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Dopaminergic Mechanisms of Individual Differences in Human Effort-Based Decision-Making
Open accessAbstract
Preferences for different combinations of costs and benefits are a key source of variability in economic decision-making. However, the neurochemical basis of individual differences in these preferences is poorly understood. Studies in both animals and humans have demonstrated that direct manipulation of the neurotransmitter dopamine (DA) significantly impacts cost/benefit decision-making, but less is known about how naturally occurring variation in DA systems may relate to individual differences in economic behavior. In the present study, 25 healthy volunteers completed a dual-scan PET imaging protocol with [(18)F]fallypride and d-amphetamine to measure DA responsivity and separately completed the effort expenditure for rewards task, a behavioral measure of cost/benefit decision-making in humans. We found that individual differences in DA function in the left striatum and ventromedial prefrontal cortex were correlated with a willingness to expend greater effort for larger rewards, particularly when probability of reward receipt was low. Additionally, variability in DA responses in the bilateral insula was negatively correlated with willingness to expend effort for rewards, consistent with evidence implicating this region in the processing of response costs. These findings highlight the role of DA signaling in striatal, prefrontal, and insular regions as key neurochemical mechanisms underlying individual differences in cost/benefit decision-making.
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“In a PET study of control subjects, Treadway et al (Treadway et al., 2012) showed a positive association between striatal dopamine release (left caudate) and the willingness to expend effort to obtain a larger reward over a smaller reward.”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as Treadway et al., 2012
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Metadata
- Authors
- Treadway, M. T., Buckholtz, J. W., Cowan, R. L., Woodward, N. D., Li, R., Ansari, M. S., Baldwin, R. M., Schwartzman, A. N., Kessler, R. M., & Zald, D. H.
- Affiliations
- Vanderbilt University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-05-02
- Volume
- 32
- Issue
- 18
- Pages
- 6170-6176
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3391699
- OpenAlex
- W1964544901
- Cited by
- 385
- References
- 62
- Citations by year
- 2026: 23 · 2025: 15 · 2024: 20 · 2023: 19 · 2022: 23 · 2021: 23 · 2020: 29 · 2019: 26 · 2018: 43 · 2017: 32 · 2016: 40 · 2015: 31 · 2014: 26 · 2013: 28 · 2012: 7
- FWCI
- 12.03
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Journal of Neuroscience Nursing
- Funders
- National Institute of Mental Health (F31MH087015, R21MH092751)
- National Institute on Drug Abuse (R01DA019670)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Keywords
- dopamine, effort-based decision making, individual differences, striatum, ventromedial prefrontal cortex, insula, response cost, reward probability, d-amphetamine, economic decision-making
- MeSH terms
- Adult, Brain, Cost-Benefit Analysis, Decision Making, Dopamine, Female, Humans, Male, Motivation, Reward, Young Adult, Dopaminergic Neurons
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