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MicroRNAs and their roles in aging

Smith-Vikos, Thalyana, Slack, Frank J.·2012·Journal of Cell Science
DOI 10.1242/jcs.099200
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Abstract

MicroRNAs (miRNAs) are a class of short non-coding RNAs that bind mRNAs through partial base-pair complementarity with their target genes, resulting in post-transcriptional repression of gene expression. The role of miRNAs in controlling aging processes has been uncovered recently with the discovery of miRNAs that regulate lifespan in the nematode Caenorhabditis elegans through insulin and insulin-like growth factor-1 signaling and DNA damage checkpoint factors. Furthermore, numerous miRNAs are differentially expressed during aging in C. elegans, but the specific functions of many of these miRNAs are still unknown. Recently, various miRNAs have been identified that are up- or down-regulated during mammalian aging by comparing their tissue-specific expression in younger and older mice. In addition, many miRNAs have been implicated in governing senescence in a variety of human cell lines, and the precise functions of some of these miRNAs in regulating cellular senescence have helped to elucidate mechanisms underlying aging. In this Commentary, we review the various regulatory roles of miRNAs during aging processes. We highlight how certain miRNAs can regulate aging on the level of organism lifespan, tissue aging or cellular senescence. Finally, we discuss future approaches that might be used to investigate the mechanisms by which miRNAs govern aging processes.

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Metadata

Authors
Smith-Vikos, T., & Slack, F. J.
Affiliations
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
Venue
Journal of Cell Science
Publisher
The Company of Biologists
Published
2012-01-01
Volume
125
Issue
1
Pages
7-17
ISSN
  • 1477-9137
  • 0021-9533
DOI
10.1242/jcs.099200
Cited by
333
References
13
Language
en

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