Cited by 169Physical Activity and HealthDiabetes, Cardiovascular Risks, and LipoproteinsErgonomics and Musculoskeletal Disorders

Associations of sitting accumulation patterns with cardio-metabolic risk biomarkers in Australian adults

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Bellettiere, John, Winkler, Elisabeth A. H., Chastin, Sebastien F. M., Kerr, Jacqueline, Owen, Neville, Dunstan, David W., Healy, Genevieve N.·2017·PLOS ONE

Abstract

BACKGROUND: High amounts of time spent sitting can increase cardiovascular disease risk and are deleteriously associated cardio-metabolic risk biomarkers. Though evidence suggests that accruing sitting time in prolonged periods may convey additional risk, verification using high-quality measures is needed. We examined this issue in adults from the Australian Diabetes, Obesity and Lifestyle Study, using accurate measures of sitting accumulation. METHODS: In 2011/12, 739 adults aged 36 to 89 years (mean±SD 58±10 years) wore activPAL3™ monitors (which provide accurate objective measures of sitting); 678 provided ≥4 valid days of monitor data and complete cardio-metabolic biomarker and confounder data. Multivariable linear regression models examined associations of sitting time, sitting time accrued in ≥30 minute bouts (prolonged sitting time), and three measures of sitting accumulation patterns with cardio-metabolic risk markers: body mass index (BMI), waist circumference, blood pressure, high- and low- density lipoprotein (HDL and LDL) cholesterol, triglycerides, glycated haemoglobin (HbA1c), fasting plasma glucose (FPG) and 2-hour post-load glucose (PLG). Interactions tests examined whether associations of sitting time with biomarkers varied by usual sitting bout duration. RESULTS: Adjusted for potential confounders, greater amounts of sitting time and prolonged sitting time were significantly (p<0.05) deleteriously associated with BMI, waist circumference, HDL cholesterol, and triglycerides. Total sitting time was also significantly associated with higher PLG. Sitting accumulation patterns of frequently interrupted sitting (compared to patterns with relatively more prolonged sitting) were significantly beneficially associated with BMI, waist circumference, HDL cholesterol, triglycerides, PLG, and with FPG. Effect sizes were typically larger for accumulation patterns than for sitting time. Significant interactions (p<0.05) showed that associations of sitting time with HDL, triglycerides and PLG became more deleterious the longer at a time sitting was usually accumulated. CONCLUSIONS: Adding to previous evidence reliant on low-quality measures, our study showed that accumulating sitting in patterns where sitting was most frequently interrupted had significant beneficial associations with several cardio-metabolic biomarkers and that sitting for prolonged periods at a time may exacerbate some of the effects of sitting time. The findings support sedentary behavior guidelines that promote reducing and regularly interrupting sitting.

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  1. [39]Grant PM, Ryan CG, Tigbe WW, Granat MH. The validation of a novel activity monitor in the measurement of posture and motion during everyday activities. Br J Sports Med. 2006; 40: 992– 997. doi: 10.1136/bjsm.2006.030262 16980531 PMC2577473 · DOI
  2. [42]Chastin SF, Winkler EA, Eakin EG, Gardiner PA, Dunstan DW, Owen N, et al Sensitivity to change of objectively-derived measures of sedentary behavior: supplementary material. In: Measurement in Physical Education and Exercise Science [Internet]. 2015 [cited 26 Jan 2016]. http://www.tandfonline.com/doi/suppl/10.1080/1091367X.2015.1050592/suppl_file/hmpe_a_1050592_sm0678.docx · DOI

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Authors
Bellettiere, J., Winkler, E. A. H., Chastin, S. F. M., Kerr, J., Owen, N., Dunstan, D. W., & Healy, G. N.
Affiliations
  • San Diego State University (US)
  • The University of Queensland (AU)
  • Glasgow Caledonian University (GB)
  • University of California San Diego (US)
  • Baker Heart and Diabetes Institute (AU)
Corresponding author
  • Bellettiere, John
  • Winkler, Elisabeth A. H.
  • Chastin, Sebastien F. M.
  • Kerr, Jacqueline
  • Owen, Neville
  • Dunstan, David W.
  • Healy, Genevieve N.
Venue
PLOS ONE
Published
2017-06-29
Volume
12
Issue
6
Pages
e0180119
ISSN
1932-6203 (ISSN-L)
OpenAlex
W2729779756
Cited by
169
References
45
Citations by year
2026: 2 · 2025: 11 · 2024: 14 · 2023: 13 · 2022: 19 · 2021: 38 · 2020: 22 · 2019: 29 · 2018: 18 · 2017: 3
FWCI
14.57
Type
journal article
Language
en
Open access
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • UniSA Research Outputs Repository (University of South Australia) (acceptedVersion, other-oa)
  • ResearchOnline (Glasgow Caledonian University) (acceptedVersion, cc-by)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
  • Minerva Access (University of Melbourne) (submittedVersion, cc-by)
  • Research Bank (Australian Catholic University) (submittedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Own your potential (DEAKIN) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
  • Swinburne figshare (Swinburne University of Technology) (submittedVersion, cc-by)
  • Swinburne figshare (Swinburne University of Technology) (cc-by)
Funders
National Health and Medical Research Council (566940, 1000986, 1003960, 1078360, 108029, 233200)
Topics
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Social Sciences › Psychology › Social Psychology › Ergonomics and Musculoskeletal Disorders
Keywords
sedentary behavior, prolonged sitting, body mass index, waist circumference, HDL cholesterol, triglycerides, HbA1c, post-load glucose, blood pressure, Australian adults
MeSH terms
Adult, Aged, Aged, 80 and over, Australia, Cardiovascular Diseases, Female, Humans, Male, Middle Aged, Posture, Biomarkers, Young Adult, Sedentary Behavior

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