Differential Gating and Recruitment of P/Q-, N-, and R-Type Ca2+Channels in Hippocampal Mossy Fiber Boutons
Open accessAbstract
Voltage-gated Ca 2+channels in presynaptic terminals initiate the Ca 2+inflow necessary for transmitter release. At a variety of synapses, multiple Ca 2+channel subtypes are involved in synaptic transmission and plasticity. However, it is unknown whether presynaptic Ca 2+channels differ in gating properties and whether they are differentially activated by action potentials or subthreshold voltage signals. We examined Ca 2+channels in hippocampal mossy fiber boutons (MFBs) by presynaptic recording, using the selective blockers ω-agatoxin IVa, ω-conotoxin GVIa, and SNX-482 to separate P/Q-, N-, and R-type components. Nonstationary fluctuation analysis combined with blocker application revealed a single MFB contained on average ∼2000 channels, with 66% P/Q-, 26% N-, and 8% R-type channels. Whereas both P/Q-type and N-type Ca 2+channels showed high activation threshold and rapid activation and deactivation, R-type Ca 2+channels had a lower activation threshold and slower gating kinetics. To determine the efficacy of activation of different Ca 2+channel subtypes by physiologically relevant voltage waveforms, a six-state gating model reproducing the experimental observations was developed. Action potentials activated P/Q-type Ca 2+channels with high efficacy, whereas N- and R-type channels were activated less efficiently. Action potential broadening selectively recruited N- and R-type channels, leading to an equalization of the efficacy of channel activation. In contrast, subthreshold presynaptic events activated R-type channels more efficiently than P/Q- or N-type channels. In conclusion, single MFBs coexpress multiple types of Ca 2+channels, which are activated differentially by subthreshold and suprathreshold presynaptic voltage signals.
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CaV2.1 is the major type of presynaptic Ca2+ channel in mossy fiber boutons.
“we targeted CaV2.1, the major type of presynaptic Ca2+ channel in MFBs [58,59]”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [59]
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- Authors
- Li, L., Bischofberger, J., & Jonas, P.
- Affiliations
- University of Freiburg (DE)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-12-05
- Volume
- 27
- Issue
- 49
- Pages
- 13420-13429
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673086
- OpenAlex
- W2084434180
- Cited by
- 206
- References
- 59
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 13 · 2023: 18 · 2022: 9 · 2021: 8 · 2020: 6 · 2019: 13 · 2018: 10 · 2017: 10 · 2016: 4 · 2015: 6 · 2014: 16 · 2013: 8 · 2012: 15
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB 505)
- Leibniz-Gemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- voltage-gated calcium channels, P/Q-type calcium channels, N-type calcium channels, R-type calcium channels, presynaptic terminals, channel gating kinetics, action potential broadening, synaptic transmission, omega-agatoxin IVA, omega-conotoxin GVIA, SNX-482, hippocampus
- MeSH terms
- Animals, Electric Stimulation, Synaptic Transmission, Recruitment, Neurophysiological, Calcium Channels, Ion Channel Gating, Rats, Wistar, Presynaptic Terminals, Mossy Fibers, Hippocampal, Calcium Channels, N-Type, Calcium Channels, P-Type, Calcium Channels, R-Type, Rats
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