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Cited by 258Spatial Cognition and NavigationMemory and Neural MechanismsMemory Processes and Influences

“I have often walked down this street before”: fMRI Studies on the hippocampus and other structures during mental navigation of an old environment

Rosenbaum, R. Shayna, Ziegler, Marilyne, Winocur, Gordon, Grady, Cheryl L., Moscovitch, Morris·2004·Hippocampus
DOI 10.1002/hipo.10218
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Abstract

The role of the hippocampus in recent spatial memory has been well documented in patients with damage to this structure, but there is now evidence that the hippocampus may not be needed for the storage and recovery of a spatial layout that was experienced long before injury. Such preservation may rely, instead, on a network of dissociable, extra‐hippocampal regions implicated in topographical orientation. Using functional magnetic resonance imaging (fMRI), we investigated this hypothesis in healthy individuals with extensive experience navigating in a large‐scale urban environment (downtown Toronto). Participants were scanned as they performed mental navigation tasks that emphasized different types of spatial representations. Tasks included proximity judgments, distance judgments, landmark sequencing, and blocked‐route problem‐solving. The following regions were engaged to varying degrees depending on the processing demands of each task: retrosplenial cortex, believed to be involved in assigning directional significance to locales within a relatively allocentric framework; medial and posterior parietal cortex, concerned with processing space within egocentric coordinates during imagined movement; and regions of prefrontal cortex, present in tasks heavily dependent on working memory. In a second, event‐related experiment, a distinct area of inferotemporal cortex was revealed during identification of familiar landmarks relative to unknown buildings in addition to activation of many of those regions identified in the navigation tasks. This result suggests that familiar landmarks are strongly integrated with the spatial context in which they were experienced. Importantly, right medial temporal lobe activity was observed, its magnitude equivalent across all tasks, though the core of the activated region was in the parahippocampal gyrus, barely touching the hippocampus proper. © 2004 Wiley‐Liss, Inc.

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66 of 66 references verified0 citation errors · 0 not checkable

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  • Schematized spatial memories primarily include geometric properties rather than surface properties.

    “Schematized spatial memories primarily include geometric properties [G], rather than surface properties [G] 27,70,80,83 .”

    From From cognitive maps to spatial schemas (2023) · cites this paper as [83]

  • Many of the same extra-HPC regions involved in the initial acquisition of spatial knowledge for large-scale environments are also involved in the retrieval of schematized spatial memory and event schemas, suggesting that the core elements of spatial schemas may be laid down at acquisition.

    “fMRI studies indicate that many of the same extra-HPC regions involved in the initial acquisition of spatial knowledge for large-scale environments are also involved in the retrieval of schematized spatial memory 27,83,128 and event schemas 22 , suggesting that the core elements of spatial schemas may be laid down at acquisition 92,[147][148][149][150] .”

    From From cognitive maps to spatial schemas (2023) · cites this paper as [83]

  • Candidate neocortical regions for coding such information include the retrosplenial cortex, parahippocampal cortex, and anterior cingulate cortex.

    “Candidate neocortical regions include the retrosplenial cortex (Takahashi et al. 1997; Epstein et al. 2007), parahippocampal cortex (Rosenbaum et al. 2004; Bohbot et al. (2015), for extensive reviews see Spiers and Maguire 2007b; Epstein 2008; Ranganath and Ritchey 2012; Miller et al. 2014), and the anterior cingulate cortex (Teixeira et al. 2006).”

    From Hippocampal and Retrosplenial Goal Distance Coding After Long-term Consolidation of a Real-World Environment (2019) · cites this paper as Rosenbaum et al. 2004

  • Another prior fMRI study involving residents of Toronto mentally navigating this city found no increased activity in the hippocampus.

    “The other study involved residents of Toronto mentally navigating this city and found no increased activity in the hippocampus (Rosenbaum et al. 2004).”

    From Hippocampal and Retrosplenial Goal Distance Coding After Long-term Consolidation of a Real-World Environment (2019) · cites this paper as Rosenbaum et al. 2004

  • RSC response is increased when subjects retrieve spatial information, perform JRD tasks from memory, or move through an environment for which they have obtained survey knowledge.

    “Moreover, its response is increased when subjects retrieve spatial information25, 26, perform JRD tasks from memory27, or move through an environment for which they have obtained survey knowledge28.”

    From Anchoring the neural compass: coding of local spatial reference frames in human medial parietal lobe (2014) · cites this paper as [26]

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Authors
Rosenbaum, R. S., Ziegler, M., Winocur, G., Grady, C. L., & Moscovitch, M.
Affiliations
University of Toronto (CA)
Corresponding author
Rosenbaum, R. Shayna
ORCID
Venue
Hippocampus
Publisher
Wiley
Published
2004-01
Volume
14
Issue
7
Pages
826-835
ISSN
  • 1050-9631 (ISSN-L)
  • 1098-1063
DOI
10.1002/hipo.10218
OpenAlex
W2099695558
Cited by
258
References
66
Citations by year
2026: 6 · 2025: 8 · 2024: 7 · 2023: 9 · 2022: 3 · 2021: 11 · 2020: 10 · 2019: 13 · 2018: 14 · 2017: 16 · 2016: 8 · 2015: 13 · 2014: 13 · 2013: 23 · 2012: 17
FWCI
39.34
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 97 d)
Locations
  • Hippocampus (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research
Topics
  • Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
mental navigation, spatial memory, inferotemporal cortex, parahippocampal gyrus, retrosplenial cortex, parietal cortex, prefrontal cortex, working memory, landmark detection, urban navigation
MeSH terms
Adult, Data Interpretation, Statistical, Evoked Potentials, Hippocampus, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Memory, Orientation, Space Perception

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