Advances in Neuroprosthetic Learning and Control
Open accessAbstract
Significant progress has occurred in the field of brain-machine interfaces (BMI) since the first demonstrations with rodents, monkeys, and humans controlling different prosthetic devices directly with neural activity. This technology holds great potential to aid large numbers of people with neurological disorders. However, despite this initial enthusiasm and the plethora of available robotic technologies, existing neural interfaces cannot as yet master the control of prosthetic, paralyzed, or otherwise disabled limbs. Here I briefly discuss recent advances from our laboratory into the neural basis of BMIs that should lead to better prosthetic control and clinically viable solutions, as well as new insights into the neurobiology of action.
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Frequent or continuous recalibration, especially when accompanied by re-selecting the classifier's features, creates a situation in which the subject's learning could be hindered by the demand to adapt to a continuously changing decoder.
“Frequent or continuous recalibration, especially in case it is accompanied by re-selecting the classifier’s features, creates a situation in which the subject’s learning could be hindered by the demand to adapt to a continuously changing decoder [29,70].”
From The Cybathlon BCI race: Successful longitudinal mutual learning with two tetraplegic users (2018) · cites this paper as [70]
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Cites
Millisecond-timescale, genetically targeted optical control of neural activity
Boyden, E. S., Zhang, F., Bamberg, E., Nagel, G., & Deisseroth, K. A. (2005) · Nature Neuroscience · doi:10.1038/nn1525 · Cited by 4,831 · see citing works
Neuronal ensemble control of prosthetic devices by a human with tetraplegia
Hochberg, L. R., Serruya, M. D., Friehs, G. M., Mukand, J. A., Saleh, M., Caplan, A. H., Branner, A., Chen, D., Penn, R. D., & Donoghue, J. P. (2006) · Nature · doi:10.1038/nature04970 · Cited by 3,295 · see citing works
Reach and grasp by people with tetraplegia using a neurally controlled robotic arm
Hochberg, L. R., Bacher, D., Jarosiewicz, B., Masse, N. Y., Simeral, J. D., Vogel, J., Haddadin, S., Liu, J., Cash, S. S., van der Smagt, P., et al. (2012) · Nature · doi:10.1038/nature11076 · Cited by 2,719 · see citing works
High-performance neuroprosthetic control by an individual with tetraplegia
Collinger, J. L., Wodlinger, B., Downey, J. E., Wang, W., Tyler-Kabara, E. C., Weber, D. J., McMorland, A. J., Velliste, M., Boninger, M. L., & Schwartz, A. B. (2013) · The Lancet · doi:10.1016/s0140-6736(12)61816-9 · Cited by 1,848 · see citing works
Learning to control a brain–machine interface for reaching and grasping by primates
Carmena, J. M., Lebedev, M. A., Crist, R. E., O'Doherty, J. E., Santucci, D. M., Dimitrov, D. F., Patil, P. G., Henriquez, C. S., & Nicolelis, M. A. L. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000042 · Cited by 1,761 · see citing works
Self-citationCortical control of a prosthetic arm for self-feeding
Velliste, M., Perel, S., Spalding, M. C., Whitford, A. S., & Schwartz, A. B. (2008) · Nature · doi:10.1038/nature06996 · Cited by 1,591 · see citing works
Direct Cortical Control of 3D Neuroprosthetic Devices
Taylor, D. M., Tillery, S. I. H., & Schwartz, A. B. (2002) · Science · doi:10.1126/science.1070291 · Cited by 1,542 · see citing works
Instant neural control of a movement signal
Serruya, M. D., Hatsopoulos, N. G., Paninski, L., Fellows, M. R., & Donoghue, J. P. (2002) · Nature · doi:10.1038/416141a · Cited by 1,415 · see citing works
A brain–computer interface using electrocorticographic signals in humans
Leuthardt, E. C., Schalk, G., Wolpaw, J. R., Ojemann, J. G., & Moran, D. W. (2004) · Journal of Neural Engineering · doi:10.1088/1741-2560/1/2/001 · Cited by 1,188 · see citing works
Real-time control of a robot arm using simultaneously recorded neurons in the motor cortex
Chapin, J. K., Moxon, K. A., Markowitz, R. S., & Nicolelis, M. A. L. (1999) · Nature Neuroscience · doi:10.1038/10223 · Cited by 1,168 · see citing works
A high-performance brain–computer interface
Santhanam, G., Ryu, S. I., Yu, B. M., Afshar, A., & Shenoy, K. V. (2006) · Nature · doi:10.1038/nature04968 · Cited by 698 · see citing works
Cognitive Control Signals for Neural Prosthetics
Musallam, S., Corneil, B. D., Greger, B., Scherberger, H., & Andersen, R. A. (2004) · Science · doi:10.1126/science.1097938 · Cited by 663 · see citing works
Operant Conditioning of Cortical Unit Activity
Fetz, E. E. (1969) · Science · doi:10.1126/science.163.3870.955 · Cited by 631 · see citing works
Active tactile exploration using a brain–machine–brain interface
O’Doherty, J. E., Lebedev, M. A., Ifft, P. J., Zhuang, K. Z., Shokur, S., Bleuler, H., & Nicolelis, M. A. L. (2011) · Nature · doi:10.1038/nature10489 · Cited by 629 · see citing works
Direct control of paralysed muscles by cortical neurons
Moritz, C. T., Perlmutter, S. I., & Fetz, E. E. (2008) · Nature · doi:10.1038/nature07418 · Cited by 602 · see citing works
Emergence of a stable cortical map for neuroprosthetic control
Ganguly, K., & Carmena, J. M. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000153 · Cited by 578 · see citing works
Self-citationA high-performance neural prosthesis enabled by control algorithm design
Gilja, V., Nuyujukian, P., Chestek, C. A., Cunningham, J. P., Yu, B. M., Fan, J. M., Churchland, M. M., Kaufman, M. T., Kao, J. C., Ryu, S. I., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3265 · Cited by 564 · see citing works
Restoration of grasp following paralysis through brain-controlled stimulation of muscles
Ethier, C., Oby, E. R., Bauman, M. J., & Miller, L. E. (2012) · Nature · doi:10.1038/nature10987 · Cited by 485 · see citing works
Corticostriatal plasticity is necessary for learning intentional neuroprosthetic skills
Koralek, A. C., Jin, X., Long, J. D., II, Costa, R. M., & Carmena, J. M. (2012) · Nature · doi:10.1038/nature10845 · Cited by 373 · see citing works
Self-citationPrasad, A., Xue, Q.-S., Sankar, V., Nishida, T., Shaw, G., Streit, W. J., & Sanchez, J. C. (2012) · Journal of Neural Engineering · doi:10.1088/1741-2560/9/5/056015 · Cited by 298 · see citing works
Volitional control of neural activity: implications for brain–computer interfaces
Fetz, E. E. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2006.127142 · Cited by 266 · see citing works
Reversible large-scale modification of cortical networks during neuroprosthetic control
Ganguly, K., Dimitrov, D. F., Wallis, J. D., & Carmena, J. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2797 · Cited by 259 · see citing works
Self-citationA Glucose Fuel Cell for Implantable Brain–Machine Interfaces
Rapoport, B. I., Kedzierski, J. T., & Sarpeshkar, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038436 · Cited by 244 · see citing works
Incorporating Feedback from Multiple Sensory Modalities Enhances Brain–Machine Interface Control
Suminski, A. J., Tkach, D. C., Fagg, A. H., & Hatsopoulos, N. G. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3967-10.2010 · Cited by 232 · see citing works
Orsborn, A. L., Dangi, S., Moorman, H. G., & Carmena, J. M. (2012) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2012.2185066 · Cited by 171 · see citing works
Self-citationAdaptive Decoding for Brain-Machine Interfaces Through Bayesian Parameter Updates
Li, Z., O’Doherty, J. E., Lebedev, M., & Nicolelis, M. A. L. (2011) · Neural Computation · doi:10.1162/neco_a_00207 · Cited by 129 · see citing works
Naïve coadaptive cortical control
Gage, G. J., Ludwig, K. A., Otto, K. J., Ionides, E. L., & Kipke, D. R. (2005) · Journal of Neural Engineering · doi:10.1088/1741-2560/2/2/006 · Cited by 110 · see citing works
Design and analysis of closed-loop decoder adaptation algorithms for brain-machine interfaces
Dangi, S., Orsborn, A. L., Moorman, H. G., & Carmena, J. M. (2013) · Neural Computation · doi:10.1162/neco_a_00460 · Cited by 103 · see citing works
Self-citationA Symbiotic Brain-Machine Interface through Value-Based Decision Making
Mahmoudi, B., & Sanchez, J. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0014760 · Cited by 88 · see citing works
Active sensing of target location encoded by cortical microstimulation
Venkatraman, S., & Carmena, J. M. (2011) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2011.2117441 · Cited by 66 · see citing works
Self-citationBundy, D. T., Wronkiewicz, M., Sharma, M., Moran, D. W., Corbetta, M., & Leuthardt, E. C. (2012) · Journal of Neural Engineering · doi:10.1088/1741-2560/9/3/036011 · Cited by 64 · see citing works
Kernel-ARMA for Hand Tracking and Brain-Machine interfacing During 3D Motor Control
Shpigelman, L., Lalazar, H., & Vaadia, E. (2008) · Cited by 60 · see citing works
Interfacing With the Computational Brain
Andrew, J. O., & Fetz, E. E. (2011) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2011.2158586 · Cited by 54 · see citing works
Neural Correlates of Skill Acquisition with a Cortical Brain–Machine Interface
Ganguly, K., & Carmena, J. M. (2010) · Journal of Motor Behavior · doi:10.1080/00222895.2010.526457 · Cited by 49 · see citing works
Self-citationMonkey models for brain-machine interfaces: The need for maintaining diversity
Nuyujukian, P., Fan, J. M., Gilja, V., Kalanithi, P. S. A., Chestek, C. A., & Shenoy, K. V. (2011) · Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) · doi:10.1109/iembs.2011.6090306 · Cited by 26 · see citing works
Knudsen, E. B., Moxon, K. A., Sturgis, E. B., et al. (2011) · doi:10.1109/iembs.2011.6091558 · Cited by 7 · see citing works
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Closed-Loop Decoder Adaptation Shapes Neural Plasticity for Skillful Neuroprosthetic Control
Orsborn, A. L., Moorman, H. G., Overduin, S. A., Shanechi, M. M., Dimitrov, D. F., & Carmena, J. M. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.048 · Cited by 280 · see citing works
Self-citationThe Cybathlon BCI race: Successful longitudinal mutual learning with two tetraplegic users
Perdikis, S., Tonin, L., Saeedi, S., Schneider, C., & Millán, J. D. R. (2018) · PLOS Biology · doi:10.1371/journal.pbio.2003787 · Cited by 166 · see citing works
Borton, D., Micera, S., Millán, J. D. R., & Courtine, G. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005968 · Cited by 171 · see citing works
Clinical applications of penetrating neural interfaces and Utah Electrode Array technologies
Normann, R. A., & Fernandez, E. (2016) · Journal of Neural Engineering · doi:10.1088/1741-2560/13/6/061003 · Cited by 135 · see citing works
Context-aware adaptive spelling in motor imagery BCI
Perdikis, S., Leeb, R., & Millán, J. D. R. (2016) · Journal of Neural Engineering · doi:10.1088/1741-2560/13/3/036018 · Cited by 49 · see citing works
Brain-Machine Interfaces: The Perception-Action Closed Loop: A Two-Learner System
Millan, J. D. R. (2015) · IEEE Systems, Man, and Cybernetics Magazine · doi:10.1109/msmc.2014.2386901 · Cited by 19 · see citing works
- Authors
- Carmena, J. M.
- Affiliations
- University of California, Berkeley (US)
- Corresponding author
- Carmena, Jose M.
- ORCID
- Carmena, Jose M.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-05-21
- Volume
- 11
- Issue
- 5
- Pages
- e1001561
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- PMC
- PMC3660243
- OpenAlex
- W2172103792
- Cited by
- 117
- References
- 36
- Citations by year
- 2025: 3 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 6 · 2020: 11 · 2019: 5 · 2018: 11 · 2017: 6 · 2016: 16 · 2015: 15 · 2014: 26 · 2013: 8
- FWCI
- 11.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Hispana (submittedVersion, cc-by)
- Funders
- National Science Foundation (0954243, CAREER, N66001-10-C-2008)
- Alfred P. Sloan Foundation
- Christopher and Dana Reeve Foundation
- Defense Advanced Research Projects Agency (N66001-10-C-2008)
- Advanced Research Projects Agency
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neural Engineering
- Physical Sciences › Engineering › Biomedical Engineering › Muscle activation and electromyography studies
- Keywords
- brain-computer interface, neuroprosthetics, prosthetic control, neural decoding, paralysis, neurological disorders, robotic prosthetics
- MeSH terms
- Animals, Haplorhini, Artificial Intelligence, Humans, Robotics, User-Computer Interface, Neural Prostheses
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