The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Circadian and Homeostatic Regulation of Hypocretin in a Primate Model: Implications for the Consolidation of Wakefulness
Open accessAbstract
In humans, consolidation of wakefulness into a single episode can be modeled as the interaction of two processes, a homeostatic "hour-glass" wake signal that declines throughout the daytime and a circadian wake-promoting signal that peaks in the evening. Hypocretins, novel hypothalamic neuropeptides that are dysfunctional in the sleep disorder narcolepsy, may be involved in the expression of the circadian wake-promoting signal. Hypocretins (orexins) are wake-promoting peptides, but their role in normal human sleep physiology has yet to be determined. We examined the daily temporal pattern of hypocretin-1 in the cisternal CSF of the squirrel monkey, a New World primate with a pattern of wake similar to that of humans. Hypocretin-1 levels peaked in the latter third of the day, consistent with the premise that hypocretin-1 is involved in wake regulation. When we lengthened the wake period by 4 hr, hypocretin-1 concentrations remained elevated, indicating a circadian-independent component to hypocretin-1 regulation. Changes in the stress hormone cortisol were not correlated with hypocretin-1 changes. Although hypocretin-1 is at least partially activated by a reactive homeostatic mechanism, it is likely also regulated by the circadian pacemaker. In the squirrel monkey, hypocretin-1 works in opposition to the accumulating sleep drive during the day to maintain a constant level of wake.
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The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity
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“Preprohypocretin, the precursor to hypocretin-1, is also cleaved to form hypocretin-2 (de Lecea et al., 1998; Sakurai et al., 1998), which we assayed using a commercially available RIA (Phoenix Pharmaceuticals).”
BackgroundMethodNeurons containing hypocretin (orexin) project to multiple neuronal systems
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Age‐related Changes in the Circadian and Homeostatic Regulation of Human Sleep
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The Neurobiology of Sleep and Wakefulness
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Self-citationSleep-Wake Disturbances After Traumatic Brain Injury: Synthesis of Human and Animal Studies
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“Mother–infant pairs were captured and released twice at each age, on different days, to obtain an early morning sample (at sunrise) and an evening sample (at sunset) for analysis of diurnal cortisol secretion (Sanchez et al., 2005; Zeitzer et al., 2003).”
MethodSleep Neurobiology for the Clinician
(2004) · Sleep · doi:10.1093/sleep/27.4.811 · Cited by 151
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Kalsbeek, A., Scheer, F. A., Perreau-Lenz, S., La Fleur, S. E., Yi, C.-X., Fliers, E., & Buijs, R. M. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.021 · Cited by 133
“In view of the pronounced day/night-rhythm in orexin release [95,96] we hypothesized that orexin is the main connection between the biological clock and the daily rhythm in plasma glucose concentrations.”
BackgroundThe discovery of suvorexant, the first orexin receptor drug for insomnia
Coleman, P. J., Gotter, A. L., Herring, W. J., Winrow, C. J., & Renger, J. J. (2017) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010716-104837 · Cited by 128
Mild early life stress enhances prefrontal-dependent response inhibition in monkeys
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Self-citation
Metadata
- Authors
- Zeitzer, J. M., Buckmaster, C. L., Parker, K. J., Hauck, C. M., Lyons, D. M., & Mignot, E.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-04-15
- Volume
- 23
- Issue
- 8
- Pages
- 3555-3560
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1570515437
- Cited by
- 277
- References
- 5
- FWCI
- 10.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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