C., Martinovic-Bouriel, J., Thomas, S., Mougou-Zrelli, S., Grattagliano-Bessières, B., Bonnière, M., Delahaye, S., Munnich, A., Encha-Razavi, F., Lyonnet, S., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/518177 · Cited by 198
Bailey, A. P., Bhattacharyya, S., Bronner-Fraser, M., & Streit, A. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.08.009 · Cited by 190
Tissue remodelling through branching morphogenesis
Affolter, M., Zeller, R., & Caussinus, E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2797 · Cited by 185
Bebee, T. W., Park, J. W., Sheridan, K. I., Warzecha, C. C., Cieply, B. W., Rohacek, A. M., Xing, Y., & Carstens, R. P. (2015) · eLife · doi:10.7554/elife.08954 · Cited by 161
Sculpting Organs: Mechanical Regulation of Tissue Development
Nelson, C. M., & Gleghorn, J. P. (2012) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071811-150043 · Cited by 130
The Role of Tbx2 and Tbx3 in Mammary Development and Tumorigenesis
Rowley, M., Grothey, E., & Couch, F. J. (2004) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1023/b:jomg.0000037156.64331.3f · Cited by 97
Fibroblast growth factors: key players in epithelial morphogenesis, repair and cytoprotection
Steiling, H., & Werner, S. (2003) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2003.08.003 · Cited by 86
Trowe, M.-O., Zhao, L., Weiss, A.-C., Christoffels, V., Epstein, D. J., & Kispert, A. (2013) · Development · doi:10.1242/dev.094524 · Cited by 72
Fagman, H., Amendola, E., Parrillo, L., Zoppoli, P., Marotta, P., Scarfò, M., De Luca, P., de Carvalho, D. P., Ceccarelli, M., De Felice, M., et al. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.08.015 · Cited by 67
The discovery, function, and regulation of epithelial splicing regulatory proteins (ESRP) 1 and 2
Derham, J. M., & Kalsotra, A. (2023) · Biochemical Society Transactions · doi:10.1042/bst20221124 · Cited by 16
Metadata
- Authors
- Moerlooze, L. D., Spencer-Dene, B., Revest, J.-M., Hajihosseini, M., Rosewell, I., & Dickson, C.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2000-02-01
- Volume
- 127
- Issue
- 3
- Pages
- 483-492
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1930773806
- Cited by
- 864
- References
- 2
- FWCI
- 14.76
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
