Decoding Neuronal Ensembles in the Human Hippocampus
Open accessAbstract
BACKGROUND: The hippocampus underpins our ability to navigate, to form and recollect memories, and to imagine future experiences. How activity across millions of hippocampal neurons supports these functions is a fundamental question in neuroscience, wherein the size, sparseness, and organization of the hippocampal neural code are debated. RESULTS: Here, by using multivariate pattern classification and high spatial resolution functional MRI, we decoded activity across the population of neurons in the human medial temporal lobe while participants navigated in a virtual reality environment. Remarkably, we could accurately predict the position of an individual within this environment solely from the pattern of activity in his hippocampus even when visual input and task were held constant. Moreover, we observed a dissociation between responses in the hippocampus and parahippocampal gyrus, suggesting that they play differing roles in navigation. CONCLUSIONS: These results show that highly abstracted representations of space are expressed in the human hippocampus. Furthermore, our findings have implications for understanding the hippocampal population code and suggest that, contrary to current consensus, neuronal ensembles representing place memories must be large and have an anisotropic structure.
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Recent work has observed similar spatial codes in these regions in humans.
“recent work has observed similar spatial codes in these regions in humans4–8”
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- Authors
- Hassabis, D., Chu, C., Rees, G., Weiskopf, N., Molyneux, P. D., & Maguire, E. A.
- Affiliations
- Wellcome Centre for Human Neuroimaging (GB)
- Corresponding author
- Hassabis, Demis
- Maguire, Eleanor A.
- Venue
- Current Biology
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 19
- Issue
- 7
- Pages
- 546-554
- ISSN
- 0960-9822 (ISSN-L)
- PMC
- PMC2670980
- OpenAlex
- W2073854913
- Cited by
- 231
- References
- 50
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 6 · 2023: 8 · 2022: 8 · 2021: 12 · 2020: 5 · 2019: 11 · 2018: 12 · 2017: 12 · 2016: 7 · 2015: 17 · 2014: 16 · 2013: 28 · 2012: 16
- FWCI
- 12.30
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Current Biology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (084218, 082334)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Physical Sciences › Engineering › Automotive Engineering › Spatial Cognition and Navigation
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- hippocampus, neuronal ensembles, population coding, place memory, spatial navigation, parahippocampal gyrus, virtual reality navigation, multivariate pattern classification, medial temporal lobe
- MeSH terms
- Action Potentials, Adult, Hippocampus, Humans, Magnetic Resonance Imaging, Motor Activity, Nerve Net, Synaptic Transmission, Neurons, Orientation, Space Perception, Multivariate Analysis, Young Adult
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