Cited by 294Gut microbiota and healthAutism Spectrum Disorder ResearchTryptophan and brain disorders

The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.

Enteric Bacterial Metabolites Propionic and Butyric Acid Modulate Gene Expression, Including CREB-Dependent Catecholaminergic Neurotransmission, in PC12 Cells - Possible Relevance to Autism Spectrum Disorders

Open access

Nankova, Bistra B., Agarwal, Raj, MacFabe, Derrick F., La Gamma, Edmund F.·2014·PLoS ONE

DOI 10.1371/journal.pone.0103740PMC PMC4149359

Open this paper in CoChat — free account Open PDF

Abstract

Alterations in gut microbiome composition have an emerging role in health and disease including brain function and behavior. Short chain fatty acids (SCFA) like propionic (PPA), and butyric acid (BA), which are present in diet and are fermentation products of many gastrointestinal bacteria, are showing increasing importance in host health, but also may be environmental contributors in neurodevelopmental disorders including autism spectrum disorders (ASD). Further to this we have shown SCFA administration to rodents over a variety of routes (intracerebroventricular, subcutaneous, intraperitoneal) or developmental time periods can elicit behavioral, electrophysiological, neuropathological and biochemical effects consistent with findings in ASD patients. SCFA are capable of altering host gene expression, partly due to their histone deacetylase inhibitor activity. We have previously shown BA can regulate tyrosine hydroxylase (TH) mRNA levels in a PC12 cell model. Since monoamine concentration is known to be elevated in the brain and blood of ASD patients and in many ASD animal models, we hypothesized that SCFA may directly influence brain monoaminergic pathways. When PC12 cells were transiently transfected with plasmids having a luciferase reporter gene under the control of the TH promoter, PPA was found to induce reporter gene activity over a wide concentration range. CREB transcription factor(s) was necessary for the transcriptional activation of TH gene by PPA. At lower concentrations PPA also caused accumulation of TH mRNA and protein, indicative of increased cell capacity to produce catecholamines. PPA and BA induced broad alterations in gene expression including neurotransmitter systems, neuronal cell adhesion molecules, inflammation, oxidative stress, lipid metabolism and mitochondrial function, all of which have been implicated in ASD. In conclusion, our data are consistent with a molecular mechanism through which gut related environmental signals such as increased levels of SCFA's can epigenetically modulate cell function further supporting their role as environmental contributors to ASD.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1371/journal.pone.0103740

Cites

137 of 137 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
The Metabolic and Molecular Bases of Inherited Disease
Scriver, R. C. (1995) · Medical Entomology and Zoology · Cited by 12,101
Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.
Greene, L., & Tischler, A. S. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.7.2424 · Cited by 5,566
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413
Gut microbiota in health and disease
Sekirov, I., Russell, S. L., Antunes, L. C. M., & Finlay, B. B. (2010) · Physiological Reviews · doi:10.1152/physrev.00045.2009 · Cited by 4,182
The impact of the gut microbiota on human health: an integrative view
Clemente, J. C., Ursell, L. K., Parfrey, L. W., & Knight, R. (2012) · Cell · doi:10.1016/j.cell.2012.01.035 · Cited by 3,710
Microbiota Modulate Behavioral and Physiological Abnormalities Associated with Neurodevelopmental Disorders
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283
Normal gut microbiota modulates brain development and behavior
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228
The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids
Brown, A. J., Goldsworthy, S. M., Barnes, A. A., Eilert, M. M., Tcheang, L., Daniels, D., Muir, A. I., Wigglesworth, M. J., Kinghorn, I., Fraser, N. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211609200 · Cited by 2,409
Genetic Heritability and Shared Environmental Factors Among Twin Pairs With Autism
Hallmayer, J. (2011) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.76 · Cited by 1,970
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
Göttlicher, M., Minucci, S., Zhu, P., Krämer, O. H., Schimpf, A., Giavara, S., Sleeman, J. P., Coco, F. L., Nervi, C., Pelicci, P. G., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.24.6969 · Cited by 1,930
Histone Deacetylase Is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen
Phiel, C. J., Zhang, F., Huang, E. Y., Guenther, M. G., Lazar, M. A., & Klein, P. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101287200 · Cited by 1,758
Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation
Le Poul, E., Loison, C., Struyf, S., Springael, J.-Y., Lannoy, V., Decobecq, M.-E., Brezillon, S., Dupriez, V., Vassart, G., Van Damme, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301403200 · Cited by 1,651
Risperidone in Children with Autism and Serious Behavioral Problems
McCracken, J. T., McGough, J., Shah, B., Cronin, P., Hong, D., Aman, M. G., Arnold, L. E., Lindsay, R., Nash, P., Hollway, J., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013171 · Cited by 1,574
De Novo Gene Disruptions in Children on the Autistic Spectrum
Iossifov, I., Ronemus, M., Levy, D., Wang, Z., Hakker, I., Rosenbaum, J., Yamrom, B., Lee, Y.-H., Narzisi, G., Leotta, A., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.04.009 · Cited by 1,446
Mapping autism risk loci using genetic linkage and chromosomal rearrangements
The Autism Genome Project Consortium (2007) · Nature Genetics · doi:10.1038/ng1985 · Cited by 1,402
The many faces of CREB
Carlezon, W. A., Duman, R. S., & Nestler, E. J. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.06.005 · Cited by 1,382
Potential beneficial effects of butyrate in intestinal and extraintestinal diseases
Canani, R. B. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i12.1519 · Cited by 1,381
Prenatal Valproate Exposure and Risk of Autism Spectrum Disorders and Childhood Autism
Christensen, J., Grønborg, T. K., Sørensen, M. J., Schendel, D., Parner, E. T., Pedersen, L. H., & Vestergaard, M. (2013) · JAMA · doi:10.1001/jama.2013.2270 · Cited by 1,357
Histone Deacetylase Inhibitors: Inducers of Differentiation or Apoptosis of Transformed Cells
Marks, P. A., Richon, V. M., & Rifkind, R. A. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.15.1210 · Cited by 1,159
Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)
Kimura, I., Inoue, D., Maeda, T., Hara, T., Ichimura, A., Miyauchi, S., Kobayashi, M., Hirasawa, A., & Tsujimoto, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016088108 · Cited by 1,106
Gastrointestinal flora and gastrointestinal status in children with autism – comparisons to typical children and correlation with autism severity
Adams, J. B., Johansen, L. J., Powell, L. D., Quig, D., & Rubin, R. A. (2011) · BMC Gastroenterology · doi:10.1186/1471-230x-11-22 · Cited by 1,076
Mitochondrial dysfunction in autism spectrum disorders: a systematic review and meta-analysis
Rossignol, D. A., & Frye, R. E. (2011) · Molecular Psychiatry · doi:10.1038/mp.2010.136 · Cited by 940
From the gut to the peripheral tissues: the multiple effects of butyrate
Guilloteau, P., Martin, L., Eeckhaut, V., Ducatelle, R., Zabielski, R., & Immerseel, F. V. (2010) · Nutrition Research Reviews · doi:10.1017/s0954422410000247 · Cited by 842
Integration of metabolism and inflammation by lipid-activated nuclear receptors
Bensinger, S. J., & Tontonoz, P. (2008) · Nature · doi:10.1038/nature07202 · Cited by 827
Intricate Regulation of Tyrosine Hydroxylase Activity and Gene Expression
Kumer, S. C., & Vrana, K. E. (1996) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1996.67020443.x · Cited by 680
Oxidative stress in autism
Chauhan, A., & Chauhan, V. (2006) · Pathophysiology · doi:10.1016/j.pathophys.2006.05.007 · Cited by 656
Microbial genes, brain & behaviour – epigenetic regulation of the gut–brain axis
Stilling, R. M., Dinan, T. G., & Cryan, J. F. (2014) · Genes, Brain and Behavior · doi:10.1111/gbb.12109 · Cited by 637
Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon
Waldecker, M., Kautenburger, T., Daumann, H., Busch, C., & Schrenk, D. (2008) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.08.002 · Cited by 615 · cited 2×
“although it is less potent than BA [53].”
Background
Biological effects of propionic acid in humans; metabolism, potential applications and underlying mechanisms
Al-Lahham, S. H., Peppelenbosch, M. P., Roelofsen, H., Vonk, R. J., & Venema, K. (2010) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2010.07.007 · Cited by 614
What turns CREB on?
Johannessen, M., Delghandi, M. P., & Moens, U. L. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.05.001 · Cited by 586
Disruption of neurexin 1 associated with autism spectrum disorder
Kim, H.-G., Kishikawa, S., Higgins, A. W., Seong, I.-S., Donovan, D. J., Shen, Y., Lally, E., Weiss, L. A., Najm, J., Kutsche, K., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.09.011 · Cited by 578
Disorders of propionate and methylmalonate metabolism
CHALMERS, R. A., & Lawson, A. M. (1982) · Springer eBooks · doi:10.1007/978-94-009-5778-7_11 · Cited by 558
A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures
Rossignol, D. A., & Frye, R. E. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.165 · Cited by 555
Catecholaminergic systems in stress: structural and molecular genetic approaches
Kvetnansky, R., Sabban, E. L., & Palkovits, M. (2009) · Physiological Reviews · doi:10.1152/physrev.00042.2006 · Cited by 548
Neurobiological effects of intraventricular propionic acid in rats: Possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders
MACFABE, D., CAIN, D., RODRIGUEZCAPOTE, K., FRANKLIN, A., HOFFMAN, J., BOON, F., TAYLOR, A., KAVALIERS, M., & OSSENKOPP, K. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.025 · Cited by 497
Self-citation
Risperidone for the Core Symptom Domains of Autism: Results From the Study by the Autism Network of the Research Units on Pediatric Psychopharmacology
McDougle, C. J., Scahill, L. D., Aman, M. G., McCracken, J. T., Tierney, E., Davies, M., Arnold, L. E., Posey, D. J., Martin, A., GHUMAN, J. K., et al. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.6.1142 · Cited by 477
Altered profiles of intestinal microbiota and organic acids may be the origin of symptoms in irritable bowel syndrome
tana, C., umesaki, Y., imaoka, A., handa, T., kanazawa, M., & fukudo, S. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01427.x · Cited by 474
Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine
Karaki, S.-I., Mitsui, R., Hayashi, H., Kato, I., Sugiya, H., Iwanaga, T., Furness, J. B., & Kuwahara, A. (2006) · Cell and Tissue Research · doi:10.1007/s00441-005-0140-x · Cited by 473
Acylcarnitines: Role in brain
Jones, L. L., McDonald, D. A., & Borum, P. R. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.08.004 · Cited by 459
Short-chain fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders
MacFabe, D. F. (2012) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v23i0.19260 · Cited by 438
Self-citation
Altered gut microbiota and activity in a murine model of autism spectrum disorders
de Theije, C. G. M., Wopereis, H., Ramadan, M., van Eijndthoven, T., Lambert, J., Knol, J., Garssen, J., Kraneveld, A. D., & Oozeer, R. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.12.005 · Cited by 433
Elevated fecal short chain fatty acid and ammonia concentrations in children with autism spectrum disorder
Wang, L., Christophersen, C. T., Sorich, M. J., Gerber, J. P., Angley, M. T., & Conlon, M. A. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2167-7 · Cited by 412
Prenatal exposure of rats to valproic acid reproduces the cerebellar anomalies associated with autism
Ingram, J. L., Peckham, S. M., Tisdale, B., & Rodier, P. M. (2000) · Neurotoxicology and Teratology · doi:10.1016/s0892-0362(99)00083-5 · Cited by 381
Genetic reprogramming in pathways of colonic cell maturation induced by short chain fatty acids: comparison with trichostatin A, sulindac, and curcumin and implications for chemoprevention of colon cancer.
Mariadason, J. M., Corner, G. A., & Augenlicht, L. H. (2000) · PubMed · Cited by 372
Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder
MacFabe, D. F., Cain, N. E., Boon, F., Ossenkopp, K.-P., & Cain, D. P. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.10.005 · Cited by 365
Self-citation
Potentiation by specific short-chain fatty acids of differentiation and apoptosis in human colonic carcinoma cell lines.
Heerdt, B. G., Houston, M. A., & Augenlicht, L. H. (1994) · PubMed · Cited by 357
Omega-3 fatty acids suppleMentation in children with autism: A double-blind randomized, placebo-controlled pilot study
Amminger, G. P., Berger, G. E., Schäfer, M. R., Klier, C., Friedrich, M. H., & Feucht, M. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.007 · Cited by 355
What is the pathogenesis of acne?
Zouboulis, C. C., Eady, E. A., Philpott, M., Goldsmith, L. A., Orfanos, C. E., Cunliffe, W. C., & Rosenfield, R. L. (2005) · Experimental Dermatology · doi:10.1111/j.0906-6705.2005.0285a.x · Cited by 340
Deletions of NRXN1 (neurexin‐1) predispose to a wide spectrum of developmental disorders
Ching, M. S. L., Shen, Y., Tan, W., Jeste, S., Morrow, E. M., Chen, X., Mukaddes, N. M., Yoo, S.-Y., Hanson, E. M., Hundley, R. J., et al. (2010) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31063 · Cited by 306
Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299
The critical period of valproate exposure to induce autistic symptoms in Sprague–Dawley rats
Kim, K. C., Kim, P., Go, H. S., Choi, C. S., Yang, S., Cheong, J. H., Shin, C. Y., & Ko, K. H. (2010) · Toxicology Letters · doi:10.1016/j.toxlet.2010.12.018 · Cited by 292
Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host
Ganapathy, V., Thangaraju, M., Prasad, P. D., Martin, P. M., & Singh, N. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.08.006 · Cited by 290
Pathway Mapping Tools for Analysis of High Content Data
Ekins, S., Nikolsky, Y., Bugrim, A. E., Kirillov, E., & Nikolskaya, T. (2006) · Humana Press eBooks · doi:10.1385/1-59745-217-3:319 · Cited by 266
Plasma fatty acid levels in autistic children
Vancassel, S., Durand, G., Barthélémy, C., Lejeune, B., Martineau, J., Guilloteau, D., Andres, C. R., & Chalon, S. (2001) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0281 · Cited by 265
Transmitter, ion channel and receptor properties of pheochromocytoma (PC12) cells: a model for neurotoxicological studies.
Shafer, T. J., & Atchison, W. D. (1991) · PubMed · Cited by 252
Prevalence of SHANK3 variants in patients with different subtypes of autism spectrum disorders
Boccuto, L., Lauri, M., Sarasua, S. M., Skinner, C. D., Buccella, D., Dwivedi, A., Orteschi, D., Collins, J. S., Zollino, M., Visconti, P., et al. (2013) · European Journal of Human Genetics · doi:10.1038/ejhg.2012.175 · Cited by 240
Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder
Frye, R. E., Melnyk, S., & MacFabe, D. F. (2013) · Translational Psychiatry · doi:10.1038/tp.2012.143 · Cited by 239
Self-citation
The Interaction of Histone Deacetylase Inhibitors and DNA Methyltransferase Inhibitors in the Treatment of Human Cancer Cells
Zhu, W., & Otterson, G. A. (2003) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1568011033482440 · Cited by 226
Cellular and mitochondrial glutathione redox imbalance in lymphoblastoid cells derived from children with autism
James, S. J., Rose, S., Melnyk, S., Jernigan, S., Blossom, S. J., Pavliv, O., & Gaylor, D. W. (2009) · The FASEB Journal · doi:10.1096/fj.08-128926 · Cited by 223
Pathways underlying the gut-to-brain connection in autism spectrum disorders as future targets for disease management
de Theije, C. G. M., Wu, J., da Silva, S. L., Kamphuis, P. J. G. H., Garssen, J., Korte, S. M., & Kraneveld, A. D. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.07.013 · Cited by 212
Etiology of autistic features: the persisting neurotoxic effects of propionic acid
El-Ansary, A. K., Bacha, A. B., & Kotb, M. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-74 · Cited by 209
Clinical spectrum of succinic semialdehyde dehydrogenase deficiency
Pearl, P. L., Gibson, K. M., Acosta, M. T., Vezina, L. G., Theodore, W. H., Rogawski, M. A., Novotny, E. J., Gropman, A. L., Conry, J. A., Berry, G. T., et al. (2003) · Neurology · doi:10.1212/01.wnl.0000059549.70717.80 · Cited by 203
Increased Monoamine Concentration in the Brain and Blood of Fetal Thalidomide- and Valproic Acid-Exposed Rat: Putative Animal Models for Autism
Narita, N., Kato, M., Tazoe, M., Miyazaki, K., Narita, M., & Okado, N. (2002) · Pediatric Research · doi:10.1203/00006450-200210000-00018 · Cited by 203
The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: Further development of a rodent model of autism spectrum disorders
Thomas, R. H., Meeking, M. M., Mepham, J. R., Tichenoff, L., Possmayer, F., Liu, S., & MacFabe, D. F. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-153 · Cited by 200
Self-citation
Essential fatty acids and phospholipase A2 in autistic spectrum disorders
Bell, J. G., Mackinlay, E. E., Dick, J. R., MacDonald, D. J., Boyle, R. M., & Glen, A. C. A. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2004.03.008 · Cited by 199
Short chain fatty acids dilate isolated human colonic resistance arteries.
Mortensen, F. V., Nielsen, H. K., Mulvany, M. J., & Hessov, I. (1990) · Gut · doi:10.1136/gut.31.12.1391 · Cited by 197
Brain Region-Specific Glutathione Redox Imbalance in Autism
Chauhan, A., AUDHYA, T. K., & Chauhan, V. P. S. (2012) · Neurochemical Research · doi:10.1007/s11064-012-0775-4 · Cited by 196
Evaluation of copy number variations reveals novel candidate genes in autism spectrum disorder-associated pathways
Griswold, A. J., Ma, D., Cukier, H. N., Nations, L. D., Schmidt, M. A., Chung, R.-H., Jaworski, J. M., Salyakina, D., Konidari, I., Whitehead, P. L., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds164 · Cited by 191
Increased Norepinephrine Levels and Decreased Dopamine-β-Hydroxylase Activity in Primary Autism
Lake, C. R. (1977) · Archives of General Psychiatry · doi:10.1001/archpsyc.1977.01770170063005 · Cited by 182
AutismKB: an evidence-based knowledgebase of autism genetics
Xu, L.-M., Li, J.-R., Huang, Y., Zhao, M., Tang, X., & Wei, L. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr1145 · Cited by 179
Short-chain fatty acid-initiated cell cycle arrest and apoptosis of colonic epithelial cells is linked to mitochondrial function.
Heerdt, B. G., Houston, M. A., & Augenlicht, L. H. (1997) · PubMed · Cited by 179
Short-Chain Fatty Acid Inhibitors of Histone Deacetylases: Promising Anticancer Therapeutics?
Chen, J. M., Faller, D. V., & Spanjaard, R. A. (2003) · Current Cancer Drug Targets · doi:10.2174/1568009033481994 · Cited by 174
Genes Controlling Affiliative Behavior as Candidate Genes for Autism
Yrigollen, C. M., Han, S. S., Kochetkova, A., Babitz, T., Chang, J. T., Volkmar, F. R., Leckman, J. F., & Grigorenko, E. L. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.11.015 · Cited by 172
Remodeling Chromatin and Stress Resistance in the Central Nervous System: Histone Deacetylase Inhibitors as Novel and Broadly Effective Neuroprotective Agents
Langley, B. C., Gensert, J. M., Beal, M. F., & Ratan, R. R. (2005) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007053005091 · Cited by 169
Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long–Evans rat: Further development of a rodent model of autism
Shultz, S. R., MacFabe, D. F., Martin, S. P., Jackson, J., Taylor, R., Boon, F. H., Ossenkopp, K., & Cain, D. P. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.12.023 · Cited by 159
Self-citation
Early medical history of children with autism spectrum disorders
NIEHUS, R., & LORD, C. (2006) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/00004703-200604002-00010 · Cited by 152
Short chain fatty acids regulate tyrosine hydroxylase gene expression through a cAMP-dependent signaling pathway
DeCastro, M., Nankova, B. B., Shah, P., Patel, P., Mally, P. V., Mishra, R., & La Gamma, E. F. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.09.002 · Cited by 149
Self-citation
The roles of TTP and BRF proteins in regulated mRNA decay
Sanduja, S., Blanco, F. F., & Dixon, D. A. (2011) · WIREs RNA · doi:10.1002/wrna.28 · Cited by 144
Review Article: Carnitine, Valproate, and Toxicity
Coulter, D. L. (1991) · Journal of Child Neurology · doi:10.1177/088307389100600102 · Cited by 142
Short-Chain Carboxylic-Acid-Stimulated, PMN-Mediated Gingival Inflammation
Niederman, R., Zhang, J., & Kashket, S. (1997) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411970080030301 · Cited by 142
Molecular analysis of nicotinic receptor expression in autism
Martin-Ruiz, C. M., Lee, M., Perry, R. H., Baumann, M., Court, J. A., & Perry, E. K. (2004) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.01.003 · Cited by 141
Maternal behavior and developmental psychopathology
Leckman, J. F., & Herman, A. E. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01277-x · Cited by 139
Pre- and Neonatal Exposure to Lipopolysaccharide or the Enteric Metabolite, Propionic Acid, Alters Development and Behavior in Adolescent Rats in a Sexually Dimorphic Manner
Foley, K. A., Ossenkopp, K., Kavaliers, M., & MacFabe, D. F. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087072 · Cited by 135
Self-citation
Autism: Metabolism, Mitochondria, and the Microbiome
Macfabe, D. (2013) · Global Advances in Health and Medicine · doi:10.7453/gahmj.2013.089 · Cited by 131
Self-citation
Immunogold Cytochemistry Identifies Specialized Membrane Domains for Monocarboxylate Transport in the Central Nervous System
Bergersen, L. H., Rafiki, A., & Ottersen, O. P. (2002) · Neurochemical Research · doi:10.1023/a:1014806723147 · Cited by 129
Role of polyunsaturated fatty acids in the management of Egyptian children with autism
Meguid, N. A., Atta, H. M., Gouda, A. S., & Khalil, R. O. (2008) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2008.05.013 · Cited by 128
Dietary Inhibitors of Histone Deacetylases in Intestinal Immunity and Homeostasis
Schilderink, R., Verseijden, C., & de Jonge, W. J. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00226 · Cited by 121
Altered brain phospholipid and acylcarnitine profiles in propionic acid infused rodents: further development of a potential model of autism spectrum disorders
Thomas, R., Foley, K. A., Mepham, J. R., Tichenoff, L. J., Possmayer, F., & MacFabe, D. F. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06614.x · Cited by 121
Self-citation
Sexually dimorphic effects of prenatal exposure to propionic acid and lipopolysaccharide on social behavior in neonatal, adolescent, and adult rats: Implications for autism spectrum disorders
Foley, K. A., MacFabe, D. F., Vaz, A., Ossenkopp, K., & Kavaliers, M. (2014) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2014.04.001 · Cited by 116
Self-citation
The Neurobiology of Lipid Metabolism in Autism Spectrum Disorders
Tamiji, J., & Crawford, D. A. (2010) · Neurosignals · doi:10.1159/000323189 · Cited by 116
State of the art; microbiology in health and disease. Intestinal bacterial flora in autism
Finegold, S. M. (2011) · Anaerobe · doi:10.1016/j.anaerobe.2011.03.007 · Cited by 116
Biological networks and analysis of experimental data in drug discovery
Nikolsky, Y., Nikolskaya, T., & Bugrim, A. E. (2005) · Drug Discovery Today · doi:10.1016/s1359-6446(05)03420-3 · Cited by 114
Neural and non‐neural mediation of propionate‐induced contractile responses in the rat distal colon
Mitsui, R., Ono, S., Karaki, S.-I., & Kuwahara, A. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00669.x · Cited by 105
Clinical trials of fatty acid treatment in ADHD, dyslexia, dyspraxia and the autistic spectrum
Richardson, A. J. (2004) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2003.12.020 · Cited by 104
Red blood cell fatty acid compositions in a patient with autistic spectrum disorder: a characteristic abnormality in neurodevelopmental disorders?
Bell, J. G., SARGENT, J. R., Tocher, D. R., & Dick, J. R. (2000) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2000.0186 · Cited by 103
Short‐chain fatty acid receptor GPR41‐mediated activation of sympathetic neurons involves synapsin 2b phosphorylation
Inoue, D., Kimura, I., Wakabayashi, M., Tsumoto, H., Ozawa, K., Hara, T., Takei, Y., Hirasawa, A., Ishihama, Y., & Tsujimoto, G. (2012) · FEBS Letters · doi:10.1016/j.febslet.2012.04.021 · Cited by 99
Plasma fatty acid profiles in autism: A case-control study
Wiest, M. M., German, J. B., Harvey, D. J., Watkins, S. M., & Hertz‐Picciotto, I. (2009) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2009.01.007 · Cited by 97
Serotonin Hypothesis of Autism: Implications for Selective Serotonin Reuptake Inhibitor Use during Pregnancy
Harrington, R. A., Lee, L., Crum, R. M., Zimmerman, A. W., & Hertz‐Picciotto, I. (2013) · Autism Research · doi:10.1002/aur.1288 · Cited by 93
Genetically determined low maternal serum dopamine ?-hydroxylase levels and the etiology of autism spectrum disorders
Robinson, P. D., Schutz, C. K., Macciardi, F. M., White, B. N., & Holden, J. J. A. (2001) · American Journal of Medical Genetics · doi:10.1002/ajmg.1187 · Cited by 90
Low Serum Biotinidase Activity in Children with Valproic Acid Monotherapy
Schulpis, K. H., Karikas, G. A., Tjamouranis, J., Regoutas, S., & Tsakiris, S. (2001) · Epilepsia · doi:10.1046/j.1528-1157.2001.47000.x · Cited by 86
Dysregulation of fragile × mental retardation protein and metabotropic glutamate receptor 5 in superior frontal cortex of individuals with autism: a postmortem brain study
Fatemi, S. H., & Folsom, T. D. (2011) · Molecular Autism · doi:10.1186/2040-2392-2-6 · Cited by 84
Propionic Acidemia: A Neuropathology Case Report and Review of Prior Cases
Feliz, B., Witt, D. R., & Harris, B. T. (2003) · Archives of Pathology & Laboratory Medicine · doi:10.5858/2003-127-e325-paancr · Cited by 84
Autism: The role of cholesterol in treatment
Aneja, A., & Tierney, E. (2008) · International Review of Psychiatry · doi:10.1080/09540260801889062 · Cited by 82
Mitochondrial membrane potential (delta psi(mt)) in the coordination of p53-independent proliferation and apoptosis pathways in human colonic carcinoma cells.
Heerdt, B. G., Houston, M. A., Anthony, G. M., & Augenlicht, L. H. (1998) · PubMed · Cited by 76
Gastrointestinal Microbiota and Metabolite Biomarkers in Children With Autism Spectrum Disorders
Wang, L., Conlon, M. A., Christophersen, C. T., Sorich, M. J., & Angley, M. T. (2014) · Biomarkers in Medicine · doi:10.2217/bmm.14.12 · Cited by 72
Short chain fatty acids induce TH gene expression via ERK-dependent phosphorylation of CREB protein
Shah, P. G., Nankova, B. B., Parab, S., & Gamma, E. F. L. (2006) · Brain Research · doi:10.1016/j.brainres.2006.05.097 · Cited by 71
Self-citation
Metabolic effects of sapropterin treatment in autism spectrum disorder: a preliminary study
Frye, R. E., DeLaTorre, R., Taylor, H., Slattery, J. M., Melnyk, S., Chowdhury, N., & James, S. J. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.14 · Cited by 70
Propionate increases neuronal histone acetylation, but is metabolized oxidatively by glia. Relevance for propionic acidemia
Nguyen, N. H. T., Morland, C., González, S. V., Rise, F., Storm‐Mathisen, J., Gundersen, V., & Hassel, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04397.x · Cited by 67
Systemic treatment with the enteric bacterial fermentation product, propionic acid, produces both conditioned taste avoidance and conditioned place avoidance in rats
Ossenkopp, K., Foley, K. A., Gibson, J., Fudge, M. A., Kavaliers, M., Cain, D. P., & MacFabe, D. F. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.10.045 · Cited by 65
Self-citation
Characterization of alpha-keto acid transport across blood-brain barrier in rats
Conn, A. R., Fell, D. I., & Steele, R. D. (1983) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1983.245.3.e253 · Cited by 65
Effect of Chemically Induced Propionic Acidemia on Neurobehavioral Development of Rats
Brusque, A. M., Mello, C. F., BUCHANAN, D., TERRACCIANO, S., Rocha, M., Vargas, C. R., Wannmacher, C. M. D., & Wajner, M. (1999) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(99)00127-6 · Cited by 62
Current concepts in organic acidurias: understanding intra‐ and extracerebral disease manifestation
Kölker, S., Burgard, P., Sauer, S. W., & Okun, J. G. (2013) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-013-9600-8 · Cited by 62
Ascorbic acid prevents cognitive deficits caused by chronic administration of propionic acid to rats in the water maze
Pettenuzzo, L. F. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00856-0 · Cited by 62
Epigenetic, transcriptional and posttranscriptional regulation of the tyrosine hydroxylase gene
Lenartowski, R., & Goc, A. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2011.07.006 · Cited by 58
Acute prenatal exposure to a moderate dose of valproic acid increases social behavior and alters gene expression in rats
Cohen, O. S., Varlinskaya, E. I., Wilson, C., Glatt, S. J., & Mooney, S. M. (2013) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2013.09.002 · Cited by 57
Increased Monoamine Concentration in the Brain and Blood of Fetal Thalidomide- and Valproic Acid-Exposed Rat: Putative Animal Models for Autism
NARITA, N. (2002) · Pediatric Research · doi:10.1203/01.pdr.0000028406.01104.76 · Cited by 57
Unexpectedly high prevalence of the mild form of propionic acidemia in Japan: presence of a common mutation and possible clinical implications
Yorifuji, T., Kawai, M., Muroi, J., Mamada, M., Kurokawa, K., Shigematsu, Y., Hirano, S., Sakura, N., Yoshida, I., Kuhara, T., et al. (2002) · Human Genetics · doi:10.1007/s00439-002-0761-z · Cited by 56
Swim stress exaggerates the hyperactive mesocortical dopamine system in a rodent model of autism
Nakasato, A., Nakatani, Y., Seki, Y., Tsujino, N., Umino, M., & Arita, H. (2007) · Brain Research · doi:10.1016/j.brainres.2007.11.043 · Cited by 54
Valproic acid regulates catecholaminergic pathways by concentration-dependent threshold effects on TH mRNA synthesis and degradation
D’Souza, A., Onem, E., Patel, P., Gamma, E. F. L., & Nankova, B. B. (2008) · Brain Research · doi:10.1016/j.brainres.2008.09.088 · Cited by 49
Self-citation
Control of tyrosine hydroxylase gene expression in chromaffin and PC12 cells
Sabban, E. L. (1997) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.1996.0129 · Cited by 46
Effect of short-chain fatty acids on contraction of smooth muscle in the canine colon
McManus, C. M., Michel, K. E., Simon, D. M., & Washabau, R. J. (2002) · American Journal of Veterinary Research · doi:10.2460/ajvr.2002.63.295 · Cited by 46
Interaction of cyclic AMP and cell-cell contact in the control of tyrosine hydroxylase RNA
Fader, D., & Lewis, E. J. (1990) · Molecular Brain Research · doi:10.1016/0169-328x(90)90005-x · Cited by 44
Nicotinic cholinergic antagonists: A novel approach for the treatment of autism
Lippiello, P. M. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2005.11.015 · Cited by 43
Stereospecific Regulation of Tyrosine Hydroxylase and Proenkephalin Genes by Short-Chain Fatty Acids in Rat PC12 Cells
Mally, P., Mishra, R., Gandhi, S., DeCastro, M., Nankova, B. B., & LaGamma, E. F. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000119365.21770.45 · Cited by 40
Self-citation
Butyrate, a gut-derived environmental signal, regulates tyrosine hydroxylase gene expression via a novel promoter element
Patel, P., Nankova, B. B., & LaGamma, E. F. (2005) · Developmental Brain Research · doi:10.1016/j.devbrainres.2005.08.005 · Cited by 40
Self-citation
Short‐chain fatty acids present in the ileum inhibit fasting gastrointestinal motility in conscious pigs
CUCHE, & MALBERT (1999) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.1999.00149.x · Cited by 37
Modifier effects in autism at the MAO‐A and DBH loci
Jones, M. B., Palmour, R. M., Zwaigenbaum, L., & Szatmári, P. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.20172 · Cited by 37
Differential regulation of the tyrosine hydroxylase and enkephalin neuropeptide transmitter genes in rat PC12 cells by short chain fatty acids: Concentration-dependent effects on transcription and RNA stability
Parab, S., Nankova, B. B., & Gamma, E. F. L. (2006) · Brain Research · doi:10.1016/j.brainres.2006.11.013 · Cited by 36
Self-citation
Propionate Modulates Spontaneous Contractions via Enteric Nerves and Prostaglandin Release in the Rat Distal Colon
Mitsui, R., Ono, S., Karaki, S.-I., & Kuwahara, A. (2005) · The Japanese Journal of Physiology · doi:10.2170/jjphysiol.rp000205 · Cited by 29
Adrenergic differentiation potential in PC12 cells: influence of sodium butyrate and dexamethasone
Ebert, S. N., Lindley, S. E., Bengoechea, T. G., Bain, D. L., & Wong, D. L. (1997) · Molecular Brain Research · doi:10.1016/s0169-328x(97)00032-6 · Cited by 28
Selected biomarkers as predictive tools in testing efficacy of melatonin and coenzyme Q on propionic acid - induced neurotoxicity in rodent model of autism
Al-Ghamdi, M., Al-Ayadhi, L., & El-Ansary, A. (2014) · BMC Neuroscience · doi:10.1186/1471-2202-15-34 · Cited by 25
Animal Models of Self-Injurious Behaviour: An Overview
Devine, D. P. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-458-2_4 · Cited by 24
Vascular Endothelial Growth Factor: Not Only for Vessels Anymore
Abman, S. H. (2003) · Pediatric Research · doi:10.1203/00006450-200301000-00001 · Cited by 23
Nicotinic Induction of Preproenkephalin and Tyrosine Hydroxylase Gene Expression in Butyrate-Differentiated Rat PC12 Cells: A Model for Adaptation to Gut-Derived Environmental Signals
Nankova, B. B., Chua, J., Mishra, R., Kobasiuk, C. D., & Gamma, E. F. L. (2003) · Pediatric Research · doi:10.1203/00006450-200301000-00019 · Cited by 22
Self-citation
Sodium butyrate modifies the stabilizing complexes of tyrosine hydroxylase mRNA
Arányi, T., Sarkis, C., Berrard, S., Sardin, K., Siron, V., Khalfallah, O., & Mallet, J. J. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.05.025 · Cited by 15
Role of Ca2+ in induction of neurotransmitter-related gene expression by butyrate
Zia, M., Nankova, B. B., Krishnan, K., Gueorguiev, V. D., Frenz, C. M., Sabban, E. L., & Gamma, E. F. L. (2004) · Neuroreport · doi:10.1097/00001756-200405190-00019 · Cited by 6
Self-citation

Flagged first, then by citations

Sorted by citations

The role of short-chain fatty acids in microbiota–gut–brain communication
Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0157-3 · Cited by 3,357
The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
Silva, Y. P., Bernardi, A., & Frozza, R. L. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00025 · Cited by 3,043
“In particular, these SCFAs regulate the expression levels of tryptophan 5-hydroxylase 1, the enzyme involved in synthesis of serotonin, and tyrosine hydroxylase, which is involved in a rate-limiting step in the biosynthesis of dopamine, noradrenaline and adrenaline; therefore, producing an effect on brain neurochemist…”
Background
Prebiotics: Definition, Types, Sources, Mechanisms, and Clinical Applications
Davani-Davari, D., Negahdaripour, M., Karimzadeh, I., Seifan, M., Mohkam, M., Masoumi, S. J., Berenjian, A., & Ghasemi, Y. (2019) · Foods · doi:10.3390/foods8030092 · Cited by 1,848
Short-Chain Fatty-Acid-Producing Bacteria: Key Components of the Human Gut Microbiota
Fusco, W. G., Bernabeu, M., Cintoni, M., Porcari, S., Rinninella, E., Kaitsas, F., Lener, E., Mele, M. C., Gasbarrini, A., Collado, M. C., et al. (2023) · Nutrients · doi:10.3390/nu15092211 · Cited by 1,397
Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Sharon, G., Cruz, N. J., Kang, D.-W., Gandal, M. J., Wang, B., Kim, Y.-M., Zink, E. M., Casey, C. P., Taylor, B. C., Lane, C. J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.004 · Cited by 1,182

See all 294

Authors: Nankova, B. B., Agarwal, R., MacFabe, D. F., & La Gamma, E. F.
Affiliations: New York Medical College (US)
Western University (CA)
Corresponding author: Nankova, Bistra B.
ORCID: Nankova, Bistra B.
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2014-08-29
Volume: 9
Issue: 8
Pages: e103740
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0103740
PMC: PMC4149359
OpenAlex: W2028901643
Cited by: 294
References: 136
Citations by year: 2026: 24 · 2025: 26 · 2024: 30 · 2023: 29 · 2022: 43 · 2021: 34 · 2020: 37 · 2019: 19 · 2018: 21 · 2017: 8 · 2016: 14 · 2015: 8 · 2014: 1
FWCI: 4.23
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Touro Scholar (Touro College) (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Figshare (submittedVersion, cc-by)
Funders: Autism Research Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: propionic acid, butyrate, short-chain fatty acids, gut microbiota, autism spectrum disorder, catecholaminergic neurotransmission, tyrosine hydroxylase, CREB transcription factor, PC12 cells, histone deacetylase inhibition, epigenetic regulation, monoamines, neurodevelopmental disorders, gut-brain axis
MeSH terms: Animals, Child Development Disorders, Pervasive, Enterobacteriaceae, Gene Expression Regulation, Synaptic Transmission, Propionates, Tyrosine 3-Monooxygenase, Transcriptional Activation, PC12 Cells, Cyclic AMP Response Element-Binding Protein, Butyric Acid, Rats, Gene Regulatory Networks, Host-Pathogen Interactions

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Enteric Bacterial Metabolites Propionic and Butyric Acid Modulate Gene Expression, Including CREB-Dependent Catecholaminergic Neurotransmission, in PC12 Cells - Possible Relevance to Autism Spectrum Disorders

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks