Cited by 385Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesDecision-Making and Behavioral Economics

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Dopaminergic Mechanisms of Individual Differences in Human Effort-Based Decision-Making

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Treadway, Michael T., Buckholtz, Joshua W., Cowan, Ronald L., Woodward, Neil D., Li, Rui, Ansari, M. Sib, Baldwin, Ronald M., Schwartzman, Ashley N., Kessler, Robert M., Zald, David H.·2012·The Journal of Neuroscience

DOI 10.1523/jneurosci.6459-11.2012PMC PMC3391699

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Abstract

Preferences for different combinations of costs and benefits are a key source of variability in economic decision-making. However, the neurochemical basis of individual differences in these preferences is poorly understood. Studies in both animals and humans have demonstrated that direct manipulation of the neurotransmitter dopamine (DA) significantly impacts cost/benefit decision-making, but less is known about how naturally occurring variation in DA systems may relate to individual differences in economic behavior. In the present study, 25 healthy volunteers completed a dual-scan PET imaging protocol with [(18)F]fallypride and d-amphetamine to measure DA responsivity and separately completed the effort expenditure for rewards task, a behavioral measure of cost/benefit decision-making in humans. We found that individual differences in DA function in the left striatum and ventromedial prefrontal cortex were correlated with a willingness to expend greater effort for larger rewards, particularly when probability of reward receipt was low. Additionally, variability in DA responses in the bilateral insula was negatively correlated with willingness to expend effort for rewards, consistent with evidence implicating this region in the processing of response costs. These findings highlight the role of DA signaling in striatal, prefrontal, and insular regions as key neurochemical mechanisms underlying individual differences in cost/benefit decision-making.

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Authors: Treadway, M. T., Buckholtz, J. W., Cowan, R. L., Woodward, N. D., Li, R., Ansari, M. S., Baldwin, R. M., Schwartzman, A. N., Kessler, R. M., & Zald, D. H.
Affiliations: Vanderbilt University (US)
ORCID: Treadway, Michael T.
Buckholtz, Joshua W.
Cowan, Ronald L.
Woodward, Neil D.
Li, Rui
Zald, David H.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2012-05-02
Volume: 32
Issue: 18
Pages: 6170-6176
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.6459-11.2012
PMC: PMC3391699
OpenAlex: W1964544901
Cited by: 385
References: 62
Citations by year: 2026: 23 · 2025: 15 · 2024: 20 · 2023: 19 · 2022: 23 · 2021: 23 · 2020: 29 · 2019: 26 · 2018: 43 · 2017: 32 · 2016: 40 · 2015: 31 · 2014: 26 · 2013: 28 · 2012: 7
FWCI: 12.03
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Journal of Neuroscience Nursing
Funders: National Institute of Mental Health (F31MH087015, R21MH092751)
National Institute on Drug Abuse (R01DA019670)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
Keywords: dopamine, effort-based decision making, individual differences, striatum, ventromedial prefrontal cortex, insula, response cost, reward probability, d-amphetamine, economic decision-making
MeSH terms: Adult, Brain, Cost-Benefit Analysis, Decision Making, Dopamine, Female, Humans, Male, Motivation, Reward, Young Adult, Dopaminergic Neurons

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Dopaminergic Mechanisms of Individual Differences in Human Effort-Based Decision-Making

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