Interplay between obesity and associated metabolic disorders: New insights into the gut microbiota
Abstract
Obesity and associated metabolic disorders are worldwide epidemic. The literature provides new evidence that gut microbiota dysbiosis (at the phyla, genus, or species level) affects host metabolism and energy storage. Here we discuss new findings that may explain how gut microbiota can be involved in the development or in the control of obesity and associated low-grade inflammation. New powerful molecular biology methods and the use of gnotobiotic animal allowed to analyze the molecular link between gut bacteria and the host. Moreover, even if more studies are needed to unravel how changing gut microbiota impacts on the development of obesity and related metabolic alterations, probiotic and prebiotic approach appear as potential interesting treatments to reverse host metabolic alterations linked to gut microbiota dysbiosis.
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In obese rodents, antibiotics and prebiotics were able to restore gut barrier integrity and metabolic functions, providing evidence for the gut barrier as a mediator of microbiota-induced systemic inflammation.
“In obese rodents, antibiotics and prebiotics were able to restore gut barrier integrity and metabolic functions, providing evidence for the gut barrier as a mediator of microbiota-induced systemic inflammation [98,99].”
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- Authors
- Cani, P. D., & Delzenne, N. M.
- Affiliations
- UCLouvain (BE)
- Corresponding author
- Cani, Patrice D
- Venue
- Current Opinion in Pharmacology
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 9
- Issue
- 6
- Pages
- 737-743
- ISSN
- 1471-4892 (ISSN-L)
- OpenAlex
- W1982319117
- Cited by
- 377
- References
- 47
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 11 · 2023: 16 · 2022: 19 · 2021: 16 · 2020: 20 · 2019: 30 · 2018: 20 · 2017: 22 · 2016: 19 · 2015: 32 · 2014: 35 · 2013: 31 · 2012: 30
- FWCI
- 11.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- DIAL (Catholic University of Leuven) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- obesity, gut microbiota, dysbiosis, metabolic disorders, low-grade inflammation, energy storage, host metabolism, gnotobiotic animals, probiotics, prebiotics, microbiota-host interactions
- MeSH terms
- Animals, Bifidobacterium, Homeostasis, Humans, Inflammation, Models, Biological, Obesity, Drug Delivery Systems, Mice, Knockout, Probiotics, Metabolic Syndrome, Gastrointestinal Tract, Mice, Metagenome, Prebiotics
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