The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Role of Hippocampal Cav1.2 Ca2+Channels in NMDA Receptor-Independent Synaptic Plasticity and Spatial Memory
Open accessAbstract
Current knowledge about the molecular mechanisms of NMDA receptor (NMDAR)-independent long-term potentiation (LTP) in the hippocampus and its function for memory formation in the behaving animal is limited. NMDAR-independent LTP in the CA1 region is thought to require activity of postsynaptic L-type voltage-dependent Ca 2+channels (Ca v 1.x), but the underlying channel isoform remains unknown. We evaluated the function of the Ca v 1.2 L-type Ca 2+channel for spatial learning, synaptic plasticity, and triggering of learning-associated biochemical processes using a mouse line with an inactivation of the CACNA1C(Ca v 1.2) gene in the hippocampus and neocortex (Ca v 1.2 HCKO). This model shows (1) a selective loss of protein synthesis-dependent NMDAR-independent Schaffer collateral/CA1 late-phase LTP (L-LTP), (2) a severe impairment of hippocampus-dependent spatial memory, and (3) decreased activation of the mitogen-activated protein kinase (MAPK) pathway and reduced cAMP response element (CRE)-dependent transcription in CA1 pyramidal neurons. Our results provide strong evidence for a role of L-type Ca 2+channel-dependent, NMDAR-independent hippocampal L-LTP in the formation of spatial memory in the behaving animal and for a function of the MAPK/CREB (CRE-binding protein) signaling cascade in linking Ca v 1.2 channel-mediated Ca 2+influx to either process.
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Metadata
- Authors
- Moosmang, S., Haider, N., Klugbauer, N., Adelsberger, H., Langwieser, N., Müller, J., Stiess, M., Marais, E., Schulla, V., Lacinova, L., Goebbels, S., Nave, K.-A., Storm, D. R., Hofmann, F., & Kleppisch, T.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-10-26
- Volume
- 25
- Issue
- 43
- Pages
- 9883-9892
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2128103118
- Cited by
- 417
- References
- 12
- FWCI
- 6.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
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