Temporal Dynamics of Parvalbumin-Expressing Axo-axonic and Basket Cells in the Rat Medial Prefrontal Cortex In Vivo
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Axo-axonic interneurons, innervating exclusively axon initial segments, and parvalbumin-expressing basket interneurons, targeting somata, dendrites, and spines of pyramidal cells, have been proposed to control neuronal activity in prefrontal circuits. We recorded the spike-timing of identified neurons in the prelimbic cortex of anesthetized rats, and show that axo-axonic cells increase their firing during tail pinch-induced brain state-activation. In addition, axo-axonic cells differ from other GABAergic parvalbumin-expressing cells in their spike timing during DOWN- to UP-state transitions of slow oscillations and in their coupling to gamma and spindle oscillations. The distinct firing dynamics and synaptic targets of axo-axonic and other parvalbumin-expressing cells provide differential contributions to the temporal organization of prefrontal networks.
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Some reports found different excitatory input sources and in vivo responses between PV FS basket and chandelier interneurons.
“some reports have found different excitatory input sources and in vivo responses between PV FS basket and chandelier INs”
From GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits (2016) · cites this paper as Massi et al., 2012
The Discussion (page unavailable) reports different in vivo firing dynamics for PV-expressing axo-axonic (chandelier) and basket cells, and the Results describe different responses to tail pinch. The Discussion infers differences in their synaptic inputs from anatomy, but does not establish different excitatory input sources for the two cell types; its suggestion about thalamic and cortical sources concerns basket-cell firing across oscillation states. (LLM, conf=0.86)
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- Authors
- Massi, L., Lagler, M., Hartwich, K., Borhegyi, Z., Somogyi, P., & Klausberger, T.
- Affiliations
- University of Oxford (GB)
- Medical University of Vienna (AT)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-11-14
- Volume
- 32
- Issue
- 46
- Pages
- 16496-16502
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC4487822
- OpenAlex
- W2068933082
- Cited by
- 88
- References
- 31
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 8 · 2022: 3 · 2021: 8 · 2020: 3 · 2019: 5 · 2018: 8 · 2017: 11 · 2016: 10 · 2015: 9 · 2014: 7 · 2013: 8
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vienna Science and Technology Fund (W1205, SCIC03)
- Austrian Science Fund (W1205)
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- basket cells, parvalbumin, medial prefrontal cortex, prelimbic cortex, spike timing, slow oscillations, gamma oscillations, spindle oscillations, brain state transitions, GABAergic interneurons, axon initial segment, in vivo electrophysiology
- MeSH terms
- Animals, Axons, Dendrites, Evoked Potentials, Immunohistochemistry, Interneurons, Nerve Net, Parvalbumins, Physical Stimulation, Rats, Sprague-Dawley, Prefrontal Cortex, Pyramidal Cells, Rats, Electrophysiological Phenomena
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