Deterministic Multiplicative Gain Control with Active Dendrites
Open accessAbstract
Multiplicative gain control is a vital component of many theoretical analyses of neural computations, conferring the ability to scale neuronal firing rate in response to synaptic inputs. Many theories of gain control in single cells have used precisely balanced noisy inputs. Such noisy inputs can degrade signal processing. We demonstrate a deterministic method for the control of gain without the use of noise. We show that a depolarizing afterpotential (DAP), arising from active dendritic spike backpropagation, leads to a multiplicative increase in gain. Reduction of DAP amplitude by dendritic inhibition dilutes the multiplicative effect, allowing for divisive scaling of the firing rate. In contrast, somatic inhibition acts in a subtractive manner, allowing spatially distinct inhibitory inputs to perform distinct computations. The simplicity of this mechanism and the ubiquity of its elementary components suggest that many cell types have the potential to display a dendritic division of neuronal output.
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The gain enhancement conferred by dendritic action potentials may be counterbalanced in part by the distinct multiplicative effects and subtractive effects of dendritic inhibition and somatic inhibition, respectively.
“In turn, the gain enhancement conferred by dendritic action potentials may be counterbalanced in part by the distinct multiplicative effects and subtractive effects of dendritic inhibition and somatic inhibition, respectively95.”
From Mechanisms underlying gain modulation in the cortex (2020) · cites this paper as [95]
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Self-citation
- Authors
- Mehaffey, W. H., Doiron, B., Maler, L., & Turner, R. W.
- Affiliations
- University of Calgary (CA)
- University of Ottawa (CA)
- Corresponding author
- Mehaffey, W. Hamish
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-10-26
- Volume
- 25
- Issue
- 43
- Pages
- 9968-9977
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6725553
- OpenAlex
- W2148773920
- Cited by
- 120
- References
- 55
- Citations by year
- 2025: 3 · 2024: 7 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 5 · 2016: 7 · 2015: 4 · 2014: 7 · 2013: 6 · 2012: 8
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fondation pour la Recherche Médicale
- Alberta Heritage Foundation for Medical Research
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Advanced Memory and Neural Computing
- Keywords
- active dendrites, depolarizing afterpotential, dendritic inhibition, somatic inhibition, dendritic computation
- MeSH terms
- Action Potentials, Anesthetics, Local, Animals, Brain, Dendrites, Dose-Response Relationship, Radiation, Electric Stimulation, Feedback, Fishes, Models, Neurological, Muscimol, Neural Inhibition, Sodium, Synapses, Tetrodotoxin, Time Factors, Pyramidal Cells, GABA Agonists, In Vitro Techniques
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