Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 666

The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.

Aberrant Frontal and Temporal Complex Network Structure in Schizophrenia: A Graph Theoretical Analysis

Open access
van den Heuvel, Martijn P., Mandl, René C. W., Stam, Cornelis J., Kahn, René S., Hulshoff Pol, Hilleke E.·2010·The Journal of Neuroscience
DOI 10.1523/jneurosci.2874-10.2010
Open this paper in CoChat — free account

Abstract

Brain regions are not independent. They are interconnected by white matter tracts, together forming one integrative complex network. The topology of this network is crucial for efficient information integration between brain regions. Here, we demonstrate that schizophrenia involves an aberrant topology of the structural infrastructure of the brain network. Using graph theoretical analysis, complex structural brain networks of 40 schizophrenia patients and 40 human healthy controls were examined. Diffusion tensor imaging was used to reconstruct the white matter connections of the brain network, with the strength of the connections defined as the level of myelination of the tracts as measured through means of magnetization transfer ratio magnetic resonance imaging. Patients displayed a preserved overall small-world network organization, but focusing on specific brain regions and their capacity to communicate with other regions of the brain revealed significantly longer node-specific path lengths (higher L) of frontal and temporal regions, especially of bilateral inferior/superior frontal cortex and temporal pole regions. These findings suggest that schizophrenia impacts global network connectivity of frontal and temporal brain regions. Furthermore, frontal hubs of patients showed a significant reduction of betweenness centrality, suggesting a less central hub role of these regions in the overall network structure. Together, our findings suggest that schizophrenia patients have a less strongly globally integrated structural brain network with a reduced central role for key frontal hubs, resulting in a limited structural capacity to integrate information across brain regions.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1523/jneurosci.2874-10.2010

Cites

22 of 22 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Research works printed but not linked: 52

  1. 10.1523/JNEUROSCI.3874-05.2006 · DOI · Paper page
  2. 10.1006/nimg.2001.1039 · DOI · Paper page
  3. 10.1001/archpsyc.1992.01820080023004 · DOI · Paper page
  4. 10.1192/bjp.bp.108.059717 · DOI · Paper page
  5. 10.1006/jmrb.1996.0086 · DOI · Paper page
  6. 10.1523/JNEUROSCI.1929-08.2008 · DOI · Paper page
  7. 10.1073/pnas.0903641106 · DOI · Paper page
  8. 10.1016/j.neuroimage.2004.12.053 · DOI · Paper page
  9. 10.1001/archpsyc.64.3.297 · DOI · Paper page
  10. 10.1023/B:NERE.0000021242.12455.75 · DOI
  11. Camchong J Macdonald AW 3rd Bell C Mueller BA Lim KO (2009) Altered functional and anatomical connectivity in schizophrenia. Schizophr Bull, Advance online publication. Retrieved November 17, 2009. doi:10.1093/schbul/sbp131 . · DOI · Paper page
  12. 10.1016/j.schres.2009.12.022 · DOI · Paper page
  13. 10.1093/brain/124.5.882 · DOI
  14. 10.1016/S0920-9964(97)00140-0 · DOI · Paper page
  15. 10.1073/pnas.0811168106 · DOI · Paper page
  16. 10.1016/j.neuroimage.2010.01.071 · DOI · Paper page
  17. 10.1093/schbul/sbm168 · DOI · Paper page
  18. 10.1016/j.neuroimage.2003.09.026 · DOI
  19. 10.1016/j.cortex.2008.05.002 · DOI · Paper page
  20. 10.1371/journal.pcbi.0020095 · DOI · Paper page
  21. 10.1016/j.biopsych.2005.05.015 · DOI · Paper page
  22. 10.1002/mrm.21316 · DOI
  23. 10.1017/S0033291702005287 · DOI
  24. 10.1097/00001504-200503000-00004 · DOI
  25. 10.1016/j.neuroimage.2005.03.026 · DOI · Paper page
  26. 10.1016/j.jpsychires.2005.05.005 · DOI · Paper page
  27. 10.1103/PhysRevLett.87.198701 · DOI · Paper page
  28. 10.1093/brain/awn018 · DOI · Paper page
  29. 10.1523/JNEUROSCI.0333-10.2010 · DOI · Paper page
  30. 10.1371/journal.pone.0003631 · DOI
  31. 10.1093/schbul/sbn161 · DOI
  32. Mannell, 2010, Resting state and task-induced deactivation: a methodological comparison in patients with schizophrenia and healthy controls, Hum Brain Mapp, 31, 424, 10.1002/hbm.20876 · DOI
  33. 10.1371/journal.pone.0007911 · DOI
  34. 10.1016/j.schres.2006.06.028 · DOI · Paper page
  35. 10.1002/nbm.781 · DOI · Paper page
  36. 10.1016/j.clinph.2007.08.010 · DOI · Paper page
  37. 10.1001/archpsyc.1988.01800360017003 · DOI · Paper page
  38. 10.1016/j.neuroimage.2009.10.003 · DOI · Paper page
  39. Sommer, 2003, Language lateralization in female patients with schizophrenia: an fMRI study, Schizophr Res, 60, 183, 10.1016/S0920-9964(02)00300-6 · DOI
  40. 10.1385/NI:2:2:145 · DOI · Paper page
  41. 10.1371/journal.pone.0001049 · DOI · Paper page
  42. 10.1093/brain/awn262 · DOI · Paper page
  43. 10.1097/00001756-200310060-00015 · DOI
  44. 10.1006/nimg.2001.0978 · DOI · Paper page
  45. 10.1097/00004728-199911001-00003 · doi:10.1097/00004728-199911001-00003
  46. 10.1016/j.neuroimage.2008.08.010 · DOI · Paper page
  47. 10.1093/brain/awq040 · DOI
  48. 10.1038/30918 · DOI · Paper page
  49. 10.1016/j.pscychresns.2005.11.003 · DOI
  50. 10.1148/radiology.192.3.8058919 · DOI · Paper page
  51. Wright, 2000, Meta-analysis of regional brain volumes in schizophrenia, Am J Psychiatry, 157, 16, 10.1176/ajp.157.1.16 · DOI · Paper page
  52. 10.1016/j.schres.2007.11.039 · DOI · Paper page

Cited by

See all 666

Metadata

Authors
van den Heuvel, M. P., Mandl, R. C. W., Stam, C. J., Kahn, R. S., & Hulshoff Pol, H. E.
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
2010-11-24
Volume
30
Issue
47
Pages
15915-15926
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.2874-10.2010
OpenAlex
W2058711140
Cited by
666
References
22
FWCI
24.80
Type
journal article
Language
en
Open access
hybrid
Licence
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.