Encoding of fear learning and memory in distributed neuronal circuits

Herry, Cyril; Johansen, Joshua P

doi:10.1038/nn.3869

Cited by 474Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchMemory Processes and Influences

Encoding of fear learning and memory in distributed neuronal circuits

Herry, Cyril, Johansen, Joshua P·2014·Nature Neuroscience

DOI 10.1038/nn.3869

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Abstract

How sensory information is transformed by learning into adaptive behaviors is a fundamental question in neuroscience. Studies of auditory fear conditioning have revealed much about the formation and expression of emotional memories and have provided important insights into this question. Classical work focused on the amygdala as a central structure for fear conditioning. Recent advances, however, have identified new circuits and neural coding strategies mediating fear learning and the expression of fear behaviors. One area of research has identified key brain regions and neuronal coding mechanisms that regulate the formation, specificity and strength of fear memories. Other work has discovered critical circuits and neuronal dynamics by which fear memories are expressed through a medial prefrontal cortex pathway and coordinated activity across interconnected brain regions. Here we review these recent advances alongside prior work to provide a working model of the extended circuits and neuronal coding mechanisms mediating fear learning and memory.

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The amygdala is central to a distributed neural circuitry orchestrating Pavlovian fear conditioning in humans and other species.
“The amygdala-an ensemble of functionally distinct nuclei located in the medial temporal lobe-is central to a distributed neural circuitry orchestrating Pavlovian fear conditioning in humans and other species, underscoring its crucial role in promoting reproductive fitness (Herry and Johansen, 2014).”
From Oxytocin Facilitates Pavlovian Fear Learning in Males (2016) · cites this paper as Herry and Johansen, 2014
Activity in pathways from the mPFC and vHPC to the BLA can both directly invigorate the anxiety response and influence the likelihood of a threat appraisal.
“Activity in these pathways can both directly invigorate the anxiety response (for example, through projections of the vHPC to the lateral septum and hypothalamic nuclei; see below), as well as influence the likelihood of a threat appraisal (for example, through fear-memory retrieval via mPFC projections to the amygdala; see below and ref. 69).”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [69]

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EXTENDED FEAR CONDITIONING REVEALS A ROLE FOR BOTH N-METHYL-d-ASPARTIC ACID AND NON-N-METHYL-d-ASPARTIC ACID RECEPTORS IN THE AMYGDALA IN THE ACQUISITION OF CONDITIONED FEAR
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Authors: Herry, C., & Johansen, J. P.
Affiliations: Inserm (FR)
RIKEN Center for Brain Science (JP)
Corresponding author: Herry, Cyril
Johansen, Joshua P
ORCID: Herry, Cyril
Johansen, Joshua P
Venue: Nature Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2014-11-21
Volume: 17
Issue: 12
Pages: 1644-1654
ISSN: 1097-6256 (ISSN-L)
1546-1726
DOI: 10.1038/nn.3869
OpenAlex: W2089767272
Cited by: 474
References: 120
Citations by year: 2026: 25 · 2025: 33 · 2024: 35 · 2023: 50 · 2022: 40 · 2021: 46 · 2020: 44 · 2019: 46 · 2018: 42 · 2017: 37 · 2016: 38 · 2015: 37 · 2014: 1
FWCI: 3.65
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords: fear conditioning, fear memory, amygdala, auditory fear conditioning, neural coding, medial prefrontal cortex, emotional memory, fear expression, memory specificity
MeSH terms: Amygdala, Animals, Auditory Pathways, Brain, Fear, Humans, Learning, Memory, Neural Pathways, Neurons

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Encoding of fear learning and memory in distributed neuronal circuits

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