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Similar Roles of Substantia Nigra and Ventral Tegmental Dopamine Neurons in Reward and Aversion

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Ilango, Anton, Kesner, Andrew J., Keller, Kristine L., Stuber, Garret D., Bonci, Antonello, Ikemoto, Satoshi·2014·The Journal of Neuroscience

DOI 10.1523/jneurosci.1703-13.2014PMC PMC3891961

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Abstract

Dopamine neurons in the ventral tegmental area (VTA) are implicated in affective functions. However, it is unclear to what extent dopamine neurons in substantia nigra pars compacta (SNc) play such roles. TH-Cre transgenic mice received adeno-associated viral vectors encoding channelrhodopsin2 (ChR2), halorhodopsin (NpHR), or control vector into the VTA or SNc, resulting in selective expression of these opsins in dopamine neurons. Mice with ChR2 learned instrumental responding to deliver photostimulation into the VTA or SNc and also sought for the compartment where they received photostimulation (i.e., operant place preference). Operant place preference scores were highly correlated with self-stimulation responses. In contrast, mice with NpHR avoided the compartment where they received photostimulation into the VTA, SNc, or dorsal striatum, whereas control mice did not. These observations suggest that the excitation and inhibition of SNc dopamine neurons elicit positive and negative affective effects, respectively, similar to those of VTA dopamine neurons.

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Authors: Ilango, A., Kesner, A. J., Keller, K. L., Stuber, G. D., Bonci, A., & Ikemoto, S.
Affiliations: University of North Carolina at Chapel Hill (US)
National Institutes of Health (US)
ORCID: Kesner, Andrew J.
Stuber, Garret D.
Bonci, Antonello
Ikemoto, Satoshi
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2014-01-15
Volume: 34
Issue: 3
Pages: 817-822
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.1703-13.2014
PMC: PMC3891961
OpenAlex: W1964812893
Cited by: 255
References: 33
Citations by year: 2026: 2 · 2025: 18 · 2024: 14 · 2023: 16 · 2022: 14 · 2021: 23 · 2020: 20 · 2019: 24 · 2018: 28 · 2017: 20 · 2016: 28 · 2015: 33 · 2014: 15
FWCI: 14.62
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
UNC Libraries
Funders: National Institutes of Health
National Institute on Drug Abuse (R01DA032750)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: substantia nigra pars compacta, ventral tegmental area, dopaminergic neurons, reward, aversion, self-stimulation, photostimulation, halorhodopsin, emotional behavior, dorsal striatum
MeSH terms: Animals, Avoidance Learning, Conditioning, Operant, Male, Mice, Inbred C57BL, Reward, Substantia Nigra, Ventral Tegmental Area, Mice, Gene Knock-In Techniques, Dopaminergic Neurons

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Similar Roles of Substantia Nigra and Ventral Tegmental Dopamine Neurons in Reward and Aversion

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