Aerobic Exercise Alters Skeletal Muscle Molecular Responses to Resistance Exercise

LUNDBERG, TOMMY R.; FERNANDEZ-GONZALO, RODRIGO; GUSTAFSSON, THOMAS; TESCH, PER A.

doi:10.1249/mss.0b013e318256fbe8

Cited by 86Muscle metabolism and nutritionMuscle Physiology and DisordersCardiovascular and exercise physiology

Aerobic Exercise Alters Skeletal Muscle Molecular Responses to Resistance Exercise

LUNDBERG, TOMMY R., FERNANDEZ-GONZALO, RODRIGO, GUSTAFSSON, THOMAS, TESCH, PER A.·2012·Medicine & Science in Sports & Exercise

DOI 10.1249/mss.0b013e318256fbe8

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Abstract

PURPOSE: This study assessed the influence of an acute aerobic exercise bout on molecular responses to subsequent resistance exercise (RE). METHODS: Nine physically active men performed a 45-min one-legged cycle ergometry exercise and 4 × 7 maximal concentric-eccentric knee extensions for each leg 6 h later. Thus, one limb was subjected to aerobic and resistance exercise (AE+RE), and the contralateral limb to resistance exercise (RE) only. Knee extensor peak power was determined. Biopsies were obtained from the m vastus lateralis before (PRE) and 15 min (POST1) and 3 h after RE. Analysis determined glycogen content, mRNA levels (vascular endothelial growth factor, peroxisome proliferator-activated receptor-γ coactivator-1, muscle RING-finger protein-1, atrogin-1, myostatin), and phosphorylated proteins (mammalian target of rapamycin, p70S6 kinase, ribosomal protein S6, eukaryotic elongation factor 2). RESULTS: Peak power was similar in AE + RE and RE. After RE, the time course of glycogen utilization and protein signaling was similar across legs. However, phosphorylation of mammalian target of rapamycin and p70S6 kinase was elevated in AE + RE versus RE (main effect, P < 0.05). Vascular endothelial growth factor and peroxisome proliferator-activated receptor-γ coactivator-1 were higher in AE + RE than in RE at PRE and POST1 (P < 0.05). Myostatin was lower in AE + RE versus RE at PRE and POST1 (P < 0.05) and downregulated after resistance exercise only. Atrogin-1 was higher in AE + RE than in RE at PRE and POST1 (P < 0.05) and decreased after RE in AE + RE. Muscle RING-finger protein-1 was similar across legs. No difference for any marker was evident 3 h after RE. CONCLUSIONS: These results suggest that acute aerobic exercise alters molecular events regulating muscle protein turnover during the early recovery period from subsequent RE.

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“the low-intensity session will not affect signaling pathways regulating strength gains [51–53].”
From Using Molecular Biology to Maximize Concurrent Training (2014) · cites this paper as [52]
Lundberg et al. [52] found no inhibition of mTOR activation when subjects performed 45 min of cycling at 70% VO2max 6 h before resistance exercise.
“Lundberg et al. did not find any inhibition of mTOR activation when subjects performed 45 min of cycling at 70 % VO2max 6 h before performing resistance exercise [52].”
From Using Molecular Biology to Maximize Concurrent Training (2014) · cites this paper as [52]

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The Effects of Acute Aerobic and Resistance Exercise on mTOR Signaling and Autophagy in Human Skeletal Muscle
(2019) · Arizona State University Library Digital Repository (Arizona State University)

Authors: LUNDBERG, T. R., FERNANDEZ-GONZALO, R., GUSTAFSSON, T., & TESCH, P. A.
Affiliations: Mid Sweden University (SE)
Karolinska University Hospital (SE)
Karolinska Institutet (SE)
ORCID: LUNDBERG, TOMMY R.
GUSTAFSSON, THOMAS
Venue: Medicine & Science in Sports & Exercise
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2012-09
Volume: 44
Issue: 9
Pages: 1680-1688
ISSN: 0195-9131 (ISSN-L)
DOI: 10.1249/mss.0b013e318256fbe8
OpenAlex: W2029557372
Cited by: 86
References: 40
Citations by year: 2026: 1 · 2025: 2 · 2024: 3 · 2023: 6 · 2022: 6 · 2021: 3 · 2020: 4 · 2019: 4 · 2018: 7 · 2017: 6 · 2016: 6 · 2015: 14 · 2014: 15 · 2013: 7 · 2012: 1
FWCI: 5.60
Type: journal article
Language: en
Open access: closed
Locations: Medicine & Science in Sports & Exercise (publishedVersion, public-domain)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Keywords: aerobic exercise, resistance training, skeletal muscle, muscle protein turnover, mTOR signaling, p70 S6 kinase, ribosomal protein S6, elongation factor 2, myostatin, atrogin-1, vascular endothelial growth factor, PPAR-gamma coactivator 1, muscle glycogen, vastus lateralis, knee extension, post-exercise recovery
MeSH terms: Adult, Glycogen, Humans, Male, Muscle Proteins, Phosphorylation, RNA, Messenger, Blotting, Western, Exercise, Ergometry, Muscle, Skeletal, Resistance Training, Young Adult, Real-Time Polymerase Chain Reaction

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Aerobic Exercise Alters Skeletal Muscle Molecular Responses to Resistance Exercise

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