Cited by 311Stress Responses and CortisolTreatment of Major DepressionResilience and Mental Health

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Resilience to Chronic Stress Is Mediated by Hippocampal Brain-Derived Neurotrophic Factor

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Taliaz, Dekel, Loya, Assaf, Gersner, Roman, Haramati, Sharon, Chen, Alon, Zangen, Abraham·2011·The Journal of Neuroscience

DOI 10.1523/jneurosci.5725-10.2011PMC PMC6622886

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Abstract

Chronic stress is a trigger for several psychiatric disorders, including depression; however, critical individual differences in resilience to both the behavioral and the neurochemical effects of stress have been reported. A prominent mechanism by which the brain reacts to acute and chronic stress is activation of the hypothalamic–pituitary–adrenal (HPA) axis, which is inhibited by the hippocampus via a polysynaptic circuit. Alterations in secretion of stress hormones and levels of brain-derived neurotrophic factor (BDNF) in the hippocampus were implicated in depression and the effects of antidepressant medications. However, the potential role of hippocampal BDNF in behavioral resilience to chronic stress and in the regulation of the HPA axis has not been evaluated. In the present study, Sprague Dawley rats were subjected to 4 weeks of chronic mild stress (CMS) to induce depressive-like behaviors after lentiviral vectors were used to induce localized BDNF overexpression or knockdown in the hippocampus. The behavioral outcome was measured during 3 weeks after the CMS procedure, then plasma samples were taken for measurements of corticosterone levels, and finally hippocampal tissue was taken for BDNF measurements. We found that hippocampal BDNF expression plays a critical role in resilience to chronic stress and that reduction of hippocampal BDNF expression in young, but not adult, rats induces prolonged elevations in corticosterone secretion. The present study describes a mechanism for individual differences in responses to chronic stress and implicates hippocampal BDNF in the development of neural circuits that control adequate stress adaptations.

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Authors: Taliaz, D., Loya, A., Gersner, R., Haramati, S., Chen, A., & Zangen, A.
Affiliations: Weizmann Institute of Science (IL)
Corresponding author: Zangen, Abraham
ORCID: Taliaz, Dekel
Gersner, Roman
Haramati, Sharon
Chen, Alon
Zangen, Abraham
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2011-03-23
Volume: 31
Issue: 12
Pages: 4475-4483
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.5725-10.2011
PMC: PMC6622886
OpenAlex: W1965232611
Cited by: 311
References: 31
Citations by year: 2026: 10 · 2025: 14 · 2024: 12 · 2023: 32 · 2022: 21 · 2021: 20 · 2020: 16 · 2019: 27 · 2018: 21 · 2017: 21 · 2016: 17 · 2015: 29 · 2014: 19 · 2013: 20 · 2012: 22
FWCI: 8.74
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Israel Science Foundation (1486/10)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
Keywords: chronic stress, resilience, hippocampus, brain-derived neurotrophic factor, chronic mild stress, depression, hypothalamic-pituitary-adrenal axis, corticosterone, BDNF overexpression, individual differences, stress adaptation, lentiviral vectors
MeSH terms: Aging, Animals, Chronic Disease, Corticosterone, Environment, Enzyme-Linked Immunosorbent Assay, Exploratory Behavior, Hippocampus, Hydrocortisone, Hypothalamo-Hypophyseal System, Locomotion, Male, Microinjections, Molecular Sequence Data, Pituitary-Adrenal System, Stress, Psychological, Swimming, Rats, Sprague-Dawley, Brain-Derived Neurotrophic Factor, Reverse Transcriptase Polymerase Chain Reaction, Rats, Resilience, Psychological, Gene Knockdown Techniques

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Resilience to Chronic Stress Is Mediated by Hippocampal Brain-Derived Neurotrophic Factor

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