Cited by 147Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Postsynaptic Mechanisms Govern the Differential Excitation of Cortical Neurons by Thalamic Inputs

Open access

Hull, C., Isaacson, J. S., Scanziani, M.·2009·Journal of Neuroscience

DOI 10.1523/jneurosci.5971-08.2009PMC PMC2753516

Open this paper in CoChat — free account Open PDF

Abstract

Thalamocortical (TC) afferents relay sensory input to the cortex by making synapses onto both excitatory regular-spiking principal cells (RS cells) and inhibitory fast-spiking interneurons (FS cells). This divergence plays a crucial role in coordinating excitation with inhibition during the earliest steps of somatosensory processing in the cortex. Although the same TC afferents contact both FS and RS cells, FS cells receive larger and faster excitatory inputs from individual TC afferents. Here, we show that this larger thalamic excitation of FS cells occurs via GluR2-lacking AMPA receptors (AMPARs), and results from a fourfold larger quantal amplitude compared with the thalamic inputs onto RS cells. Thalamic afferents also activate NMDA receptors (NMDARs) at synapses onto both cells types, yet RS cell NMDAR currents are slower and pass more current at physiological membrane potentials. Because of these synaptic specializations, GluR2-lacking AMPARs selectively maintain feedforward inhibition of RS cells, whereas NMDARs contribute to the spiking of RS cells and hence to cortical recurrent excitation. Thus, thalamic afferent activity diverges into two routes that rely on unique complements of postsynaptic AMPARs and NMDARs to orchestrate the dynamic balance of excitation and inhibition as sensory input enters the cortex.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.5971-08.2009

Cites

57 of 57 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex
McCormick, D. A., Connors, B. W., Lighthall, J. W., & Prince, D. A. (1985) · Journal of Neurophysiology · doi:10.1152/jn.1985.54.4.782 · Cited by 1,935
Balanced inhibition underlies tuning and sharpens spike timing in auditory cortex
Wehr, M., & Zador, A. M. (2003) · Nature · doi:10.1038/nature02116 · Cited by 1,405
Two networks of electrically coupled inhibitory neurons in neocortex
Gibson, J. R., Beierlein, M., & Connors, B. W. (1999) · Nature · doi:10.1038/47035 · Cited by 1,404
Relative abundance of subunit mRNAs determines gating and Ca2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS
Geiger, J. R. P., Melcher, T., Koh, D.-S., Sakmann, B., Seeburg, P. H., Jonas, P., & Monyer, H. (1995) · Neuron · doi:10.1016/0896-6273(95)90076-4 · Cited by 1,260
Response properties of vibrissa units in rat SI somatosensory neocortex
Simons, D. J. (1978) · Journal of Neurophysiology · doi:10.1152/jn.1978.41.3.798 · Cited by 780
Functional organization of thalamocortical relays
Sherman, S. M., & Guillery, R. W. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.76.3.1367 · Cited by 762
Cortex is driven by weak but synchronously active thalamocortical synapses
Bruno, R. M., & Sakmann, B. (2006) · Science · doi:10.1126/science.1124593 · Cited by 714
Thalamocortical responses of mouse somatosensory (barrel) cortexin vitro
Agmon, A., & Connors, B. W. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90333-j · Cited by 673
Differences in Ca2+ permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression
Jonas, P. (1994) · Neuron · doi:10.1016/0896-6273(94)90444-8 · Cited by 666
Somatosensory integration controlled by dynamic thalamocortical feed-forward inhibition
Gabernet, L., Jadhav, S. P., Feldman, D. E., Carandini, M., & Scanziani, M. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.022 · Cited by 599
Self-citation

Show all 56 references

Sorted by citations

GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits
Tremblay, R., Lee, S., & Rudy, B. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.033 · Cited by 2,033
“d Fast Ca permeable AMPA receptors containing GluR1flip subunits and lacking GluR2 subunits (Geiger et al., 1995; Hull et al., 2009).”
How Inhibition Shapes Cortical Activity
Isaacson, J. S., & Scanziani, M. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.027 · Cited by 1,678
Self-citation
Synaptic and Behavioral Profile of Multiple Glutamatergic Inputs to the Nucleus Accumbens
Britt, J. P., Benaliouad, F., McDevitt, R. A., Stuber, G. D., Wise, R. A., & Bonci, A. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.040 · Cited by 716
The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors
Lee, S., Hjerling-Leffler, J., Zagha, E., Fishell, G., & Rudy, B. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.1869-10.2010 · Cited by 600
GABAergic interneuron origin of schizophrenia pathophysiology
Nakazawa, K., Zsiros, V., Jiang, Z., Nakao, K., Kolata, S., Zhang, S., & Belforte, J. E. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.01.022 · Cited by 498
Alterations in Cortical Network Oscillations and Parvalbumin Neurons in Schizophrenia
Gonzalez-Burgos, G., Cho, R. Y., & Lewis, D. A. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.010 · Cited by 497
NMDA Receptor Hypofunction, Parvalbumin-Positive Neurons, and Cortical Gamma Oscillations in Schizophrenia
Gonzalez-Burgos, G., & Lewis, D. A. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs010 · Cited by 478
GABAergic Interneurons Shape the Functional Maturation of the Cortex
Le Magueresse, C., & Monyer, H. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.011 · Cited by 425
Distinct functions for direct and transthalamic corticocortical connections
Sherman, S. M., & Guillery, R. W. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00429.2011 · Cited by 336
Alterations of cortical GABA neurons and network oscillations in schizophrenia
Gonzalez-Burgos, G., Hashimoto, T., & Lewis, D. A. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-010-0124-8 · Cited by 260
The mediodorsal thalamus drives feedforward inhibition in the anterior cingulate cortex via parvalbumin interneurons
Delevich, K., Tucciarone, J., Huang, Z. J., & Li, B. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.4565-14.2015 · Cited by 226
Microcircuits of excitatory and inhibitory neurons in layer 2/3 of mouse barrel cortex
Avermann, M., Tomm, C., Matéo, C., Wulfram Gerstner, B., & Petersen, C. C. H. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00917.2011 · Cited by 233
Tasks for inhibitory interneurons in intact brain circuits
Roux, L., & Buzsáki, G. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.09.011 · Cited by 218
Deep molecular diversity of mammalian synapses: why it matters and how to measure it
O'Rourke, N. A., Weiler, N. C., Micheva, K. D., & Smith, S. J. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3170 · Cited by 210
Inhibitory Control of Prefrontal Cortex by the Claustrum
Jackson, J., Karnani, M., Zemelman, B. V., Burdakov, D., & Lee, A. K. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.031 · Cited by 197
Parvalbumin-Expressing Interneurons Linearly Control Olfactory Bulb Output
Kato, H., Gillet, S. N., Peters, A. J., Isaacson, J. S., & Komiyama, T. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.036 · Cited by 186
Self-citation
Synaptic Mechanisms Underlying Strong Reciprocal Connectivity between the Medial Prefrontal Cortex and Basolateral Amygdala
Little, J. P., & Carter, A. G. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2385-13.2013 · Cited by 187
Inhibitory Gating of Basolateral Amygdala Inputs to the Prefrontal Cortex
McGarry, L. M., & Carter, A. G. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.0874-16.2016 · Cited by 169
Nucleus Accumbens Dopamine/Glutamate Interaction Switches Modes to Generate Desire versus Dread: D1Alone for Appetitive Eating But D1and D2Together for Fear
Richard, J. M., & Berridge, K. C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1339-11.2011 · Cited by 158
Glutamate Receptor Subtypes Mediating Synaptic Activation of Prefrontal Cortex Neurons: Relevance for Schizophrenia
Rotaru, D. C., Yoshino, H., Lewis, D. A., Ermentrout, G. B., & Gonzalez-Burgos, G. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1970-10.2011 · Cited by 151
From Dendrite to Soma: Dynamic Routing of Inhibition by Complementary Interneuron Microcircuits in Olfactory Cortex
Stokes, C. C. A., & Isaacson, J. S. (2010) · Neuron · doi:10.1016/j.neuron.2010.06.029 · Cited by 144
Self-citation
Suprachiasmatic VIP neurons are required for normal circadian rhythmicity and comprised of molecularly distinct subpopulations
Todd, W. D., Venner, A., Anaclet, C., Broadhurst, R. Y., Luca, R. D., Bandaru, S. S., Issokson, L., Hablitz, L. M., Cravetchi, O., Arrigoni, E., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17197-2 · Cited by 145
Inhibitory Interneurons and their Circuit Motifs in the Many Layers of the Barrel Cortex
Feldmeyer, D., Qi, G., Emmenegger, V., & Staiger, J. F. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.05.027 · Cited by 141
Rapid Developmental Maturation of Neocortical FS Cell Intrinsic Excitability
Goldberg, E. M., Jeong, H.-Y., Kruglikov, I., Tremblay, R., Lazarenko, R. M., & Rudy, B. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq138 · Cited by 138
Parallel Regulation of Feedforward Inhibition and Excitation during Whisker Map Plasticity
House, D. R. C., Elstrott, J., Koh, E., Chung, J. E., & Feldman, D. E. (2011) · Neuron · doi:10.1016/j.neuron.2011.09.008 · Cited by 108
Recruitment of inhibition and excitation across mouse visual cortex depends on the hierarchy of interconnecting areas
D'Souza, R. D., Meier, A. M., Bista, P., Wang, Q., & Burkhalter, A. (2016) · eLife · doi:10.7554/elife.19332 · Cited by 100
Target-Specific Properties of Thalamocortical Synapses onto Layer 4 of Mouse Primary Visual Cortex
Kloc, M., & Maffei, A. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.2595-14.2014 · Cited by 99
Towards building a more complex view of the lateral geniculate nucleus: Recent advances in understanding its role
Ghodrati, M., Khaligh‐Razavi, S., & Lehky, S. R. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.06.002 · Cited by 106
Distinct Balance of Excitation and Inhibition in an Interareal Feedforward and Feedback Circuit of Mouse Visual Cortex
Yang, W., Carrasquillo, Y., Hooks, B. M., Nerbonne, J. M., & Burkhalter, A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2515-13.2013 · Cited by 99
Target-specific modulation of the descending prefrontal cortex inputs to the dorsal raphe nucleus by cannabinoids
Geddes, S. D., Assadzada, S., Lemelin, D., Sokolovski, A., Bergeron, R., Haj-Dahmane, S., & Béïque, J.-C. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1522754113 · Cited by 90
Altered tactile processing in children with autism spectrum disorder
Tavassoli, T., Bellesheim, K., Tommerdahl, M., Holden, J. M., Kolevzon, A., & Buxbaum, J. D. (2016) · Autism Research · doi:10.1002/aur.1563 · Cited by 88
Emergence of cortical inhibition by coordinated sensory-driven plasticity at distinct synaptic loci
Chittajallu, R., & Isaac, J. T. R. (2010) · Nature Neuroscience · doi:10.1038/nn.2639 · Cited by 85
Multiple clusters of release sites formed by individual thalamic afferents onto cortical interneurons ensure reliable transmission
Bagnall, M. W., Hull, C., Bushong, E. A., Ellisman, M. H., & Scanziani, M. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.032 · Cited by 80
Self-citation
The role of glutamatergic inputs onto parvalbumin-positive interneurons: relevance for schizophrenia
Rotaru, D. C., Lewis, D. A., & González‐Burgos, G. (2012) · Reviews in the Neurosciences · doi:10.1515/revneuro-2011-0059 · Cited by 81
A brain network model explaining tremor in Parkinson's disease
Duval, C., Daneault, J., Hutchison, W. D., & Sadikot, A. F. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.10.009 · Cited by 82
Functional diversity of supragranular GABAergic neurons in the barrel cortex
Gentet, L. J. (2012) · Frontiers in Neural Circuits · doi:10.3389/fncir.2012.00052 · Cited by 83
Activation of Thalamocortical Networks by the N-methyl-D-aspartate Receptor Antagonist Phencyclidine: Reversal by Clozapine
Santana, N., Troyano‐Rodriguez, E., Mengod, G., Celada, P., & Artigas, F. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.10.030 · Cited by 74
Tonic NMDA receptor-mediated current in prefrontal cortical pyramidal cells and fast-spiking interneurons
Povysheva, N. V., & Johnson, J. W. (2012) · Journal of Neurophysiology · doi:10.1152/jn.01017.2011 · Cited by 62
Intracellular, In Vivo , Dynamics of Thalamocortical Synapses in Visual Cortex
Sedigh-Sarvestani, M., Vigeland, L. E., Fernández‐Lamo, I., Taylor, M. M., Palmer, L. A., & Contreras, D. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3370-16.2017 · Cited by 60
Afferent specific role of NMDA receptors for the circuit integration of hippocampal neurogliaform cells
Chittajallu, R., Wester, J. C., Craig, M. T., Barksdale, E., Yuan, X. Q., Akgül, G., Fang, C., Collins, D., Hunt, S., Pelkey, K. A., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00218-y · Cited by 58
Action potential-coupled Rho GTPase signaling drives presynaptic plasticity
Dube, S., Rácz, B., Brown, W. E., Gao, Y., Soderblom, E. J., Yasuda, R., & Soderling, S. H. (2021) · eLife · doi:10.7554/elife.63756 · Cited by 57
Delta oscillation and short-term plasticity in the rat medial prefrontal cortex: modelling NMDA hypofunction of schizophrenia
Kiss, T., Hoffmann, W. E., & Hajós, M. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000271 · Cited by 58
Cell class-specific regulation of neocortical dendrite and spine growth by AMPA receptor splice and editing variants
Hamad, M. I. K., Ma‐Högemeier, Z., Riedel, C., Conrads, C., Veitinger, T., Habijan, T., Schulz, J.-N., Krause, M., Wirth, M. J., Hollmann, M., et al. (2011) · Development · doi:10.1242/dev.071076 · Cited by 55
Sensory experience inversely regulates feedforward and feedback excitation-inhibition ratio in rodent visual cortex
Miska, N. J., Richter, L. M. A., Cary, B. A., Gjorgjieva, J., & Turrigiano, G. G. (2018) · eLife · doi:10.7554/elife.38846 · Cited by 52
Differential Excitation of Distally versus Proximally Targeting Cortical Interneurons by Unitary Thalamocortical Bursts
Hu, H., & Agmon, A. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0739-16.2016 · Cited by 52
Thalamic Drive of Cortical Parvalbumin-Positive Interneurons during Down States in Anesthetized Mice
Zucca, S., Pasquale, V., Roig, P. L. D. L., Panzeri, S., & Fellin, T. (2019) · Current Biology · doi:10.1016/j.cub.2019.04.007 · Cited by 51
Thalamic Burst Firing Propensity: A Comparison of the Dorsal Lateral Geniculate and Pulvinar Nuclei in the Tree Shrew
Wei, H., Bonjean, M., Petry, H. M., B, T. J. S. A., & Bickford, M. E. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6431-10.2011 · Cited by 54
Altered Markers of Cortical γ-Aminobutyric Acid Neuronal Activity in Schizophrenia
Kimoto, S., Zaki, M. M., Bazmi, H. H., & Lewis, D. A. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.0533 · Cited by 53
Synapse‐specific expression of calcium‐permeable AMPA receptors in neocortical layer 5
Lalanne, T., Oyrer, J., Mancino, A. S., Gregor, E., Chung, A. J., Huynh, L., Burwell, S., Maheux, J., Farrant, M., & Sjöström, P. J. (2015) · The Journal of Physiology · doi:10.1113/jp271394 · Cited by 48
Hearing loss differentially affects thalamic drive to two cortical interneuron subtypes
Takesian, A. E., Kotak, V. C., Sharma, N., & Sanes, D. H. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00182.2013 · Cited by 49
Getting Drowsy? Alert/Nonalert Transitions and Visual Thalamocortical Network Dynamics
Bereshpolova, Y., Stoelzel, C. R., Zhuang, J., Amitai, Y., Alonso, J., & Swadlow, H. A. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2262-11.2011 · Cited by 50
Retinal Circuitry Balances Contrast Tuning of Excitation and Inhibition to Enable Reliable Computation of Direction Selectivity
Poleg-Polsky, A., & Diamond, J. S. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4013-15.2016 · Cited by 51
Understanding the molecular diversity of synapses
van Oostrum, M., & Schuman, E. M. (2025) · Nature Reviews Neuroscience · doi:10.1038/s41583-024-00888-w · Cited by 49
Characterization of thalamocortical responses of regular-spiking and fast-spiking neurons of the mouse auditory cortex in vitro and in silico
Schiff, M. L., & Reyes, A. D. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00208.2011 · Cited by 48
Layer 4 in Primary Visual Cortex of the Awake Rabbit: Contrasting Properties of Simple Cells and Putative Feedforward Inhibitory Interneurons
Zhuang, J., Stoelzel, C. R., Bereshpolova, Y., Huff, J. M., Hei, X., Alonso, J., & Swadlow, H. A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.0863-13.2013 · Cited by 47
Layer-Specific Experience-Dependent Rewiring of Thalamocortical Circuits
Wang, L., Kloc, M. L., Gu, Y., Ge, S., & Maffei, A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4423-12.2013 · Cited by 44
NMDA receptor-dependent function and plasticity in inhibitory circuits
Moreau, A. W., & Kullmann, D. M. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.03.004 · Cited by 44
Endogenous GluR1‐containing AMPA receptors translocate to asymmetric synapses in the lateral amygdala during the early phase of fear memory formation: An electron microscopic immunocytochemical study
Nedelescu, H., Kelso, C. M., Lázaro‐Muñoz, G., Purpura, M., Cain, C. K., LeDoux, J. E., & Aoki, C. J. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22472 · Cited by 44
Cocaine Experience Enhances Thalamo-Accumbens N-Methyl-D-Aspartate Receptor Function
Joffe, M. E., & Grueter, B. A. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.04.002 · Cited by 41
Fast activation of feedforward inhibitory neurons from thalamic input and its relevance to the regulation of spike sequences in the barrel cortex
Kimura, F., Itami, C., Ikezoe, K., Tamura, H., Fujita, I., Yanagawa, Y., Obata, K., & Ohshima, M. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.188177 · Cited by 43
Phencyclidine Inhibits the Activity of Thalamic Reticular Gamma-Aminobutyric Acidergic Neurons in Rat Brain
Troyano‐Rodriguez, E., Lladó-Pelfort, L., Santana, N., Teruel‐Martí, V., Celada, P., & Artigas, F. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.05.019 · Cited by 40
Cerebellar Shaping of Motor Cortical Firing Is Correlated with Timing of Motor Actions
Nashef, A., Cohen, O. S., Israel, Z. H., Harel, R., & Prut, Y. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.04.035 · Cited by 40
Mechanisms underlying a thalamocortical transformation during active tactile sensation
Gutnisky, D. A., Yu, J., Hires, S. A., To, M., Bale, M. R., Svoboda, K., & Golomb, D. (2017) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1005576 · Cited by 34
Presynaptic Effects of N-Methyl-D-Aspartate Receptors Enhance Parvalbumin Cell–Mediated Inhibition of Pyramidal Cells in Mouse Prefrontal Cortex
Pafundo, D. E., Miyamae, T., Lewis, D. A., & González‐Burgos, G. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.01.018 · Cited by 37
Alleviation of Neuropathic Pain by Regulating T-Type Calcium Channels in Rat Anterior Cingulate Cortex
Shen, F.-Y., Chen, Z.-Y., Zhong, W., Ma, L., Chen, C., Yang, Z., Xie, W.-L., & Wang, Y. (2015) · Molecular Pain · doi:10.1186/s12990-015-0008-3 · Cited by 37
Neocortical layer 4 as a pluripotent function linearizer
Favorov, O. V., & Kurşun, O. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00708.2010 · Cited by 34
Emerging Mechanisms Underlying Dynamics of GABAergic Synapses
Maffei, A., Charrier, C., Caiati, M. D., Barberis, A., Mahadevan, V., Woodin, M. A., & Tyagarajan, S. K. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1824-17.2017 · Cited by 35
Disruption of thalamocortical activity in schizophrenia models: relevance to antipsychotic drug action
Celada, P., Lladó-Pelfort, L., Santana, N., Kargieman, L., Troyano‐Rodriguez, E., Riga, M. S., & Artigas, F. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145713000643 · Cited by 33
Synaptic Integration in Cortical Inhibitory Neuron Dendrites
Hu, H., & Vervaeke, K. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.06.065 · Cited by 30
Studies of cortical connectivity using optical circuit mapping methods
Anastasiades, P. G., Marques–Smith, A., & Butt, S. J. B. (2017) · The Journal of Physiology · doi:10.1113/jp273463 · Cited by 32
Presynaptic Diversity Revealed by Ca 2+ -Permeable AMPA Receptors at the Calyx of Held Synapse
Lujan, B., Dagostin, A., & von Gersdorff, H. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2565-18.2019 · Cited by 30
Modulation and function of the autaptic connections of layer V fast spiking interneurons in the rat neocortex
Connelly, W. M., & Lees, G. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2009.185199 · Cited by 29
Mutation of the Dyslexia-Associated Gene Dcdc2 Enhances Glutamatergic Synaptic Transmission Between Layer 4 Neurons in Mouse Neocortex
Che, A., Truong, D. T., FITCH, R. H., & LoTurco, J. J. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv168 · Cited by 27
“Silent” NMDA Synapses Enhance Motion Sensitivity in a Mature Retinal Circuit
Sethuramanujam, S., Yao, X., deRosenroll, G., Briggman, K. L., Field, G. D., & Awatramani, G. B. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.058 · Cited by 28
Focal Local Field Potential Signature of the Single-Axon Monosynaptic Thalamocortical Connection
Hagen, E., Fossum, J. C., Pettersen, K. H., Alonso, J., Swadlow, H. A., & Einevoll, G. T. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2715-16.2017 · Cited by 29
Enhanced Thalamocortical Synaptic Transmission and Dysregulation of the Excitatory–Inhibitory Balance at the Thalamocortical Feedforward Inhibitory Microcircuit in a Genetic Mouse Model of Migraine
Tottene, A., Favero, M., & Pietrobon, D. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1840-19.2019 · Cited by 28
Impact of Thalamocortical Input on Barrel Cortex Development
Martini, F. J., Moreno‐Juan, V., Filipchuk, A., Valdeolmillos, M., & López‐Bendito, G. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.04.005 · Cited by 26
Specific mechanism of use-dependent channel block of calcium-permeable AMPA receptors provides activity-dependent inhibition of glutamatergic neurotransmission
Zaitsev, A. V., Kim, K. K., Fedorova, I. M., Dorofeeva, N. A., Magazanik, L. G., & Tikhonov, D. B. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2010.204362 · Cited by 26
Synaptic inhibition in the neocortex: Orchestration and computation through canonical circuits and variations on the theme
Lourenço, J., Koukouli, F., & Bacci, A. (2020) · Cortex · doi:10.1016/j.cortex.2020.08.015 · Cited by 25
An antagonist of calcium permeable AMPA receptors, IEM1460: Anticonvulsant action in immature rats?
Szczurowska, E., & Mareš, P. (2014) · Epilepsy Research · doi:10.1016/j.eplepsyres.2014.10.020 · Cited by 25
Three rules govern thalamocortical connectivity of fast-spike inhibitory interneurons in the visual cortex
Bereshpolova, Y., Hei, X., Alonso, J., & Swadlow, H. A. (2020) · eLife · doi:10.7554/elife.60102 · Cited by 23
Functional properties and short‐term dynamics of unidirectional and reciprocal synaptic connections between layer 2/3 pyramidal cells and fast‐spiking interneurons in juvenile rat prefrontal cortex
Zaitsev, A. V., & Lewis, D. A. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12294 · Cited by 22
Trading Speed and Accuracy by Coding Time: A Coupled-circuit Cortical Model
Standage, D., You, H., Wang, D., & Dorris, M. C. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003021 · Cited by 21
Unique properties of dually innervated dendritic spines in pyramidal neurons of the somatosensory cortex uncovered by 3D correlative light and electron microscopy
Gemin, O., Serna, P., Zamith, J., Assendorp, N., Fossati, M., Rostaing, P., Triller, A., & Charrier, C. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001375 · Cited by 25
A cerebellar origin of feedforward inhibition to the motor cortex in non-human primates
Nashef, A., Cohen, O. S., Perlmutter, S. I., & Prut, Y. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110803 · Cited by 27
Two functional inhibitory circuits are comprised of a heterogeneous population of fast-spiking cortical interneurons
Li, P., & Huntsman, M. M. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.033 · Cited by 20
A model of order-selectivity based on dynamic changes in the balance of excitation and inhibition produced by short-term synaptic plasticity
Goudar, V., & Buonomano, D. V. (2014) · Journal of Neurophysiology · doi:10.1152/jn.00568.2014 · Cited by 21
The Role of Polyamine-Dependent Facilitation of Calcium Permeable AMPARs in Short-Term Synaptic Enhancement
Rozov, A. V., Zakharova, Y., Vazetdinova, A., & Valiullina, F. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00345 · Cited by 19
Map transfer from the thalamus to the neocortex: Inputs from the barrel field
Lokmane, L., & Garel, S. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.07.005 · Cited by 24
Inhibitory Interneuron Classes Express Complementary AMPA-Receptor Patterns in Macaque Primary Visual Cortex
Kooijmans, R. N., Self, M. W., Wouterlood, F. G., Beliën, J. A. M., & Roelfsema, P. R. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3188-13.2014 · Cited by 19
Effects of Low Doses of Ketamine on Pyramidal Neurons in Rat Prefrontal Cortex
Shen, G., Han, F., & Shi, W. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.05.037 · Cited by 18
Input-specific maturation of NMDAR-mediated transmission onto parvalbumin-expressing interneurons in layers 2/3 of the visual cortex
Ferrer, C., Hsieh, H. V., & Wollmuth, L. P. (2018) · Journal of Neurophysiology · doi:10.1152/jn.00495.2018 · Cited by 17
Multiple long-range inputs evoke NMDA currents in prefrontal cortex fast-spiking interneurons
Bogart, L. J., & O’Donnell, P. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0029-5 · Cited by 16
Intrinsic properties of and thalamocortical inputs onto identified corticothalamic-VPM neurons
Yang, Q., Chen, C.-C., Ramos, R. L., Katz, E. J., Keller, A., & Brumberg, J. C. (2014) · Somatosensory & Motor Research · doi:10.3109/08990220.2013.869495 · Cited by 14
Alterations in Prefrontal Cortical Circuitry and Cognitive Dysfunction in Schizophrenia
Lewis, D. A., & Glausier, J. R. (2016) · Nebraska Symposium on Motivation/The Nebraska symposium on motivation · doi:10.1007/978-3-319-30596-7_3 · Cited by 15
The role of voltage dependence of the NMDA receptor in cellular and network oscillation
Martell, A., Ramirez, J., Lasky, R. E., Dwyer, J. E., Kohrman, M. H., & van Drongelen, W. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08083.x · Cited by 13
A kinetic model for the frequency dependence of cholinergic modulation at hippocampal GABAergic synapses
Stone, E. F., Haario, H., & Lawrence, J. J. (2014) · Mathematical Biosciences · doi:10.1016/j.mbs.2014.09.013 · Cited by 11
Pathway-specific contribution of parvalbumin interneuron NMDARs to synaptic currents and thalamocortical feedforward inhibition
Lewis, E. M., Spence, H. E., Akella, N., & Buonanno, A. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01747-9 · Cited by 14
Imbalance of excitation and inhibition at threshold level in the auditory cortex
Zhao, Y., Zhang, Z., Liu, X., Xiong, C., Xiao, Z., & Yan, J. (2015) · Frontiers in Neural Circuits · doi:10.3389/fncir.2015.00011 · Cited by 11
Frequency-dependent gating of feedforward inhibition in thalamofrontal synapses
Lee, J., Choi, J. H., & Rah, J. (2020) · Molecular Brain · doi:10.1186/s13041-020-00608-2 · Cited by 10

Authors: Hull, C., Isaacson, J. S., & Scanziani, M.
Affiliations: University of California San Diego (US)
Corresponding author: Scanziani, M.
ORCID: Hull, C.
Isaacson, J. S.
Scanziani, M.
Venue: Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2009-07-15
Volume: 29
Issue: 28
Pages: 9127-9136
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.5971-08.2009
PMC: PMC2753516
OpenAlex: W2046924947
Cited by: 147
References: 56
Citations by year: 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 6 · 2018: 11 · 2017: 16 · 2016: 10 · 2015: 10 · 2014: 13 · 2013: 14 · 2012: 12
FWCI: 5.96
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (NH70058)
National Institute of Mental Health (R01MH070058)
National Institute of Neurological Disorders and Stroke (F32NS060585)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: thalamocortical afferents, postsynaptic mechanisms, fast-spiking interneurons, NMDA receptor, feedforward inhibition, excitation-inhibition balance, somatosensory processing, synaptic specializations
MeSH terms: Animals, Animals, Newborn, Biophysics, Calcium, Drug Interactions, Electric Stimulation, Mice, Inbred ICR, Neural Inhibition, Neural Pathways, Neurons, Pyridazines, Somatosensory Cortex, Strontium, Synapses, Thalamus, Time Factors, Receptors, N-Methyl-D-Aspartate, Patch-Clamp Techniques, Excitatory Amino Acid Antagonists, GABA Antagonists, Excitatory Postsynaptic Potentials, Principal Component Analysis, Mice, Inhibitory Postsynaptic Potentials, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Postsynaptic Mechanisms Govern the Differential Excitation of Cortical Neurons by Thalamic Inputs

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks