Dissociable contributions of anterior cingulate cortex and basolateral amygdala on a rodent cost/benefit decision-making task of cognitive effort

Hosking, Jay G; Cocker, Paul J; Winstanley, Catharine A

doi:10.1038/npp.2014.27

Cited by 119Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorMemory and Neural Mechanisms

Dissociable contributions of anterior cingulate cortex and basolateral amygdala on a rodent cost/benefit decision-making task of cognitive effort

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Hosking, Jay G, Cocker, Paul J, Winstanley, Catharine A·2014·Neuropsychopharmacology

DOI 10.1038/npp.2014.27PMC PMC4023153

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Abstract

Personal success often requires the choice to expend greater effort for larger rewards, and deficits in such effortful decision making accompany a number of illnesses including depression, schizophrenia, and attention-deficit/hyperactivity disorder. Animal models have implicated brain regions such as the basolateral amygdala (BLA) and anterior cingulate cortex (ACC) in physical effort-based choice, but disentangling the unique contributions of these two regions has proven difficult, and effort demands in industrialized society are predominantly cognitive in nature. Here we utilize the rodent cognitive effort task (rCET), a modification of the five-choice serial reaction-time task, wherein animals can choose to expend greater visuospatial attention to obtain larger sucrose rewards. Temporary inactivation (via baclofen-muscimol) of BLA and ACC showed dissociable effects: BLA inactivation caused hard-working rats to 'slack off' and 'slacker' rats to work harder, whereas ACC inactivation caused all animals to reduce willingness to expend mental effort. Furthermore, BLA inactivation increased the time needed to make choices, whereas ACC inactivation increased motor impulsivity. These data illuminate unique contributions of BLA and ACC to effort-based decision making, and imply overlapping yet distinct circuitry for cognitive vs physical effort. Our understanding of effortful decision making may therefore require expanding our models beyond purely physical costs.

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Amygdala and ACC inactivations caused changes to behaviour during a cognitive effort task that were different from those in physical effort tasks.
“Specifically, amygdala and ACC inactivations caused changes to behaviour during a cognitive effort task [27] that were different to those in physical effort tasks [2, 25, 26].”
From Neurocomputational mechanisms underlying subjective valuation of effort costs (2017) · cites this paper as [27]

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Authors: Hosking, J. G., Cocker, P. J., & Winstanley, C. A.
Affiliations: University of British Columbia (CA)
ORCID: Cocker, Paul J
Winstanley, Catharine A
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2014-02-05
Volume: 39
Issue: 7
Pages: 1558-1567
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/npp.2014.27
PMC: PMC4023153
OpenAlex: W1969727558
Cited by: 119
References: 62
Citations by year: 2026: 3 · 2025: 7 · 2024: 8 · 2023: 5 · 2022: 8 · 2021: 9 · 2020: 10 · 2019: 11 · 2018: 15 · 2017: 15 · 2016: 11 · 2015: 11 · 2014: 6
FWCI: 8.00
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychopharmacology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Michael Smith Health Research BC
Canadian Institutes of Health Research
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: effort-based decision making, cognitive effort, anterior cingulate cortex, basolateral amygdala, 5-choice serial reaction time task, muscimol inactivation, baclofen, visuospatial attention, motor impulsivity, depression, schizophrenia, attention deficit hyperactivity disorder
MeSH terms: Animals, Attention, Baclofen, Cognition, Conditioning, Operant, Decision Making, Physical Exertion, Gyrus Cinguli, Humans, Male, Muscimol, Photic Stimulation, Reaction Time, Reward, Space Perception, GABA Agonists, Rats, Long-Evans, Rats, Basolateral Nuclear Complex

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Dissociable contributions of anterior cingulate cortex and basolateral amygdala on a rodent cost/benefit decision-making task of cognitive effort

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