Short- and Long-Lasting Consequences of In Vivo Nicotine Treatment on Hippocampal Excitability
Open accessAbstract
The potential for relapse following cessation of drug use can last for years, implying the induction of stable changes in neural circuitry. In hippocampal slices from rats treated with nicotine for 1 week, withdrawal from nicotine in vivo produces an increase in CA1 pyramidal cell excitability that persists up to 9 months. Immediately upon drug cessation, the enhanced excitability depends on input from regions upstream of CA1, while the long-term excitability change (> 4 weeks) is expressed as an increase in the intrinsic excitability of CA1 neurons. Re-exposure to nicotine in vitro restores hippocampal function to control levels via activation of high-affinity nicotinic acetylcholine receptors after 1 d of withdrawal, but not at times >4 weeks. Thus, nicotine in vivo first induces homeostatic adaptations followed by other more robust neural changes. These mechanisms may contribute to hippocampal localized cue-motivated reinstatement of drug-seeking and/or cognitive deficits observed during withdrawal.
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Increased excitability in CA1 pyramidal neurons persists even after prolonged withdrawal (24 h-9 months).
“increased excitability in CA1 pyramidal neurons persists even after prolonged withdrawal (24 h–9 months) (Penton et al, 2011).”
From Divergent Functional Effects of Sazetidine-A and Varenicline During Nicotine Withdrawal (2013) · cites this paper as Penton et al, 2011
Nicotine withdrawal is associated with a persistent increase in hippocampal CA1 pyramidal cell activity.
“nicotine withdrawal was associated with a persistent increase in hippocampal CA1pyramidal cell activity (Penton et al., 2011).”
From The duration of nicotine withdrawal-associated deficits in contextual fear conditioning parallels changes in hippocampal high affinity nicotinic acetylcholine receptor upregulation (2012) · cites this paper as Penton et al., 2011
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- Authors
- Penton, R. E., Quick, M. W., & Lester, R. A. J.
- Affiliations
- University of Alabama at Birmingham (US)
- University of Southern California (US)
- Corresponding author
- Lester, Robin A. J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-02-16
- Volume
- 31
- Issue
- 7
- Pages
- 2584-2594
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3095819
- OpenAlex
- W2068450918
- Cited by
- 19
- References
- 77
- Citations by year
- 2026: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2017: 1 · 2014: 3 · 2013: 3 · 2012: 3
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Drug Abuse (DA-11940, R01DA011940)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Keywords
- nicotine, nicotine withdrawal, hippocampus, CA1 pyramidal neurons, neuronal excitability, intrinsic excitability, nicotinic acetylcholine receptors, homeostatic adaptation, relapse, drug-seeking behavior, cognitive impairment, long-term drug effects
- MeSH terms
- Action Potentials, Animals, Dihydro-beta-Erythroidine, Dose-Response Relationship, Drug, Drug Administration Schedule, Electric Stimulation, Hippocampus, Male, Nicotine, Tetrodotoxin, Time Factors, 2-Amino-5-phosphonovalerate, Rats, Sprague-Dawley, Patch-Clamp Techniques, Excitatory Amino Acid Antagonists, Nicotinic Agonists, 6-Cyano-7-nitroquinoxaline-2,3-dione, Excitatory Postsynaptic Potentials, Sodium Channel Blockers, Rats, In Vitro Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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