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Hormonal Induction and Roles of Disabled-2 in Lactation and Involution

Tao, Wensi, Moore, Robert, Smith, Elizabeth R., Xu, Xiang-Xi·2014·PLoS ONE
DOI 10.1371/journal.pone.0110737PMC PMC4216001
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Crossref · 10.1371/journal.pone.0110737

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  • Dab2 expression is absent or very low in virgin mammary epithelial cells, but is greatly induced in mammary glands during pregnancy and lactation.

    “its expression was found to be absent or very low in virgin mammary epithelial cells, but is greatly induced in mammary glands during pregnancy and lactation (Tao et al., 2014).”

    From Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice (2016) · cites this paper as Tao et al., 2014

    The Results section, “Induction of Dab2 expression in mammary glands during pregnancy and lactation,” reports that Dab2 was essentially undetectable in virgin mammary epithelial cells and was massively induced during lactation. It reports only a low level during pregnancy, so “greatly induced” overstates the pregnancy finding. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Despite rigorous investigation, phenotypes such as cell growth and survival, nutrient uptake, milk production, and secretion were not found in mammary glands of Dab2 null mice; only subtle differences were observed.

    “However, despite rigorous investigation, these phenotypes were not found, and only subtle differences were observed between control and Dab2-deficient mice (Tao et al., 2014).”

    From Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice (2016) · cites this paper as Tao et al., 2014

    The Discussion says that only subtle differences in mammary functions were observed, and the Results report minimal effects on milk production and nursing. But the Results section on delayed mammary involution reports delayed cell clearance and differences in apoptosis and survival markers, so the claim that cell-survival phenotypes were not found is too broad. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • Dab2 null mice show delayed mammary gland involution.

    “Mammary glands/epithelia | Delayed involution”

    From Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice (2016) · cites this paper as Tao et al., 2014

  • The lack of more noticeable differences in the mammary glands of Dab2 null mice may be due to the compensation of other endocytic adaptors, such as Numb and Arh.

    “The lack of more noticeable differences in the mammary glands of Dab2 null mice may be due to the compensation of other endocytic adaptors, such as Numb and Arh.”

    From Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice (2016) · cites this paper as Tao et al., 2014

  • Numb and Arh protein levels are elevated in Dab2-deficient mammary epithelial cells.

    “Indeed, Numb and Arh protein levels are elevated in Dab2-deficient mammary epithelial cells (Tao et al., 2014).”

    From Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice (2016) · cites this paper as Tao et al., 2014

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Metadata

Authors
Tao, W., Moore, R., Smith, E. R., & Xu, X.-X.
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2014-10-31
Volume
9
Issue
10
Pages
e110737
ISSN
1932-6203
DOI
10.1371/journal.pone.0110737
PMC
PMC4216001
Cited by
11
References
2
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

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