The DOI matches its Crossref record; 36 of the 37 references it cites were found in a registry or an index.
Facilitation of Affiliation and Pair-Bond Formation by Vasopressin Receptor Gene Transfer into the Ventral Forebrain of a Monogamous Vole
Open accessAbstract
Behaviors associated with monogamy, including pair-bond formation, are facilitated by the neuropeptide vasopressin and are prevented by a vasopressin receptor [V1a receptor (V1aR)] antagonist in the male prairie vole. The neuroanatomical distribution of V1aR dramatically differs between monogamous and nonmonogamous species. V1aR binding is denser in the ventral pallidal region of several unrelated monogamous species compared with nonmonogamous species. Because the ventral pallidum is involved in reinforcement and addiction, we hypothesize that V1aR activation in this region promotes pair-bond formation via a mechanism similar to conditioning. Using an adeno-associated viral vector to deliver the V1aR gene, we increased the density of V1aR binding in the ventral pallial region of male prairie voles. These males exhibited increased levels of both anxiety and affiliative behavior compared with control males. In addition, males overexpressing the V1aR in the ventral pallidal region, but not control males, formed strong partner preferences after an overnight cohabitation, without mating, with a female. These data demonstrate a role for ventral pallidal V1aR in affiliation and social attachment and provide a potential molecular mechanism for species differences in social organization.
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“Conversely, viral-mediated increases in VP AVPR1a expression induce partner preferences and increase affiliative behaviors in male prairie voles that are sexually naïve and, interestingly, also lead to partner preference formation in non-monogamous meadow voles [138,146].”
From The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives (2023) · cites this paper as [146]
Experimental — accuracy not yet measuredIn the citing paper
“partner preference formation in prairie voles is modulated by the VP system acting in the LS and ventral pallidum (Liu et al., 2001; Pitkow et al., 2001; Lim & Young, 2004) and by the OT system acting in the NAc and prefrontal cortex (Young et al., 2001; Liu and Wang, 2003).”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Pitkow et al., 2001
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Cites
Affective Neuroscience: The Foundations of Human and Animal Emotions
Panksepp, J. (1998) · doi:10.1093/oso/9780195096736.001.0001 · Cited by 4,428
Neuroendocrine perspectives on social attachment and love
Sue Carter, C. (1998) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(98)00055-9 · Cited by 1,425
The neurobiology of attachment
Insel, T. R., & Young, L. J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35053579 · Cited by 1,173
Self-citationThe neural basis of romantic love
Bartels, A., & Zeki, S. (2000) · NeuroReport · doi:10.1097/00001756-200011270-00046 · Cited by 1,020
A role for central vasopressin in pair bonding in monogamous prairie voles
Winslow, J. T., Hastings, N., Carter, C. S., Harbaugh, C. R., & Insel, T. R. (1993) · Nature · doi:10.1038/365545a0 · Cited by 948 · cited 3×
“Conversely, central infusions of AVP facilitate partner-preference formation even in the absence of mating (Winslow et al., 1993).”
BackgroundSelf-citationOxytocin receptor distribution reflects social organization in monogamous and polygamous voles
Insel, T. R., & Shapiro, L. E. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.13.5981 · Cited by 833
Self-citationMcBride, W. J., Murphy, J. M., & Ikemoto, S. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00022-4 · Cited by 574
Cho, M. M., DeVries, A. C., Williams, J. R., & Carter, C. S. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.5.1071 · Cited by 529
Insel, T. R., & Hulihan, T. J. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.4.782 · Cited by 528
Self-citationde Vries, G. J., & Buijs, R. M. (1983) · Brain Research · doi:10.1016/0006-8993(83)90855-7 · Cited by 524 · cited 1×
“In rats, the septal AVP innervation arises from the bed nucleus of the stria terminalis and the medial amygdala ( DeVries and Buijs, 1983 ).”
BackgroundCellular Mechanisms of Social Attachment
Young, L. J., Lim, M. M., Gingrich, B., & Insel, T. R. (2001) · Hormones and Behavior · doi:10.1006/hbeh.2001.1691 · Cited by 523
Self-citationYoung, L. J., Nilsen, R., Waymire, K. G., MacGregor, G. R., & Insel, T. R. (1999) · Nature · doi:10.1038/23475 · Cited by 488
Self-citationInsel, T., Wang, Z., & Ferris, C. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-09-05381.1994 · Cited by 454
Self-citationWotjak, C. T., Ganster, J., Kohl, G., Holsboer, F., Landgraf, R., & Engelmann, M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00683-0 · Cited by 345
Landgraf, R., Gerstberger, R., Montkowski, A., Probst, J., Wotjak, C., Holsboer, F., & Engelmann, M. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-06-04250.1995 · Cited by 341
Gingrich, B., Liu, Y., Cascio, C., Wang, Z., & Insel, T. R. (2000) · Behavioral Neuroscience · doi:10.1037/0735-7044.114.1.173 · Cited by 339
Self-citationChanges in oxytocin and vasopressin secretion during sexual activity in men
MURPHY, M. R., SECKL, J. R., BURTON, S., CHECKLEY, S. A., & LIGHTMAN, S. L. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-4-738 · Cited by 318
Carter, C. S., & Getz, L. L. (1993) · Scientific American · doi:10.1038/scientificamerican0693-100 · Cited by 310 · cited 1×
“Both field and laboratory studies have demonstrated that prairie voles (Microtus ochrogaster) are a highly gregarious species that forms enduring, selective social bonds between mates (Shapiro and Dewsbury, 1990; Carter and Getz, 1993).”
BackgroundSelective and Rapid Uptake of Adeno-Associated Virus Type 2 in Brain
Bartlett, J. S., Samulski, R. J., & McCown, T. J. (1998) · Human Gene Therapy · doi:10.1089/hum.1998.9.8-1181 · Cited by 301
Peel, A., Zolotukhin, S., Schrimsher, G. W., Muzyczka, N., & Reier, P. J. (1997) · Gene Therapy · doi:10.1038/sj.gt.3300358 · Cited by 289
Bester‐Meredith, J. K., Young, L. J., & Marler, C. A. (1999) · Hormones and Behavior · doi:10.1006/hbeh.1999.1522 · Cited by 285
Self-citationLiu, Y., Curtis, J. T., & Wang, Z. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.4.910 · Cited by 282
Neuroendocrine bases of monogamy
Young, L. J., Wang, Z., & Insel, T. R. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(97)01167-3 · Cited by 265
Self-citationWotjak, C. T., Kubota, M., Liebsch, G., Montkowski, A., Holsboer, F., Neumann, I. D., & Landgraf, R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-23-07725.1996 · Cited by 231
Mating in the monogamous male: Behavioral consequences
Insel, T. R., Preston, S., & Winslow, J. T. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(94)00362-9 · Cited by 215
Self-citationOxytocin and Vasopressin Receptors and Species-Typical Social Behaviors
Young, L. J. (1999) · Hormones and Behavior · doi:10.1006/hbeh.1999.1548 · Cited by 211
Self-citationYoung, L. J., Winslow, J. T., Nilsen, R., & Insel, T. R. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.3.599 · Cited by 196
Self-citationKlitenick, M. A., Deutch, A. Y., Churchill, L., & Kalivas, P. W. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90430-a · Cited by 182
Septal vasopressin modulates anxiety-related behaviour in rats
Liebsch, G., Wotjak, C. T., Landgraf, R., & Engelmann, M. (1996) · Neuroscience Letters · doi:10.1016/0304-3940(96)13069-x · Cited by 173
Localization of Vasopressin (V1a) Receptor Binding and mRNA in the Rhesus Monkey Brain
Young, Toloczko, & Insel (1999) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1999.00332.x · Cited by 139 · cited 4×
“In this same region, relatively little V1aR binding is detectable in related nonmonogamous montane (M. montanus) and meadow (M. pennsylvanicus) voles, white-footed mice (Peromyscus leucopus), and rhesus monkeys (Insel et al., 1994; Bester-Meredith et al., 1999; Young, 1999; Young et al., 1999b ).”
BackgroundInfluentialWu, P., Phillips, M. I., Bui, J., & Terwilliger, E. F. (1998) · Journal of Virology · doi:10.1128/jvi.72.7.5919-5926.1998 · Cited by 137
Self-citationGong, W., Neill, D. B., & Justice, J. B. (1996) · Brain Research · doi:10.1016/0006-8993(95)01222-2 · Cited by 134
Wange, R. L., Smrcka, A. V., Sternweis, P. C., & Exton, J. H. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98970-2 · Cited by 100
Shapiro, L. E., & Dewsbury, D. A. (1990) · Journal of comparative psychology · doi:10.1037/0735-7036.104.3.268 · Cited by 95
Straková, Z., Kumar, A., Watson, A. J., & Soloff, M. S. (1997) · Molecular Pharmacology · doi:10.1124/mol.51.2.217 · Cited by 17
Wang (1996) · doi:10.1002/(sici)1096-9861(19960318)366:4
Self-citation
Research works printed but not linked: 1
- Panksepp J (1998) Affective neuroscience (Davidson RJ, Ekman P, Scherer K, eds). New York: Oxford UP.
Cited by
Sorted by citations
The neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523
Self-citationInsel, T. R. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.005 · Cited by 1,044
Self-citationAre Political Orientations Genetically Transmitted?
Alford, J. R., Funk, C. L., & Hibbing, J. R. (2005) · American Political Science Review · doi:10.1017/s0003055405051579 · Cited by 995
Neumann, I. D., & Landgraf, R. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.08.004 · Cited by 954
The development of animal personality: relevance, concepts and perspectives
Stamps, J. A., & Groothuis, T. G. G. (2009) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2009.00103.x · Cited by 979
Metadata
- Authors
- Pitkow, L. J., Sharer, C. A., Ren, X., Insel, T. R., Terwilliger, E. F., & Young, L. J.
- Affiliations
- Emory University (US)
- Beth Israel Deaconess Medical Center (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-09-15
- Volume
- 21
- Issue
- 18
- Pages
- 7392-7396
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6762997
- OpenAlex
- W2127294078
- Cited by
- 295
- References
- 37
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 9 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 5 · 2018: 9 · 2017: 14 · 2016: 21 · 2015: 10 · 2014: 17 · 2013: 11 · 2012: 18
- FWCI
- 30.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (9876754)
- U.S. Public Health Service (58824, 56897)
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- vasopressin V1a receptor, pair bonding, monogamy, Microtus ochrogaster, ventral pallidum, affiliative behavior, anxiety, mate preferences, social attachment, neuropeptide signaling
- MeSH terms
- Dependovirus, Animals, Anxiety, Autoradiography, Choice Behavior, Arvicolinae, Genetic Vectors, Globus Pallidus, Male, Pair Bond, Sexual Behavior, Animal, Social Facilitation, Prosencephalon, Receptors, Vasopressin, Maze Learning, Gene Transfer, Horizontal
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