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Facilitation of Affiliation and Pair-Bond Formation by Vasopressin Receptor Gene Transfer into the Ventral Forebrain of a Monogamous Vole
Open accessAbstract
Behaviors associated with monogamy, including pair-bond formation, are facilitated by the neuropeptide vasopressin and are prevented by a vasopressin receptor [V1a receptor (V1aR)] antagonist in the male prairie vole. The neuroanatomical distribution of V1aR dramatically differs between monogamous and nonmonogamous species. V1aR binding is denser in the ventral pallidal region of several unrelated monogamous species compared with nonmonogamous species. Because the ventral pallidum is involved in reinforcement and addiction, we hypothesize that V1aR activation in this region promotes pair-bond formation via a mechanism similar to conditioning. Using an adeno-associated viral vector to deliver the V1aR gene, we increased the density of V1aR binding in the ventral pallial region of male prairie voles. These males exhibited increased levels of both anxiety and affiliative behavior compared with control males. In addition, males overexpressing the V1aR in the ventral pallidal region, but not control males, formed strong partner preferences after an overnight cohabitation, without mating, with a female. These data demonstrate a role for ventral pallidal V1aR in affiliation and social attachment and provide a potential molecular mechanism for species differences in social organization.
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“Conversely, viral-mediated increases in VP AVPR1a expression induce partner preferences and increase affiliative behaviors in male prairie voles that are sexually naïve and, interestingly, also lead to partner preference formation in non-monogamous meadow voles [138,146].”
From The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives (2023) · cites this paper as [146]
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“partner preference formation in prairie voles is modulated by the VP system acting in the LS and ventral pallidum (Liu et al., 2001; Pitkow et al., 2001; Lim & Young, 2004) and by the OT system acting in the NAc and prefrontal cortex (Young et al., 2001; Liu and Wang, 2003).”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Pitkow et al., 2001
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Metadata
- Authors
- Pitkow, L. J., Sharer, C. A., Ren, X., Insel, T. R., Terwilliger, E. F., & Young, L. J.
- Affiliations
- Emory University (US)
- Beth Israel Deaconess Medical Center (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-09-15
- Volume
- 21
- Issue
- 18
- Pages
- 7392-7396
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6762997
- OpenAlex
- W2127294078
- Cited by
- 295
- References
- 37
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 9 · 2023: 4 · 2022: 5 · 2021: 9 · 2020: 6 · 2019: 5 · 2018: 9 · 2017: 14 · 2016: 21 · 2015: 10 · 2014: 17 · 2013: 11 · 2012: 18
- FWCI
- 30.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (9876754)
- U.S. Public Health Service (58824, 56897)
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- vasopressin V1a receptor, pair bonding, monogamy, Microtus ochrogaster, ventral pallidum, affiliative behavior, anxiety, mate preferences, social attachment, neuropeptide signaling
- MeSH terms
- Dependovirus, Animals, Anxiety, Autoradiography, Choice Behavior, Arvicolinae, Genetic Vectors, Globus Pallidus, Male, Pair Bond, Sexual Behavior, Animal, Social Facilitation, Prosencephalon, Receptors, Vasopressin, Maze Learning, Gene Transfer, Horizontal
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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