Sleep-Wake Cycle in Young and Older Persons with a Lifetime History of Mood Disorders
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Considering the marked changes in sleep and circadian rhythms across the lifespan, age may contribute to the heterogeneity in sleep-wake profiles linked to mood disorders. This study aimed to investigate the contributions of age and depression severity to sleep-wake disturbances. The Hamilton Depression Rating Scale (HDRS) was administered to assess current symptoms severity in 238 persons with a history of a mood disorder between 12 and 90 years of age (y.o.). Actigraphy was recorded over five to 22 days. Regression analyses and analyses of variance [age (12-19 y.o., 20-39 y.o., 40-59 y.o., and ≥ 60 y.o.) by depression severity (HDRS< and ≥ 8)] were conducted. The 12-19 y.o. and 20-39 y.o. groups had a delayed sleep schedule and acrophase compared to all other groups. The ≥ 60 y.o. group had a lower rhythmicity and amplitude (p ≤ .006) than the 12-19 y.o. group (p ≤ .046). Participants with a HDRS ≥ 8 spent longer time in bed, had later sleep offset times and had lower circadian rhythmicity than those with a HDRS<8 (p ≤ .036). Younger age and higher HDRS score correlated with later sleep onset and offset times, longer time in bed, higher WASO, lower sleep efficiency and later acrophase (p ≤ .023). Age was a significant predictor of delayed sleep and activity schedules (p ≤ .001). The profile of sleep-wake cycle disturbances associated with mood disorders changes with age, with prominent sleep phase delay during youth and reduced circadian strength in older persons. Conversely, disruptions in sleep consolidation seem more stable across age.
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Later sleep midpoint and offset time were associated with more severe depressive symptoms.
“the analysis of sleep data showed that later sleep midpoint and offset time were associated with more severe depressive symptoms”
From Digital Biomarkers for Depression Screening With Wearable Devices: Cross-sectional Study With Machine Learning Modeling (2021) · cites this paper as [22]
Among cosinor-based metrics, lower pseudo-F statistic values and later acrophase, both based on steps and heart rate, were associated with more severe symptoms, but these correlations became nonsignificant after FDR correction and in multiple regression analysis.
“our data indicated lower pseudo-F statistic values and later acrophase, both based on steps and heart rate, in participants with more severe symptoms, which is consistent with existing evidence [22,23,25,26,29,30], yet these correlations became nonsignificant after the FDR correction and in multiple regression analysis.”
From Digital Biomarkers for Depression Screening With Wearable Devices: Cross-sectional Study With Machine Learning Modeling (2021) · cites this paper as [22]
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Cites
The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90047-4 · Cited by 35,234 · see citing works
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
Ohayon, M. M., Carskadon, M. A., Guilleminault, C., & Vitiello, M. V. (2004) · Sleep · doi:10.1093/sleep/27.7.1255 · Cited by 3,349 · see citing works
Sleep Complaints Among Elderly Persons: An Epidemiologic Study of Three Communities
Foley, D. J., Monjan, A. A., Brown, S. L., Simonsick, E. M., Wallace, R. B., & Blazer, D. G. (1995) · Sleep · doi:10.1093/sleep/18.6.425 · Cited by 1,610 · see citing works
Sleep and Psychiatric Disorders: A Meta-analysis
Benca, R. M. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820080059010 · Cited by 1,468 · see citing works
Sleep Duration From Infancy to Adolescence: Reference Values and Generational Trends
Iglowstein, I., Jenni, O. G., Molinari, L., & Largo, R. H. (2003) · PEDIATRICS · doi:10.1542/peds.111.2.302 · Cited by 1,318 · see citing works
Physical activity, exercise, depression and anxiety disorders
Ströhle, A. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-008-0092-x · Cited by 1,269 · see citing works
Antidepressant and Circadian Phase-Shifting Effects of Light
Lewy, A. J., Sack, R. L., Miller, L. S., & Hoban, T. M. (1987) · Science · doi:10.1126/science.3798117 · Cited by 709 · see citing works
Association between physical activity and mental disorders among adults in the United States
Goodwin, R. D. (2003) · Preventive Medicine · doi:10.1016/s0091-7435(03)00042-2 · Cited by 675 · see citing works
Circadian rhythm disturbances in depression
Germain, A., & Kupfer, D. J. (2008) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.964 · Cited by 644 · see citing works
Stephens, T. (1988) · Preventive Medicine · doi:10.1016/0091-7435(88)90070-9 · Cited by 544 · see citing works
Self-reported sleep disturbance as a prodromal symptom in recurrent depression
Perlis, M. L., Giles, D. E., Buysse, D. J., Tu, X. M., & Kupfer, D. J. (1997) · Journal of Affective Disorders · doi:10.1016/s0165-0327(96)01411-5 · Cited by 523 · see citing works
Dijk, D., Duffy, J. F., Riel, E., Shanahan, T. L., & Czeisler, C. A. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0611v.x · Cited by 467 · see citing works
The effects of acute exercise on sleep: a quantitative synthesis
Youngstedt, S. D., O'Connor, P. J., & Dishman, R. K. (1997) · Sleep · doi:10.1093/sleep/20.3.203 · Cited by 412 · see citing works
Running versus weight lifting in the treatment of depression.
Doyne, E. J., Ossip-Klein, D. J., Bowman, E. D., Osborn, K. M., McDougall-Wilson, I. B., & Neimeyer, R. A. (1987) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.55.5.748 · Cited by 326 · see citing works
Novel melatonin-based therapies: potential advances in the treatment of major depression
Hickie, I. B., & Rogers, N. L. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60095-0 · Cited by 322 · see citing works
Self-citationSleep Disturbance and Depression Recurrence in Community-Dwelling Older Adults: A Prospective Study
Cho, H. J., Lavretsky, H., Olmstead, R., Levin, M. J., Oxman, M. N., & Irwin, M. R. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2008.07121882 · Cited by 318 · see citing works
Age-associated difference in circadian sleep–wake and rest–activity rhythms
Huang, Y.-L., Liu, R., Wang, Q., Someren, E. J. W. V., Xu, H., & Zhou, J. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00733-3 · Cited by 291 · see citing works
Campbell, I. G., & Feinberg, I. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812947106 · Cited by 280 · see citing works
Sleep and psychiatric disorders
Billiard, M. M., Partinen, M., Roth, T. G., & Shapiro, C. M. (1994) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(94)90129-5 · Cited by 278 · see citing works
How Sleep and Mental Disorders Are Related to Complaints of Daytime Sleepiness
Ohayon, M. M. (1997) · Archives of Internal Medicine · doi:10.1001/archinte.1997.00440430127015 · Cited by 271 · see citing works
Naismith, S. L., Norrie, L. M., Mowszowski, L., & Hickie, I. B. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.05.009 · Cited by 269 · see citing works
Self-citationPhysical activity, exercise coping, and depression in a 10-year cohort study of depressed patients
Harris, A. H. S., Cronkite, R. C., & Moos, R. H. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.02.013 · Cited by 258 · see citing works
From early to late adulthood changes in EEG sleep of depressed patients and healthy volunteers
Lauer, C. J., Riemann, D. W., Wiegand, M. H., & Berger, M. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)90355-p · Cited by 247 · see citing works
Sleep and the transition to adolescence: a longitudinal study
Sadeh, A., Dahl, R. E., Shahar, G., & Rosenblat-Stein, S. (2009) · SLEEP · doi:10.1093/sleep/32.12.1602 · Cited by 243 · see citing works
Running versus weight lifting in the treatment of depression.
Doyne, E. J., Ossip-Klein, D. J., Bowman, E. D., et al. (1987) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.55.5.748 · Cited by 231 · see citing works
Age-related changes in sleep in depressed and normal subjects
Gillin, J. C., Duncan, W. C., Murphy, D. L., Post, R. M., Wehr, T. A., Goodwin, F. K., Wyatt, R. J., & Bunney, W. E. (1981) · Psychiatry Research · doi:10.1016/0165-1781(81)90010-x · Cited by 222 · see citing works
The effects of depression and age on the Horne-Ostberg morningness-eveningness score
Drennan, M. D., Klauber, M. R., Kripke, D. F., & Goyette, L. M. (1991) · Journal of Affective Disorders · doi:10.1016/0165-0327(91)90096-b · Cited by 215 · see citing works
Marler, M., Gehrman, P., Martin, J. L., & Ancoli‐Israel, S. (2005) · Statistics in Medicine · doi:10.1002/sim.2466 · Cited by 209 · see citing works
Circadian Phase Variation in Bipolar I Disorder
Mansour, H. A., Wood, J., Chowdari, K. V., Dayal, M., Thase, M. E., Kupfer, D. J., Monk, T. H., Devlin, B., & Nimgaonkar, V. L. (2005) · Chronobiology International · doi:10.1081/cbi-200062413 · Cited by 204 · see citing works
Physical Inactivity and Depression in the Community
Weyerer, S. B. (1992) · International Journal of Sports Medicine · doi:10.1055/s-2007-1021304 · Cited by 189 · see citing works
Slow-Wave Sleep: A Recovery Period After Exercise
Shapiro, C. M., Bortz, R., Mitchell, D., Bartel, P., & Jooste, P. L. (1981) · Science · doi:10.1126/science.7302594 · Cited by 178 · see citing works
Glozier, N., Martiniuk, A., Patton, G., Ivers, R., Li, Q., Hickie, I., Senserrick, T., Woodward, M., Norton, R., & Stevenson, M. (2010) · Sleep · doi:10.1093/sleep/33.9.1139 · Cited by 177 · see citing works
Self-citationSleep disruption and mood changes associated with menopause
Baker, A., Simpson, S., & Dawson, D. E. (1997) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(97)00126-8 · Cited by 172 · see citing works
Delayed sleep phase in young people with unipolar or bipolar affective disorders
Robillard, R., Naismith, S. L., Rogers, N. L., Ip, T. K. C., Hermens, D. F., Scott, E. M., & Hickie, I. B. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.06.006 · Cited by 172 · see citing works
Self-citationALTERATIONS WITH AGING OF THE ENDOCRINE AND NEUROENDOCRINE CIRCADIAN SYSTEM IN HUMANS
Touitou, Y., & Haus, E. L. (2000) · Chronobiology International · doi:10.1081/cbi-100101052 · Cited by 169 · see citing works
Effects of Stimulated Physical Activity on the Circadian Pacemaker of Vertebrates 1
Turek, F. W. (1989) · Journal of Biological Rhythms · doi:10.1177/074873048900400204 · Cited by 163 · see citing works
EEG studies of sleep in the diagnosis of depression.
Feinberg, M. P., Gillin, J. C., Carroll, B. J., Greden, J. F., & Zis, A. P. (1982) · PubMed · Cited by 156 · see citing works
Sleep and Psychological Characteristics of Children on a Psychiatric Inpatient Unit
Sadeh, A., McGuire, J. P. D., Sachs, H. T., Seifer, R., Tremblay, A., Civita, R., & Hayden, R. M. (1995) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199506000-00023 · Cited by 155 · see citing works
Aging in the circadian system: Considerations for health, disease prevention and longevity
Gibson, E. M., Williams, W. P., & Kriegsfeld, L. J. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.05.007 · Cited by 155 · see citing works
Targeted primary care‐based mental health services for young Australians
Scott, E. M., Hermens, D. F., Glozier, N., Naismith, S. L., Guastella, A. J., & Hickie, I. B. (2012) · Medical Journal of Australia · doi:10.5694/mja11.10481 · Cited by 155 · see citing works
Self-citationSleep habits and sleep disturbances among the elderly—an epidemiological survey
Gíslason, Þ., REYNISDÓTTIR, H., Kristbjarnarson, H., & Benediktsdóttir, B. (1993) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1993.tb00701.x · Cited by 148 · see citing works
Hickie, I. B., Naismith, S. L., Robillard, R., Scott, E. M., & Hermens, D. F. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-79 · Cited by 148 · see citing works
Self-citationFatigue in selected primary care settings: sociodemographic and psychiatric correlates
Hickie, I. B., Hooker, A. W., Bennett, B. K., Hadži-Pavlović, D., Wilson, A. J., & Lloyd, A. R. (1996) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1996.tb122199.x · Cited by 147 · see citing works
Self-citationRobillard, R., Naismith, S. L., Rogers, N. L., Scott, E. M., Ip, T. K. C., Hermens, D. F., & Hickie, I. B. (2013) · European Psychiatry · doi:10.1016/j.eurpsy.2013.04.001 · Cited by 141 · see citing works
Self-citationClinical aspects of human circadian rhythms
Klerman, E. B. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730405278353 · Cited by 139 · see citing works
Insomnia and depression: a multifaceted interplay
Manber, R., & Chambers, A. S. (2009) · Current Psychiatry Reports · doi:10.1007/s11920-009-0066-1 · Cited by 134 · see citing works
Electroencephalographic sleep correlates of episode and vulnerability to recurrence in depression
Buysse, D. J., Frank, E., Lowe, K. K., Cherry, C. R., & Kupfer, D. J. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00041-8 · Cited by 130 · see citing works
Late-onset depression: genetic, vascular and clinical contributions
Hickie, I. B., Scott, E. M., Naismith, S. L., Ward, P. B., Turner, K. A., Parker, G. B., Mitchell, P. B., & Wilhelm, K. A. (2001) · Psychological Medicine · doi:10.1017/s0033291701004731 · Cited by 122 · see citing works
Self-citationSleep Well, Think Well: Sleep-Wake Disturbance in Mild Cognitive Impairment
Naismith, S. L., Rogers, N. L., Hickie, I. B., Mackenzie, J., Norrie, L. M., & Lewis, S. J. G. (2010) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988710363710 · Cited by 118 · see citing works
Self-citationPhysical exercise performed before bedtime improves the sleep pattern of healthy young good sleepers
Flausino, N. H., Prado, J. M. D. S., de Queiroz, S. S., Tufik, S., & de Mello, M. T. (2011) · Psychophysiology · doi:10.1111/j.1469-8986.2011.01300.x · Cited by 114 · see citing works
Bertocci, M. A., Dahl, R. E., Williamson, D. E., Iosif, A., Birmaher, B. B., Axelson, D., & Ryan, N. D. (2005) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000179057.54419.17 · Cited by 112 · see citing works
Manber, R., Rush, A. J., Thase, M. E., Arnow, B., Klein, D., Trivedi, M. H., Korenstein, S. G., Markowitz, J. C., Dunner, D. L., Munsaka, M., et al. (2003) · SLEEP · doi:10.1093/sleep/26.2.130 · Cited by 102 · see citing works
Epidemiology of exercise effects on sleep.
Vuori, I., Urponen, H., Hasan, J., & Partinen, M. (1988) · PubMed · Cited by 97 · see citing works
Benedetti, F., Dallaspezia, S., Fulgosi, M. C., Barbini, B., Colombo, C., & Smeraldi, E. (2007) · Chronobiology International · doi:10.1080/07420520701649455 · Cited by 97 · see citing works
Zhang, J., Lamers, F., Hickie, I. B., He, J.-P., Feig, E. H., & Merikangas, K. R. (2013) · SLEEP · doi:10.5665/sleep.2624 · Cited by 90 · see citing works
Self-citationSleep disturbance relates to neuropsychological functioning in late-life depression
Naismith, S. L., Rogers, N. L., Lewis, S. J. G., Terpening, Z., Ip, T. K. C., Diamond, K., Norrie, L. M., & Hickie, I. B. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.02.027 · Cited by 87 · see citing works
Self-citationScott, E. M., Naismith, S. L., Whitwell, B. G., Hamilton, B. A., Chudleigh, C., & Hickie, I. B. (2009) · Australasian Psychiatry · doi:10.1080/10398560802657322 · Cited by 85 · see citing works
Self-citationPhase advance of sleep and temperature circadian rhythms in the middle years of life in humans
Carrier, J., Paquet, J., Morettini, J., & Touchette, É. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00038-1 · Cited by 81 · see citing works
Age-related changes in sleep in depressed and healthy subjects. A meta-analysis.
Knowles, J. B., & MacLean, A. (1990) · PubMed · Cited by 78 · see citing works
Circadian profiles in young people during the early stages of affective disorder
Naismith, S. L., Hermens, D. F., Ip, T. K. C., Bolitho, S., Scott, E. M., Rogers, N. L., & Hickie, I. B. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.47 · Cited by 72 · see citing works
Self-citationSex and Age Differences in Sleep Macroarchitecture in Childhood and Adolescent Depression
Robert, J. J. T., Hoffmann, R. F., Emslie, G. J., Hughes, C. W., Rintelmann, J. W., Moore, J., & Armitage, R. (2006) · SLEEP · doi:10.1093/sleep/29.3.351 · Cited by 68 · see citing works
EEG sleep and severity of depression.
Dg, S., Coble, P. A., Cofsky, J., Fg, F., & Dj, K. (1978) · PubMed · Cited by 55 · see citing works
Wirz‐Justice, A. (2009) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.04.024 · Cited by 51 · see citing works
Principles and Practice of Geriatric Sleep Medicine
(2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511770661 · Cited by 50 · see citing works
Exercise and Human Circadian Rhythms: What we Know and What we Need to Know
Redlin, U., & Mrosovsky, N. (1997) · Chronobiology International · doi:10.3109/07420529709001157 · Cited by 50 · see citing works
Hickie, I. B., Naismith, S. L., Ward, P. B., Little, C. L., Pearson, M., Scott, E. M., Mitchell, P. B., Wilhelm, K. A., & Parker, G. B. (2007) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.01.006 · Cited by 49 · see citing works
Self-citationMultivariate study of sleep EEG in depression
Kerkhofs, M., Kempenaers, C., Linkowski, P., Maertelaer, V. D., & MENDLEWICZ, J. (1988) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1988.tb05152.x · Cited by 41 · see citing works
Nowakowski, S., Meliska, C. J., Martinez, L. F., & Parry, B. L. (2009) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-009-0025-6 · Cited by 40 · see citing works
Robillard, R., Massicotte-Marquez, J., Kawinska, A., Paquet, J., Frenette, S., & Carrier, J. (2010) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2010.00820.x · Cited by 36 · see citing works
Self-citationActigraphic Predictors of Depressed Mood in a Cohort of Non-Psychiatric Adults
Mendlowicz, M. V., Jean‐Louis, G., von Gizycki, H., Zizi, F., & Nunes, J. (1999) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/j.1440-1614.1999.00585.x · Cited by 33 · see citing works
Managing depression across the life cycle: new strategies for clinicians and their patients
Hickie, I. B., Naismith, S. L., Norrie, L. M., & Scott, E. M. (2009) · Internal Medicine Journal · doi:10.1111/j.1445-5994.2009.02016.x · Cited by 27 · see citing works
Self-citationSelf Report of Sleep Symptoms in Older Adults: Correlates of Daytime Sleepiness and Health
Schmitt, F. A., Phillips, B. A., Cook, Y. R., Berry, D. T. R., & Wekstein, D. R. (1996) · SLEEP · doi:10.1093/sleep/19.1.59 · Cited by 26 · see citing works
Sleep EEG, the Clearest Window through which to View Adolescent Brain Development
Colrain, I. M., & Baker, F. C. (2011) · SLEEP · doi:10.5665/sleep.1260 · Cited by 9 · see citing works
Aging and circadian rhythms: general trends
Pandi-Perumal, S. R., Spence, D. W., & Sharma, V. K. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511770661.004 · Cited by 6 · see citing works
Possible mechanisms and consequences of age-related changes in the middle years of life
Carrier, J. (2009) · Cambridge University Press eBooks · doi:10.1017/cbo9780511770661.005 · Cited by 3 · see citing works
Hickie, I. B., Naismith, S. L., Ward, P. B., Little, C. L., Pearson, M., Scott, E. M., Mitchell, P. B., Wilhelm, K. A., & Parker, G. B. (2007) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.08.001 · Cited by 1 · see citing works
Self-citation
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Sorted by citations
Lyall, L. M., Wyse, C. A., Graham, N., Ferguson, A., Lyall, D. M., Cullen, B., Celis Morales, C. A., Biello, S. M., Mackay, D., Ward, J., et al. (2018) · The Lancet Psychiatry · doi:10.1016/s2215-0366(18)30139-1 · Cited by 418 · see citing works
Natural Sleep and Its Seasonal Variations in Three Pre-industrial Societies
Yetish, G., Kaplan, H., Gurven, M., Wood, B., Pontzer, H., Manger, P. R., Wilson, C., McGregor, R., & Siegel, J. M. (2015) · Current Biology · doi:10.1016/j.cub.2015.09.046 · Cited by 395 · see citing works
Candidate biomarkers in psychiatric disorders: state of the field
Abi‐Dargham, A., Moeller, S. J., Ali, F., DeLorenzo, C., Domschke, K., Horga, G., Jutla, A., Kotov, R., Paulus, M. P., Rubio, J. M., et al. (2023) · World Psychiatry · doi:10.1002/wps.21078 · Cited by 390 · see citing works
Digital Health Tools for the Passive Monitoring of Depression: A Systematic Review of Methods
de Angel, V., Lewis, S., White, K., Oetzmann, C., Leightley, D., Oprea, E., Lavelle, G., Matcham, F., Pace, A., Mohr, D. C., et al. (2021) · doi:10.1101/2021.07.19.21260786 · Cited by 227 · see citing works
Scott, J., Kallestad, H., Vedaa, O., Sivertsen, B., & Etain, B. (2021) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2021.101429 · Cited by 162 · see citing works
Rykov, Y., Thach, T.-Q., Bojic, I., Christopoulos, G., & Car, J. (2021) · JMIR mHealth and uHealth · doi:10.2196/24872 · Cited by 151 · see citing works
Sleep Disturbances in Mood Disorders
Rumble, M. E., White, K. H., & Benca, R. M. (2015) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2015.07.006 · Cited by 143 · see citing works
Variation in actigraphy-estimated rest-activity patterns by demographic factors
Mitchell, J. A., Quante, M., Godbole, S. V., James, P., Hipp, J. A., Marinac, C. R., Mariani, S., Feliciano, E. M. C., Glanz, K., Laden, F., et al. (2017) · Chronobiology International · doi:10.1080/07420528.2017.1337032 · Cited by 144 · see citing works
Ambulatory sleep-wake patterns and variability in young people with emerging mental disorders
Robillard, R., Hermens, D. F., Naismith, S. L., White, D., Rogers, N. L., Ip, T. K. C., Mullin, S. J., Alvares, G. A., Guastella, A. J., Smith, K. L., et al. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130247 · Cited by 119 · see citing works
Self-citationCircadian depression: A mood disorder phenotype
Carpenter, J. S., Crouse, J. J., Scott, E. M., Naismith, S. L., Wilson, C., Scott, J., Merikangas, K. R., & Hickie, I. B. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.045 · Cited by 114 · see citing works
Self-citationDuncan, W. C., Slonena, E., Hejazi, N. S., Brutsche, N., Yu, K. C., Park, L., Ballard, E. D., & Zarate, C. A. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.03.011 · Cited by 93 · see citing works
Melatonin has multiorgan effects
Opie, L. H., & Lecour, S. (2016) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvv037 · Cited by 91 · see citing works
Grierson, A. B., Hickie, I. B., Naismith, S. L., & Scott, J. L. (2016) · Psychological Medicine · doi:10.1017/s0033291716001392 · Cited by 79 · see citing works
Self-citationClinical correlates of chronotypes in young persons with mental disorders
Fares, S., Hermens, D. F., Naismith, S. L., White, D., Hickie, I. B., & Robillard, R. (2015) · Chronobiology International · doi:10.3109/07420528.2015.1078346 · Cited by 74 · see citing works
Self-citationIrregular sleep-wake patterns in older adults with current or remitted depression
Pye, J., Phillips, A. J. K., Cain, S. W., Montazerolghaem, M., Mowszowski, L., Duffy, S. L., Hickie, I. B., & Naismith, S. L. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.12.034 · Cited by 72 · see citing works
Self-citationMinaeva, O., Booij, S. H., Lamers, F., Antypa, N., Schoevers, R. A., Wichers, M., & Riese, H. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-00952-w · Cited by 62 · see citing works
Rumble, M. E., Dickson, D. A., McCall, W. V., Krystal, A. D., Case, D., Rosenquist, P. B., & Benca, R. M. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.11.078 · Cited by 69 · see citing works
Circadian rhythmicity in emerging mood disorders: state or trait marker?
Grierson, A. B., Hickie, I. B., Naismith, S. L., Hermens, D. F., Scott, E. M., & Scott, J. L. (2016) · International Journal of Bipolar Disorders · doi:10.1186/s40345-015-0043-z · Cited by 56 · see citing works
Self-citationCircadian preference and mental health outcomes in youth: A systematic review and meta-analysis
Cheung, F. T. W., Li, X., Hui, T. K., Chan, N. Y., Chan, N. Y., Chan, J. W. Y., & Li, S. X. (2023) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2023.101851 · Cited by 55 · see citing works
Hoyos, C. M., Gordon, C. J., Terpening, Z., Norrie, L. M., Lewis, S. J. G., Hickie, I. B., & Naismith, S. L. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02606-z · Cited by 52 · see citing works
Self-citationRobillard, R., Carpenter, J. S., Feilds, K.-L., Hermens, D. F., White, D., Naismith, S. L., Bartlett, D., Whitwell, B., Southan, J., Scott, E. M., et al. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00624 · Cited by 51 · see citing works
“A circadian phase-delay normally occurs during adolescence and young adulthood (33, 34), and our recent work suggests that delays in the sleep-wake cycle (35, 36) and endogenous melatonin rhythms (37) are especially prominent in youths with depression.”
Self-citationCharacterizing Behavioral Activity Rhythms in Older Adults Using Actigraphy
Neikrug, A. B., Chen, I. Y., Palmer, J. R., McCurry, S. M., Korff, M. V., Perlis, M. L., & Vitiello, M. V. (2020) · Sensors · doi:10.3390/s20020549 · Cited by 51 · see citing works
Smagula, S. F. (2016) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000283 · Cited by 47 · see citing works
Smagula, S. F., Boudreau, R. M., Stone, K., Reynolds, C. F., Bromberger, J. T., Ancoli-Israel, S., Dam, T.-T., Barrett-Connor, E., & Cauley, J. A. (2015) · Chronobiology International · doi:10.3109/07420528.2015.1102925 · Cited by 46 · see citing works
Recent Advances in Sleep-Wake Cycle and Biological Rhythms in Bipolar Disorder
Robillard, R., Naismith, S. L., & Hickie, I. B. (2013) · Current Psychiatry Reports · doi:10.1007/s11920-013-0402-3 · Cited by 43 · see citing works
Self-citationCarpenter, J. S., Robillard, R., Hermens, D. F., Naismith, S. L., Gordon, C. J., Scott, E. M., & Hickie, I. B. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.07.007 · Cited by 41 · see citing works
Self-citationSchick, A., Rauschenberg, C., Ader, L., Daemen, M., Wieland, L. M., Paetzold, I., Postma, M. R., Schulte‐Strathaus, J. C. C., & Reininghaus, U. (2022) · Psychological Medicine · doi:10.1017/s0033291722003336 · Cited by 32 · see citing works
Pineal volume and evening melatonin in young people with affective disorders
Carpenter, J. S., Abelmann, A. C., Hatton, S. N., Robillard, R., Hermens, D. F., Bennett, M. R., Lagopoulos, J., & Hickie, I. B. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9650-2 · Cited by 33 · see citing works
Self-citationCircadian Rhythm Sleep-Wake Disorders
Zalai, D. M., Gladanac, B., & Shapiro, C. M. (2018) · Springer eBooks · doi:10.1007/978-3-642-54836-9_11 · Cited by 32 · see citing works
Smagula, S. F., Krafty, R. T., Taylor, B. J., Martire, L. M., Schulz, R., & Hall, M. H. (2017) · Journal of Sleep Research · doi:10.1111/jsr.12549 · Cited by 31 · see citing works
Minaeva, O., Riese, H., Lamers, F., Antypa, N., Wichers, M., & Booij, S. H. (2020) · Journal of Medical Internet Research · doi:10.2196/22634 · Cited by 28 · see citing works
Song, S., Seo, Y., Hwang, S., Kim, H., & Kim, J. (2024) · JMIR mhealth and uhealth · doi:10.2196/55842 · Cited by 31 · see citing works
Mood and motor activity in euthymic bipolar disorder with sleep disturbance
Krane‐Gartiser, K., Steinan, M. K., Langsrud, K., Vestvik, V., Sand, T., Fasmer, O. B., Kallestad, H., & Morken, G. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.05.012 · Cited by 28 · see citing works
Sleep architecture in adolescents hospitalized during a suicidal crisis
Boafo, A., Armitage, R., Greenham, S. L., Tavakoli, P., Dale, A., Nixon, A., Lafrenière, A., Ray, L. B., Koninck, J. D., & Robillard, R. (2019) · Sleep Medicine · doi:10.1016/j.sleep.2018.12.018 · Cited by 27 · see citing works
Self-citationMaster, L., Nahmod, N. G., Mathew, G. M., Hale, L., Chang, A., & Buxton, O. M. (2023) · Journal of Adolescence · doi:10.1002/jad.12182 · Cited by 25 · see citing works
Merikanto, I., Partonen, T., Paunio, T., Castaneda, A. E., MARTTUNEN, M. J., & Urrila, A. S. (2017) · Chronobiology International · doi:10.1080/07420528.2017.1332072 · Cited by 25 · see citing works
Carpenter, J. S., Robillard, R., Lee, R. S. C., Hermens, D. F., Naismith, S. L., White, D., Whitwell, B. G., Scott, E. M., & Hickie, I. B. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124710 · Cited by 24 · see citing works
Self-citationLai, H., Hsu, N., Chou, P., & Chen, H. (2019) · Aging & Mental Health · doi:10.1080/13607863.2019.1582006 · Cited by 21 · see citing works
Frank, E., Benabou, M., Bentzley, B. S., Bianchi, M. T., Goldstein, T. R., Konopka, G., Maywood, E. S., Pritchett, D., Sheaves, B., & Thomas, J. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12600 · Cited by 20 · see citing works
Dück, A., Berger, C., Wunsch, K., Thome, J., Cohrs, S., Reis, O., & Haessler, F. (2015) · Journal of Neural Transmission · doi:10.1007/s00702-015-1455-8 · Cited by 19 · see citing works
Banihashemi, N., Robillard, R., Yang, J. Y. H., Carpenter, J. S., Hermens, D. F., Naismith, S. L., Terpening, Z., White, D., Scott, E. M., & Hickie, I. B. (2016) · BMC Psychiatry · doi:10.1186/s12888-016-1023-2 · Cited by 19 · see citing works
Self-citationKaur, M., Naismith, S. L., Lagopoulos, J., Hermens, D. F., Lee, R. S. C., Carpenter, J. S., Fitzgerald, P. B., Hoy, K. E., Scott, E. M., & Hickie, I. B. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.12.002 · Cited by 19 · see citing works
Self-citationRest-activity rhythms, daytime symptoms, and functional performance among people with heart failure
Jeon, S., Conley, S., & Redeker, N. S. (2020) · Chronobiology International · doi:10.1080/07420528.2020.1779280 · Cited by 18 · see citing works
Sleep disturbances and disorders in the memory clinic: Self-report, actigraphy, and polysomnography
Lam, A. K. F., Kong, S. D., D'Rozario, A. L., Ireland, C., Ahmed, R. M., Schrire, Z. M., Mowszowski, L., Michaelian, J. C., Grunstein, R. R., & Naismith, S. L. (2025) · Journal of Alzheimer s Disease · doi:10.1177/13872877251338065 · Cited by 17 · see citing works
Self-citationMaruani, J., Mauries, S., Zehani, F., Lejoyeux, M., & Geoffroy, P. A. (2024) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13739 · Cited by 15 · see citing works
Scott, E. M., Carpenter, J. S., Iorfino, F., Cross, S. P. M., Hermens, D. F., White, D., Lee, R. S. Z., Naismith, S. L., Guastella, A. J., Glozier, N., et al. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813176-3.00005-5 · Cited by 12 · see citing works
Self-citationKodama, A., Kume, Y., Tsugaruya, M., & Ishikawa, T. (2016) · Chronobiology International · doi:10.1080/07420528.2016.1196696 · Cited by 13 · see citing works
Smagula, S. F., Gasperetti, C. E., Buysse, D. J., Irwin, M. R., Krafty, R. T., Lim, S. E., Reynolds, C. F., McCall, W. V., & Harvey, A. G. (2023) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2023.11.003 · Cited by 10 · see citing works
Dell'Acqua, C., Benvenuti, S. M., Cellini, N., Brush, C. J., Ruggerone, A., & Palomba, D. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-02925-9 · Cited by 11 · see citing works
Robillard, R., Lagopoulos, J., Hermens, D. F., Naismith, S. L., Rogers, N. L., White, D., Carpenter, J. S., Kaur, M., Scott, E. M., & Hickie, I. B. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00336 · Cited by 10 · see citing works
Self-citationTavakoli, P., Lanthier, M., Porteous, M., Boafo, A., Koninck, J. D., & Robillard, R. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.920789 · Cited by 10 · see citing works
Self-citationActigraphic correlates of neuropsychiatric symptoms in adults with focal epilepsy
Abboud, M. A., Kamen, J. L., Bass, J. S., Lin, L., Gavvala, J. R., Rao, S., Smagula, S. F., & Krishnan, V. (2023) · Epilepsia · doi:10.1111/epi.17611 · Cited by 10 · see citing works
Circadian Dysregulation in Mental and Physical Health
Abbott, S. M., Malkani, R. G., & Zee, P. C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-24288-2.00039-8 · Cited by 9 · see citing works
Ghanbari, N., Nooripour, R., Shahidi, S., Zahedi, S., Heydari, M., & Vahid, N. (2024) · international journal high risk behaviors & addiction · doi:10.5812/ijhrba-140136 · Cited by 8 · see citing works
Work Habit-Related Sleep Debt; Insights From Factor Identification Analysis of Actigraphy Data
Goto, Y., Fujiwara, K., Sumi, Y., Matsuo, M., Kano, M., & Kadotani, H. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.630640 · Cited by 8 · see citing works
The Utility of Clinical Staging in Youth Mental Health Settings
Hickie, I. B., Carpenter, J. S., Iorfino, F., Scott, E. M., Cross, S. P. M., & Hermens, D. F. (2019) · Cambridge University Press eBooks · doi:10.1017/9781139839518.005 · Cited by 7 · see citing works
Self-citationCan the fluctuations of motion be used to estimate the performance of kayak paddlers?
Vadai, G., & Gingl, Z. (2016) · Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) · Cited by 5 · see citing works
Zhào, H., Li, H., Ding, Y., Li, Z., & Huang, Y. (2023) · Chronobiology International · doi:10.1080/07420528.2023.2282467 · Cited by 4 · see citing works
von Fingerhut, G., Makino, K., Katayama, O., Yamaguchi, R., Yamagiwa, D., & Shimada, H. (2025) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2025.105852 · Cited by 4 · see citing works
Halabi, R., Gonzalez‐Torres, C., MacLean, S. J., Husain, M. I., Pratap, A., Alda, M., Mulsant, B. H., & Ortiz, A. (2024) · IEEE Journal of Biomedical and Health Informatics · doi:10.1109/jbhi.2024.3394754 · Cited by 4 · see citing works
The Role of the Sleep-Wake Cycle in Adolescent Mental Illness
Wilson, C. E., Carpenter, J. S., & Hickie, I. B. (2019) · Current Sleep Medicine Reports · doi:10.1007/s40675-019-00145-y · Cited by 4 · see citing works
Self-citationCan the fluctuations of motion be used to estimate the performance of kayak paddlers?
Vadai, G., & Gingl, Z. (2016) · Journal of Statistical Mechanics Theory and Experiment · doi:10.1088/1742-5468/2016/05/054040 · Cited by 4 · see citing works
Suh, M. (2022) · Frontiers of Nursing · doi:10.2478/fon-2022-0008 · Cited by 3 · see citing works
Technological Innovations in Tropical Diseases Treatment and Therapeutics
Ogwu, M. C., & Izah, S. C. (2025) · Health information science · doi:10.1007/978-3-031-82622-1_12 · Cited by 3 · see citing works
Sleep and Biological Rhythms in Mania
Robillard, R., & Hickie, I. B. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-417188-6.00014-1 · Cited by 3 · see citing works
Self-citationFactors Associated With Sleep Disturbance Amongst Youth With Bipolar Disorder.
Barton, J. S., Mio, M., Timmins, V. H., Mitchell, R. H. B., Murray, B. J., & Goldstein, B. I. (2022) · PubMed Central · Cited by 3 · see citing works
Wilson, C. E., Crouse, J. J., Carpenter, J. S., & Hickie, I. B. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822963-7.00147-x · Cited by 3 · see citing works
Self-citationArango, C., Fegert, J. M., Picarel-Blanchot, F., Marx, U., Truffaut-Chalet, L., Pénélaud, P., Buitelaar, J. K., & the study investigators (2024) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-024-02587-4 · Cited by 2 · see citing works
Pediatric and adolescent mood disorders
Sulley, S., Ndanga, M., & Mensah, N. A. (2021) · International Journal of Pediatrics and Adolescent Medicine · doi:10.1016/j.ijpam.2021.01.002 · Cited by 2 · see citing works
Circadian Rhythm Disorders in Childhood
Miano, S. (2016) · Springer eBooks · doi:10.1007/978-3-319-28640-2_12 · Cited by 2 · see citing works
Pal, A., Sidana, I. S., & Avinash, P. (2022) · Springer eBooks · doi:10.1007/978-981-16-0123-1_19 · Cited by 2 · see citing works
Stability and Volatility of Human Rest-Activity Rhythms: Insights from Very Long Actograms (VLAs)Preprint
Adhyapak, N., Abboud, M. A., Rao, P. S. K., Kar, A., Mignot, E. J.-M., delucca, G., Smagula, S. F., & Krishnan, V. (2024) · medRxiv · doi:10.1101/2024.01.22.24301243 · Cited by 1 · see citing works
Clinical Associations of Chronotypes in Adolescents and Young Adults with Mental Disorders
Fares, S. (2016) · The Sydney eScholarship Repository (The University of Sydney)
The impact of sleep on cognition in older adults: does depression matter?
Mellor, A. (2014) · UWA Profiles and Research Repository (University of Western Australia)
Circadiane slaap-waakritmestoornissen
Gordijn, M. C. M., & Lancel, M. (2020) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-368-2524-5_7
Niittymäki, E. (2021) · Työväentutkimus Vuosikirja
Halabi, R., Gonzalez‐Torres, C., MacLean, S. J., Husain, M. I., Pratap, A., Alda, M., Mulsant, B. H., & Ortiz, A. (2023) · doi:10.36227/techrxiv.23261975
Actigraphy-derived rest-activity rhythm profiles in major depressive disorder: A cluster analysisPreprint
Poon, C.-Y., Smagula, S. F., & Ho, F. Y. (2026) · Research Square · doi:10.21203/rs.3.rs-8647960/v1
Rest-activity rhythm across the clinical spectrum of depression among adolescents
Cho, T. S. M., So, S. F., Wu, D. C. H., Chau, S. W. H., Chan, S. S., Mo, F. Y. M., Ching, E. W.-K., Wong, O. W. H., Lai, K. Y. C., Ma, S. L., et al. (2026) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2026.05.030
Sleep and Activity Patterns in Depression From Wearable Data: Unsupervised Clustering Study
Oetzmann, C., Zhang, Y., Cummins, N., Carr, E., Matcham, F., Siddi, S., Lamers, F., Leightley, D., White, K. M., Folarin, A., et al. (2026) · Journal of Medical Internet Research · doi:10.2196/86900 · Cited by 1 · see citing works
Verga, C., Bravi, B., Venturelli, E., Benatti, B. M., Maruca, S., Colombo, C., Li, P., Dallaspezia, S., & Benedetti, F. (2026) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.70107
- Authors
- Robillard, R., Naismith, S. L., Smith, K. L., Rogers, N. L., White, D., Terpening, Z., Ip, T. K. C., Hermens, D. F., Whitwell, B., Scott, E. M., & Hickie, I. B.
- Affiliations
- The University of Sydney (AU)
- Corresponding author
- Robillard, Rébecca
- Naismith, Sharon L.
- Smith, Kristie Leigh
- Rogers, Naomi L.
- White, Django
- Ip, Tony K. C.
- Hermens, Daniel F.
- Whitwell, Bradley
- Scott, Elizabeth M.
- Hickie, Ian B.
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2014-02-25
- Volume
- 9
- Issue
- 2
- Pages
- e87763
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC3934865
- OpenAlex
- W2118329301
- Cited by
- 83
- References
- 76
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 7 · 2023: 7 · 2022: 6 · 2021: 7 · 2020: 7 · 2019: 5 · 2018: 5 · 2017: 8 · 2016: 13 · 2015: 8 · 2014: 2 · 2013: 1
- FWCI
- 14.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
- Funders
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- Mental Health Commission
- Servier
- National Mental Health Commission
- Medical Research Council
- National Health and Medical Research Council (464914)
- Cilag
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- sleep-wake cycle, mood disorders, depression, age differences, circadian rhythm, acrophase, circadian rhythmicity, sleep efficiency, sleep consolidation, actigraphy, depression severity
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Aging, Body Temperature, Child, Circadian Rhythm, Depressive Disorder, Female, Humans, Male, Middle Aged, Physiological Phenomena, Sleep, Sleep Wake Disorders, Wakefulness, Mood Disorders, Young Adult, Actigraphy
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