Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environment
Open accessAbstract
Locus ceruleus (LC) neuronal activity is correlated with the waking state, yet LC lesions produce only minor alterations in daily wakefulness. Here, we report that sustained elevations in neurobehavioral and EEG arousal in response to exposure to an environment with novel stimuli, including social interaction, are prevented by selective chemical lesions of the LC in rats. Similar results are seen when the anterior cingulate cortex (ACC), which receives especially dense LC innervation, is selectively denervated of LC input or is ablated by the cell-specific neurotoxin ibotenic acid. Anterograde tracing combined with tyrosine hydroxylase immunohistochemistry demonstrates ACC terminals in apposition with the distal dendrites of LC neurons. Our data implicate the ACC as both a source of input to the LC as well as one of its targets and suggests that the two structures engage in a dialog that may provide a critical neurobiological substrate for sustained attention.
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If the stimulus is evaluated as rewarding or salient, the phasic mode is maintained through frequent firing bursts of LC-NE neurons and release of NE, supporting sustained attention over time.
“Conversely, if the stimulus is evaluated as rewarding or salient, the phasic mode is maintained through frequent firing bursts of LC-NE neurons and release of NE, supporting sustained attention over time (Gompf et al., 2010).”
From Is autonomic nervous system function atypical in Attention Deficit Hyperactivity Disorder (ADHD)? A systematic review of the evidence (2020) · cites this paper as Gompf et al., 2010
The Introduction says LC innervation supplies noradrenaline during focused attention, and the Discussion links the LC to sustained arousal under novel conditions. But the paper does not establish that evaluating a stimulus as rewarding or salient maintains a phasic mode through frequent firing bursts and NE release; its rat experiments concern wakefulness in a novel environment. (LLM, conf=0.84)
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- Authors
- Gompf, H. S., Mathai, C., Fuller, P. M., Wood, D. A., Pedersen, N. P., Saper, C. B., & Lu, J.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-10-27
- Volume
- 30
- Issue
- 43
- Pages
- 14543-14551
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2989851
- OpenAlex
- W2064376850
- Cited by
- 176
- References
- 44
- Citations by year
- 2026: 3 · 2025: 17 · 2024: 14 · 2023: 10 · 2022: 12 · 2021: 15 · 2020: 12 · 2019: 14 · 2018: 16 · 2017: 12 · 2016: 10 · 2015: 7 · 2014: 10 · 2013: 9 · 2012: 7
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG000222, T32AG000222)
- National Heart, Lung, and Blood Institute (P01HL095491, HL060292, P50HL060292)
- National Institute of Neurological Disorders and Stroke (R01NS062727, NS051609, R01NS051609, R01NS061841)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- locus coeruleus, anterior cingulate cortex, wakefulness, arousal, novel environment, social interaction, chemical lesions, ibotenic acid, noradrenergic terminals, sustained attention, EEG arousal
- MeSH terms
- Animals, Arousal, Cell Count, Cerebral Cortex, Data Interpretation, Statistical, Electroencephalography, Electromyography, Environment, Ibotenic Acid, Immunohistochemistry, Interpersonal Relations, Locus Coeruleus, Male, Sleep, Sleep, REM, Tyrosine 3-Monooxygenase, Wakefulness, Proto-Oncogene Proteins c-fos, Rats, Sprague-Dawley, Excitatory Amino Acid Agonists, Rats
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