The Extracellular Matrix Molecule Hyaluronic Acid Regulates Hippocampal Synaptic Plasticity by Modulating Postsynaptic L-Type Ca2+ Channels
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SUMMARY Although the extracellular matrix plays an important role in regulating use-dependent synaptic plasticity, the underlying molecular mechanisms are poorly understood. Here we examined the synaptic function of hyaluronic acid (HA), a major component of the extracellular matrix. Enzymatic removal of HA with hyaluronidase reduced nifedipine-sensitive whole-cell Ca2+ currents, decreased Ca2+ transients mediated by L-type voltage-dependent Ca2+ channels (L-VDCCs) in postsynaptic dendritic shafts and spines, and abolished an L-VDCC-dependent component of long-term potentiation (LTP) at the CA3-CA1 synapses in the hippocampus. Adding exogenous HA, either by bath perfusion or via local delivery near recorded synapses, completely rescued this LTP component. In a heterologous expression system, exogenous HA rapidly increased currents mediated by Cav1.2, but not Cav1.3, subunit-containing L-VDCCs, whereas intrahippocampal injection of hyaluronidase impaired contextual fear conditioning. Our observations unveil a previously unrecognized mechanism by which the perisynaptic extracellular matrix influences use-dependent synaptic plasticity through regulation of dendritic Ca2+ channels.
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Digestion of hyaluronan reduces fear memory retrieval.
“The effectiveness of ChABC implicates CSPGs, but digestion of hyaluronan also reduces fear memory retrieval [61].”
From The extracellular matrix and perineuronal nets in memory (2022) · cites this paper as [61]
The Results section reports less freezing in the conditioned context after pretraining hyaluronidase injection, consistent with impaired contextual fear memory. But it says the effect could reflect impaired formation or retrieval; the Discussion adds that acquisition, consolidation, or retrieval may be involved. The paper does not establish a specific reduction in retrieval. (LLM, conf=0.88)
Experimental — accuracy not yet measuredMost studies in the hippocampal CA1 region show that PNN degradation or attenuation decreases long-term potentiation (LTP).
“Most studies in the hippocampal CA1 region show that PNN degradation or attenuation decreases long-term potentiation (LTP)[60–65].”
From The extracellular matrix and perineuronal nets in memory (2022) · cites this paper as [61]
Perineuronal nets (PNN) regulate synaptic plasticity and rewiring of the network of interneurons.
“Importantly, PNN regulate the synaptic plasticity (Kochlamazashvili et al., 2010) and rewiring the network (Pollock et al., 2014) of the interneurons (Wen et al., 2018).”
From Disrupted structural connectivity in ArcAβ mouse model of Aβ amyloidosis (2020) · cites this paper as Kochlamazashvili et al., 2010
These functions underlie the role of the adult ECM in neuronal excitability, receptor desensitization, long-term potentiation and long-term depression.
“Overall, these functions underlie the role of the adult ECM to neuronal excitability, receptor desensitization, long-term potentiation and long-term depression.59, 87, 88, 90, 91, 92, 93”
From Aggrecan and chondroitin-6-sulfate abnormalities in schizophrenia and bipolar disorder: a postmortem study on the amygdala (2015) · cites this paper as [90]
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Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles
Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126 · see citing works
Chondroitinase ABC promotes functional recovery after spinal cord injury
Bradbury, E. J., Moon, L. D. F., Popat, R. J., King, V. R., Bennett, G. S., Patel, P. N., Fawcett, J. W., & McMahon, S. B. (2002) · Nature · doi:10.1038/416636a · Cited by 2,357 · see citing works
Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex
Pizzorusso, T., Medini, P., Berardi, N., Chierzi, S., Fawcett, J. W., & Maffei, L. (2002) · Science · doi:10.1126/science.1072699 · Cited by 1,679 · see citing works
Memory Reconsolidation and Extinction Have Distinct Temporal and Biochemical Signatures
Suzuki, A., Josselyn, S. A., Frankland, P. W., Masushige, S., Silva, A. J., & Kida, S. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.5491-03.2004 · Cited by 1,127 · see citing works
Perineuronal Nets Protect Fear Memories from Erasure
Gogolla, N., Caroni, P., Lüthi, A., & Herry, C. (2009) · Science · doi:10.1126/science.1174146 · Cited by 760 · see citing works
Activation of CaMKII in single dendritic spines during long-term potentiation
Lee, S.-J. R., Escobedo-Lozoya, Y., Szatmari, E. M., & Yasuda, R. (2009) · Nature · doi:10.1038/nature07842 · Cited by 685 · see citing works
Lecticans: organizers of the brain extracellular matrix
Yamaguchi, Y. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000690 · Cited by 642 · see citing works
Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation
Back, S. A., Tuohy, T. M. F., Chen, H., Wallingford, N., Craig, A., Struve, J., Luo, N. L., Banine, F., Liu, Y., Chang, A., et al. (2005) · Nature Medicine · doi:10.1038/nm1279 · Cited by 612 · see citing works
Galtrey, C. M., & Fawcett, J. W. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.09.006 · Cited by 575 · see citing works
Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity
Frischknecht, R., Heine, M., Perrais, D., Seidenbecher, C. I., Choquet, D., & Gundelfinger, E. D. (2009) · Nature Neuroscience · doi:10.1038/nn.2338 · Cited by 554 · see citing works
Novel hyaluronidase from streptomyces
Takaichi, O. H. Y. A., & Kaneko, Y. (1970) · Biochimica et Biophysica Acta (BBA) - Enzymology · doi:10.1016/0005-2744(70)90139-7 · Cited by 519 · see citing works
α1D (Cav1.3) Subunits Can Form L-type Ca2+ Channels Activating at Negative Voltages
Koschak, A., Reimer, D., Huber, I. G., Grabner, M., Glossmann, H. H., Engel, J., & Striessnig, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101469200 · Cited by 454 · see citing works
Bauer, E. P., Schafe, G. E., & LeDoux, J. E. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-12-05239.2002 · Cited by 438 · see citing works
Moosmang, S., Haider, N., Klugbauer, N., Adelsberger, H., Langwieser, N., Müller, J., Stieß, M., Marais, E., Schulla, V., Lacinová, Ľ., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1531-05.2005 · Cited by 416 · see citing works
Dityatev, A., Brückner, G., Dityateva, G., Grosche, J., Kleene, R., & Schachner, M. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20361 · Cited by 365 · see citing works
Self-citationSnutch, T. P., Tomlinson, W. J., Leonard, J. P., & Gilbert, M. (1991) · Neuron · doi:10.1016/0896-6273(91)90073-9 · Cited by 362 · see citing works
Functional biology of the α2δ subunits of voltage-gated calcium channels
Davies, A., Hendrich, J., Tran-Van-Minh, A., Wratten, J., Douglas, L. R., & DOLPHIN, A. C. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.03.005 · Cited by 359 · see citing works
Brückner, G., Brauer, K., Härtig, W., Wolff, J. R., Rickmann, M. J., Derouiche, A., Delpech, B., Girard, N., Oertel, W. H., & Reichenbach, A. (1993) · Glia · doi:10.1002/glia.440080306 · Cited by 358 · see citing works
Aggrecan Glycoforms Contribute to the Molecular Heterogeneity of Perineuronal Nets
Matthews, R. T., Kelly, G. M., Zerillo, C. A., Gray, G., Tiemeyer, M., & Hockfield, S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07536.2002 · Cited by 341 · see citing works
Kohda, D., Morton, C. J., Parkar, A. A., Hatanaka, H., Inagaki, F., Campbell, I. D., & Day, A. J. (1996) · Cell · doi:10.1016/s0092-8674(00)80151-8 · Cited by 309 · see citing works
Neurofascin assembles a specialized extracellular matrix at the axon initial segment
Hedstrom, K. L., Xu, X., Ogawa, Y., Frischknecht, R., Seidenbecher, C. I., Shrager, P., & Rasband, M. N. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200705119 · Cited by 268 · see citing works
Brakebusch, C., Seidenbecher, C. I., Asztely, F., Rauch, U., Matthies, H., Meyer, H., Krug, M., Böckers, T. M., Zhou, X., Kreutz, M. R., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.21.7417-7427.2002 · Cited by 264 · see citing works
Plasticity of calcium channels in dendritic spines
Yasuda, R., Sabatini, B. L., & Svoboda, K. (2003) · Nature Neuroscience · doi:10.1038/nn1112 · Cited by 246 · see citing works
Bukalo, O., Schachner, M., & Dityatev, A. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00082-3 · Cited by 236 · see citing works
Self-citationSaghatelyan, A. K., Dityatev, A., Schmidt, S., Schuster, T., Bartsch, U., & Schachner, M. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0922 · Cited by 207 · see citing works
Self-citationInter‐α‐trypsin inhibitor proteoglycan family
Bost, F., Mehrpour, M., & Martin, J. (1998) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.1998.2520339.x · Cited by 206 · see citing works
Neurocan Is Dispensable for Brain Development
Zhou, X.-H., Brakebusch, C., Matthies, H., Oohashi, T., Hirsch, E., Moser, M., Krug, M., Seidenbecher, C. I., Boeckers, T. M., Rauch, U., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.17.5970-5978.2001 · Cited by 206 · see citing works
Rusakov, D. A., & Fine, A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00025-4 · Cited by 200 · see citing works
Self-citationNeuronal L-Type Calcium Channels Open Quickly and Are Inhibited Slowly
Helton, T. D., Xu, W., & Lipscombe, D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1089-05.2005 · Cited by 198 · see citing works
Hell, J. W., Westenbroek, R. E., Breeze, L. J., Wang, K., Chavkin, C., & Catterall, W. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.8.3362 · Cited by 198 · see citing works
Self-citationEvers, M. R., Salmen, B., Bukalo, O., Rollenhagen, A., Bösl, M. R., Morellini, F., Bartsch, U., Dityatev, A., & Schachner, M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07177.2002 · Cited by 172 · see citing works
Self-citationApostolova, I., Irintchev, A., & Schachner, M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1526-06.2006 · Cited by 166 · see citing works
Self-citationIncreased intraneuronal resting [Ca<sup>2+</sup>] in adult Alzheimer’s disease mice
Lopez, J. R., Lyckman, A., Oddo, S., LaFerla, F. M., Querfurth, H. W., & Shtifman, A. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05135.x · Cited by 162 · see citing works
Trifilieff, P., Herry, C., Vanhoutte, P., Caboche, J., Desmedt, A., Riedel, G., Mons, N. E., & Micheau, J. (2006) · Learning & Memory · doi:10.1101/lm.80206 · Cited by 161 · see citing works
Spatial segregation of neuronal calcium signals encodes different forms of LTP in rat hippocampus
Raymond, C. R., & Redman, S. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.098947 · Cited by 151 · see citing works
Specks, U., Mayer, U., Nischt, R., SPISSINGER, T., Mann, K., Timpl, R., Engel, J., & Chu, M. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05527.x · Cited by 149 · see citing works
Senkov, O., Sun, M., Weinhold, B., Gerardy‐Schahn, R., Schachner, M., & Dityatev, A. E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0878-06.2006 · Cited by 140 · see citing works
Self-citationDifferent Calcium Sources Are Narrowly Tuned to the Induction of Different Forms of LTP
Raymond, C. R., & Redman, S. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.88.1.249 · Cited by 137 · see citing works
Triggle, D. J. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206775474503 · Cited by 137 · see citing works
Brückner, G., Grosche, J., Hartlage‐Rübsamen, M., Schmidt, S., & Schachner, M. (2003) · Journal of Chemical Neuroanatomy · doi:10.1016/s0891-0618(03)00036-x · Cited by 116 · see citing works
Self-citationElectrical Stimuli Patterned After the Theta-Rhythm Induce Multiple Forms of LTP
Morgan, S. L., & Teyler, T. J. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.3.1289 · Cited by 113 · see citing works
Morellini, F., Sivukhina, E., Stoenica, L., Oulianova, E., Bukalo, O., Jakovcevski, I., Dityatev, A., Irintchev, A., & Schachner, M. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq017 · Cited by 104 · see citing works
Self-citationFacilitation of L-Type Ca2+Channels in Dendritic Spines by Activation of β2Adrenergic Receptors
Hoogland, T. M., & Saggau, P. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1677-04.2004 · Cited by 102 · see citing works
Huber, K. M., Mauk, M. D., & Kelly, P. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.73.1.270 · Cited by 102 · see citing works
Gui, P., Wu, X. Y., Ling, S., Stotz, S. C., Winkfein, R. J., Wilson, E., Davis, G. E., Braun, A. P., Zamponi, G. W., & Davis, M. J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600433200 · Cited by 97 · see citing works
Delling, M., Wischmeyer, E., Dityatev, A. E., Sytnyk, V., Veh, R. W., Karschin, A., & Schachner, M. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07154.2002 · Cited by 94 · see citing works
Self-citationCytoskeletal modulation of electrical and mechanical activity in cardiac myocytes
Calaghan, S. C., Guennec, J. Y. L., & White, E. (2003) · Progress in Biophysics and Molecular Biology · doi:10.1016/s0079-6107(03)00057-9 · Cited by 84 · see citing works
Regulation of Vascular L-type Ca 2+ Channels by Phosphatidylinositol 3,4,5-Trisphosphate
Blanc, C. L., Mironneau, C., Barbot, C., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000138017.76125.8b · Cited by 81 · see citing works
Hippocampal Metaplasticity Induced by Deficiency in the Extracellular Matrix Glycoprotein Tenascin-R
Bukalo, O., Schachner, M., & Dityatev, A. E. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1022-07.2007 · Cited by 80 · see citing works
Self-citationShinnick‐Gallagher, P., McKERNAN, M. G., Xie, J., & Zinebi, F. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07078.x · Cited by 76 · see citing works
Clark, N. C., Nagano, N., Kuenzi, F. M., Jarolimek, W., Huber, I. G., Walter, D., Wietzorrek, G., Boyce, S., Kullmann, D. M., Striessnig, J., et al. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00329-4 · Cited by 74 · see citing works
Saghatelyan, A. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00163-5 · Cited by 61 · see citing works
Knaus, H. G., Scheffauer, F., Romanin, C., et al. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38571-0 · Cited by 59 · see citing works
Peters, M., Bletsch, M., Catapano, R., Zhang, X., Tully, T., & Bourtchouladze, R. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00474.x · Cited by 56 · see citing works
Morellini, F., & Schachner, M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04657.x · Cited by 56 · see citing works
Self-citationRusakov, D. A., Saitow, F., Lehre, K. P., & Konishi, S. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0338-05.2005 · Cited by 47 · see citing works
Self-citationGlycosaminoglycans in Cortical Autopsy Samples from Alzheimer Brain
Jenkins, H. G., & Bachelard, H. S. (1988) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1988.tb01135.x · Cited by 36 · see citing works
Perosa, S. R., Porcionatto, M. A., Cukiert, A., Martins, J. R. M., Amado, D., Nader, H. B., Cavalheiro, É. A., Leite, J. P., & Naffah‐Mazzacoratti, M. D. G. (2002) · Epilepsia · doi:10.1046/j.1528-1157.43.s.5.30.x · Cited by 31 · see citing works
Dihydropyridine enantiomers block recombinant L‐type Ca2+ channels by two different mechanisms
Handrock, R., Rao‐Schymanski, R., Klugbauer, N., et al. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.00031.x · Cited by 21 · see citing works
Otoom, S. A.-A., & Hasan, Z. A. (2006) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2006.00393.x · Cited by 20 · see citing works
12-Lipoxygenase Regulates Hippocampal Long-Term Potentiation by Modulating L-Type Ca2+Channels
DeCostanzo, A. J., Voloshyna, I., Rosen, Z. B., Feinmark, S. J., & Siegelbaum, S. A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2168-09.2010 · Cited by 19 · see citing works
Evolution of the hyaluronan-binding module of link protein
Barta, E., Deák, F., & Kiss, I. (1993) · Biochemical Journal · doi:10.1042/bj2920947 · Cited by 13 · see citing works
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Fawcett, J. W., Oohashi, T., & Pizzorusso, T. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0196-3 · Cited by 589 · see citing works
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Carstens, K. E., Phillips, M. L., Pozzo-Miller, L., Weinberg, R. J., & Dudek, S. M. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.0245-16.2016 · Cited by 271 · see citing works
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Dityatev, A., & Rusakov, D. A. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.12.006 · Cited by 267 · see citing works
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Balmer, T. S. (2016) · eneuro · doi:10.1523/eneuro.0112-16.2016 · Cited by 220 · see citing works
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Finnie, P. S. B., & Nader, K. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.03.008 · Cited by 189 · see citing works
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Fawcett, J. W., Fyhn, M., Jendelova, P., Kwok, J. C. F., Ruzicka, J., & Sorg, B. A. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01634-3 · Cited by 169 · see citing works
Happel, M. F. K., Niekisch, H., Castiblanco Rivera, L. L., Ohl, F. W., Deliano, M., & Frischknecht, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310272111 · Cited by 176 · see citing works
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Self-citationHylin, M. J., Orsi, S. A., Moore, A. N., & Dash, P. K. (2013) · Learning & Memory · doi:10.1101/lm.030197.112 · Cited by 143 · see citing works
Morawski, M., Brückner, G., Jäger, C., Seeger, G., Matthews, R. T., & Arendt, T. (2012) · Brain Pathology · doi:10.1111/j.1750-3639.2011.00557.x · Cited by 157 · see citing works
Pantazopoulos, H., Markota, M., Jaquet, F., Ghosh, D., Wallin, A., Santos, A., Caterson, B., & Berretta, S. (2015) · Translational Psychiatry · doi:10.1038/tp.2014.128 · Cited by 153 · see citing works
Geissler, M., Gottschling, C., Aguado, A., Rauch, U., Wetzel, C. H., Hatt, H., & Faissner, A. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3275-12.2013 · Cited by 140 · see citing works
Wingert, J. C., & Sorg, B. A. (2021) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2021.673210 · Cited by 129 · see citing works
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Yoshino, Y., Shimazawa, M., Nakamura, S., Inoue, S., Yoshida, H., Shimoda, M., Okada, Y., & Hara, H. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.07.138 · Cited by 39 · see citing works
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“Importantly, PNN regulate the synaptic plasticity (Kochlamazashvili et al., 2010) and rewiring the network (Pollock et al., 2014) of the interneurons (Wen et al., 2018).”
Background
- Authors
- Kochlamazashvili, G., Henneberger, C., Bukalo, O., Dvoretskova, E., Senkov, O., Lievens, P. M.-J., Westenbroek, R., Engel, A. K., Catterall, W. A., Rusakov, D. A., Schachner, M., & Dityatev, A.
- Affiliations
- Universität Hamburg (DE)
- National Hospital for Neurology and Neurosurgery (GB)
- Italian Institute of Technology (IT)
- Heidelberg University (DE)
- University of Washington (US)
- University Medical Center Hamburg-Eppendorf (DE)
- Rutgers, The State University of New Jersey (US)
- Corresponding author
- Rusakov, Dmitri A.
- Dityatev, Alexander
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 67
- Issue
- 1
- Pages
- 116-128
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3378029
- OpenAlex
- W2044233502
- Semantic Scholar
- 868f9398c1e4d74bdf5af5a196e159f1aaa044e6
- Cited by
- 215
- References
- 62
- Citations by year
- 2026: 7 · 2025: 8 · 2024: 12 · 2023: 16 · 2022: 9 · 2021: 18 · 2020: 18 · 2019: 16 · 2018: 15 · 2017: 22 · 2016: 13 · 2015: 11 · 2014: 18 · 2013: 10 · 2012: 10
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1112 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Rutgers University Community Repository (Rutgers University) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Istituto Italiano di Tecnologia
- Wellcome Trust
- Medical Research Council
- New Jersey Commission on Spinal Cord Research
- Deutsche Forschungsgemeinschaft (DI 702/6-1)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- hyaluronic acid, extracellular matrix, L-type calcium channels, synaptic plasticity, long-term potentiation, hippocampus, CA3-CA1 synapses, hyaluronidase, contextual fear conditioning
- MeSH terms
- Analysis of Variance, Animals, 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester, Calcium Channel Agonists, Calcium Channel Blockers, Conditioning, Classical, Cricetulus, Drug Interactions, Electric Stimulation, Fear, Female, Cricetinae, Hippocampus, Hyaluronic Acid, Hyaluronoglucosaminidase, Male, Mice, Inbred C57BL, Nifedipine, Synapses, Transfection, CHO Cells, Long-Term Potentiation, Patch-Clamp Techniques, Calcium Channels, L-Type, Mice, In Vitro Techniques
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