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Distances between Real-World Locations Are Represented in the Human Hippocampus
Open accessAbstract
Spatial navigation is believed to be guided in part by reference to an internal map of the environment. We used functional magnetic resonance imaging (fMRI) to test for a key aspect of a cognitive map: preservation of real-world distance relationships. University students were scanned while viewing photographs of familiar campus landmarks. fMRI response levels in the left hippocampus corresponded to real-world distances between landmarks shown on successive trials, indicating that this region considered closer landmarks to be more representationally similar and more distant landmarks to be more representationally distinct. In contrast, posterior visually responsive regions such as retrosplenial complex and the parahippocampal place area were sensitive to landmark repetition and encoded landmark identity in their multivoxel activity patterns but did not show a distance-related response. These data suggest the existence of a map-like representation in the human medial temporal lobe that encodes the coordinates of familiar locations in large-scale, real-world environments.
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“it is involved in coding information about the coarse location of objects (Evensmoen et al., 2014), the global position of landmarks (Ekstrom et al., 2011; Morgan et al., 2011), and the gist of memories (Poppenk et al., 2008; Gutchess and Schacter, 2012).”
From Delay-dependent contributions of medial temporal lobe regions to episodic memory retrieval (2015) · cites this paper as Morgan et al., 2011
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Metadata
- Authors
- Morgan, L. K., MacEvoy, S. P., Aguirre, G. K., & Epstein, R. A.
- Affiliations
- Boston College (US)
- University of Pennsylvania (US)
- Corresponding author
- Epstein, Russell A.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-01-26
- Volume
- 31
- Issue
- 4
- Pages
- 1238-1245
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3074276
- OpenAlex
- W2088847426
- Cited by
- 203
- References
- 57
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 10 · 2023: 14 · 2022: 11 · 2021: 19 · 2020: 13 · 2019: 11 · 2018: 16 · 2017: 9 · 2016: 15 · 2015: 17 · 2014: 15 · 2013: 19 · 2012: 15
- FWCI
- 8.27
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (0541957)
- National Eye Institute (EY016464, R01EY016464)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Spatial Cognition and Navigation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- hippocampus, spatial navigation, cognitive maps, medial temporal lobe, parahippocampal place area, retrosplenial complex, spatial representation
- MeSH terms
- Brain Mapping, Distance Perception, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Photic Stimulation, Young Adult
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