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SIRT2 induces the checkpoint kinase BubR1 to increase lifespan
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Transgenic mice overexpressing the mitotic checkpoint kinase BubR1 exhibit an extended healthy lifespan.
“Conversely, transgenic mice overexpressing the mitotic checkpoint kinase BubR1 exhibit an extended healthy lifespan 13 (Table 1) .”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [13]
Telomerase induction therapies, restorative proteomic therapies, and prevention of genomic instability are emerging technologies that can assist in maintaining youthful tissue function.
“Sophisticated interventions such as telomerase induction therapies, 43 restorative proteomic therapies to rejuvenate tissues, 44 and prevention of genomic instability 45 are among emerging technologies that can assist in maintaining youthful tissue function.”
From Three Tiers to biological escape velocity: The quest to outwit aging (2022) · cites this paper as [44]
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1 retracted
Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats
Braidy, N., Guillemin, G. J., Mansour, H., Chan-Ling, T., Poljak, A., & Grant, R. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019194 · Cited by 594
RetractedClearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 6×
“However, removing senescence cells from these mice was not sufficient to reverse their shortened lifespan, due to their defects in cardiac electrophysiology (Baker et al, 2011).”
BackgroundInfluentialSelf-citationPhosphorylated CREB binds specifically to the nuclear protein CBP
Chrivia, J. C., Kwok, R. P. S., Lamb, N., Hagiwara, M., Montminy, M. R., & Goodman, R. H. (1993) · Nature · doi:10.1038/365855a0 · Cited by 2,052
The sirtuin SIRT6 regulates lifespan in male mice
Kanfi, Y., Naiman, S., Amir, G., Peshti, V., Zinman, G., Nahum, L., Bar-Joseph, Z., & Cohen, H. Y. (2012) · Nature · doi:10.1038/nature10815 · Cited by 1,059
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
Baker, D. J., Jeganathan, K. B., Cameron, J. D., Thompson, M., Juneja, S., Kopecka, A., Kumar, R., Jenkins, R. B., de Groen, P. C., Roche, P., et al. (2004) · Nature Genetics · doi:10.1038/ng1382 · Cited by 731
Self-citationSirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice
Boily, G., Seifert, E. L., Bevilacqua, L., He, X. H., Sabourin, G., Estey, C., Moffat, C., Crawford, S., Saliba, S., Jardine, K., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001759 · Cited by 444
Increase in Activity During Calorie Restriction Requires Sirt1
Chen, D., Steele, A. D., Lindquist, S., & Guarente, L. (2005) · Science · doi:10.1126/science.1118357 · Cited by 419
Flagged first, then by citations
Research works printed but not linked: 44
- Bachman S, Sparrow D, Smith LK (1981) Effect of aging on the electrocardiogram. Am J Cardiol 48: 513–516 · DOI
- Baker DJ, Dawlaty MM, Wijshake T, Jeganathan KB, Malureanu L, van Ree JH, Crespo‐Diaz R, Reyes S, Seaburg L, Shapiro V, Behfar A, Terzic A, van de Sluis B, van Deursen JM (2013) Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nat Cell Biol 15: 96–102 · DOI · Paper page
- Beard C, Hochedlinger K, Plath K, Wutz A, Jaenisch R (2006) Efficient method to generate single‐copy transgenic mice by site‐specific integration in embryonic stem cells. Genesis 44: 23–28 · DOI
- Cohen HY, Lavu S, Bitterman KJ, Hekking B, Imahiyerobo TA, Miller C, Frye R, Ploegh H, Kessler BM, Sinclair DA (2004a) Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax‐mediated apoptosis. Mol Cell 13: 627–638 · DOI
- Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA (2004b) Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 305: 390–392 · DOI · Paper page
- Davenport JW, Fernandes ER, Harris LD, Neale GA, Goorha R (1999) The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle‐dependent manner. Genomics 55: 113–117 · DOI
- Du XJ (2004) Gender modulates cardiac phenotype development in genetically modified mice. Cardiovasc Res 63: 510–519 · DOI
- Elowe S (2011) Bub1 and BubR1: at the interface between chromosome attachment and the spindle checkpoint. Mol Cell Biol 31: 3085–3093 · DOI
- Eskandarian HA, Impens F, Nahori MA, Soubigou G, Coppee JY, Cossart P, Hamon MA (2013) A role for SIRT2‐dependent histone H3K18 deacetylation in bacterial infection. Science 341: 1238858 · DOI
- Garcia‐Castillo H, Vasquez‐Velasquez AI, Rivera H, Barros‐Nunez P (2008) Clinical and genetic heterogeneity in patients with mosaic variegated aneuploidy: delineation of clinical subtypes. Am J Med Genet A 146A: 1687–1695 · DOI
- Gussak I, Bjerregaard P, Egan TM, Chaitman BR (1995) ECG phenomenon called the J wave. History, pathophysiology, and clinical significance. J Electrocardiol 28: 49–58 · DOI
- Haigis MC, Sinclair DA (2010) Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol 5: 253–295 · DOI · Paper page
- Inoue T, Hiratsuka M, Osaki M, Oshimura M (2007) The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation. Cell Cycle 6: 1011–1018 · DOI
- Izumi H, Matsumoto Y, Ikeuchi T, Saya H, Kajii T, Matsuura S (2009) BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells. Oncogene 28: 2806–2820 · DOI
- Jacquemont S, Boceno M, Rival JM, Mechinaud F, David A (2002) High risk of malignancy in mosaic variegated aneuploidy syndrome. Am J Med Genet 109: 17–21; discussion 16 · DOI
- Jing E, Gesta S, Kahn CR (2007) SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metab 6: 105–114 · DOI
- Kim HS, Vassilopoulos A, Wang RH, Lahusen T, Xiao Z, Xu X, Li C, Veenstra TD, Li B, Yu H, Ji J, Wang XW, Park SH, Cha YI, Gius D, Deng CX (2011) SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity. Cancer Cell 20: 487–499 · DOI
- Krishan A (1975) Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. J Cell Biol 66: 188–193 · DOI
- Lane AH, Aijaz N, Galvin‐Parton P, Lanman J, Mangano R, Wilson TA (2002) Mosaic variegated aneuploidy with growth hormone deficiency and congenital heart defects. Am J Med Genet 110: 273–277 · DOI
- Lerin C, Rodgers JT, Kalume DE, Kim SH, Pandey A, Puigserver P (2006) GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC‐1alpha. Cell Metab 3: 429–438 · DOI · Paper page
- Liu J, Rigel DF (2009) Echocardiographic examination in rats and mice. Methods Mol Biol 573: 139–155 · DOI
- Nateri AS, Riera‐Sans L, Da Costa C, Behrens A (2004) The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling. Science 303: 1374–1378 · DOI
- North BJ, Verdin E (2004) Sirtuins: Sir2‐related NAD‐dependent protein deacetylases. Genome Biol 5: 224 · DOI
- North BJ, Verdin E (2007a) Interphase nucleo‐cytoplasmic shuttling and localization of SIRT2 during mitosis. PLoS One 2: e784 · DOI
- North BJ, Verdin E (2007b) Mitotic regulation of SIRT2 by cyclin‐dependent kinase 1‐dependent phosphorylation. J Biol Chem 282: 19546–19555 · DOI
- North BJ, Marshall BL, Borra MT, Denu JM, Verdin E (2003) The human Sir2 ortholog, SIRT2, is an NAD+‐dependent tubulin deacetylase. Mol Cell 11: 437–444 · DOI
- Oberg C, Li J, Pauley A, Wolf E, Gurney M, Lendahl U (2001) The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel‐10 homolog. J Biol Chem 276: 35847–35853 · DOI
- Peng J, Gygi SP (2001) Proteomics: the move to mixtures. J Mass Spectrom 36: 1083–1091 · DOI
- Price NL, Gomes AP, Ling AJ, Duarte FV, Martin‐Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, Moaddel R, Rolo AP, Coppari R, Palmeira CM, de Cabo R et al (2012) SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab 15: 675–690 · DOI · Paper page
- Sauve AA, Schramm VL (2003) Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry. Biochemistry 42: 9249–9256 · DOI
- Schwer B, North BJ, Frye RA, Ott M, Verdin E (2002) The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide‐dependent deacetylase. J Cell Biol 158: 647–657 · DOI
- Serrano L, Martinez‐Redondo P, Marazuela‐Duque A, Vazquez BN, Dooley SJ, Voigt P, Beck DB, Kane‐Goldsmith N, Tong Q, Rabanal RM, Fondevila D, Munoz P, Kruger M, Tischfield JA, Vaquero A (2013) The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation. Genes Dev 27: 639–653 · DOI
- Shevchenko A, Wilm M, Vorm O, Mann M (1996) Mass spectrometric sequencing of proteins silver‐stained polyacrylamide gels. Anal Chem 68: 850–858 · DOI
- Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C, Tanokura M, Denu JM, Prolla TA (2010) Sirt3 mediates reduction of oxidative damage and prevention of age‐related hearing loss under caloric restriction. Cell 143: 802–812 · DOI · Paper page
- Song J, Ke SF, Zhou CC, Zhang SL, Guan YF, Xu TY, Sheng CQ, Wang P, Miao CY (2013) Nicotinamide phosphoribosyltransferase is required for the calorie restriction‐mediated improvements in oxidative stress, mitochondrial biogenesis, and metabolic adaptation. J Gerontol A Biol Sci Med Sci 69: 44–57 · DOI
- Surawicz B, Parikh SR (2003) Differences between ventricular repolarization in men and women: description, mechanism and implications. Ann Noninvasive Electrocardiol 8: 333–340 · DOI
- Tang Z, Shu H, Oncel D, Chen S, Yu H (2004) Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint. Mol Cell 16: 387–397 · DOI
- Vaquero A, Scher MB, Lee DH, Sutton A, Cheng HL, Alt FW, Serrano L, Sternglanz R, Reinberg D (2006) SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev 20: 1256–1261 · DOI
- Wang F, Nguyen M, Qin FX, Tong Q (2007) SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 6: 505–514 · DOI
- Wei W, Jin J, Schlisio S, Harper JW, Kaelin WG Jr (2005) The v‐Jun point mutation allows c‐Jun to escape GSK3‐dependent recognition and destruction by the Fbw7 ubiquitin ligase. Cancer Cell 8: 25–33 · DOI · Paper page
- Xu J (2005) Preparation, culture, and immortalization of mouse embryonic fibroblasts. In Current Protocols in Molecular Biology, Ausubel FM et al (eds), Chapter 28: Unit 28 21. New York: Wiley and Sons
- Yang XJ, Ogryzko VV, Nishikawa J, Howard BH, Nakatani Y (1996) A p300/CBP‐associated factor that competes with the adenoviral oncoprotein E1A. Nature 382: 319–324 · DOI
- Yoshino J, Mills KF, Yoon MJ, Imai S (2011) Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet‐ and age‐induced diabetes in mice. Cell Metab 14: 528–536 · DOI · Paper page
- Zheng ZJ, Croft JB, Giles WH, Mensah GA (2001) Sudden cardiac death in the United States, 1989 to 1998. Circulation 104: 2158–2163 · DOI
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Metadata
- Authors
- North, B. J., Rosenberg, M. A., Jeganathan, K. B., Hafner, A. V., Michan, S., Dai, J., Baker, D. J., Cen, Y., Wu, L. E., Sauve, A. A., van Deursen, J. M., Rosenzweig, A., & Sinclair, D. A.
- Venue
- The EMBO Journal
- Published
- 2014-05-13
- Volume
- 33
- Issue
- 13
- Pages
- 1438-1453
- ISSN
- 0261-4189
- 1460-2075
- Cited by
- 238
- References
- 7
- Language
- en
- Funders
- NIH/NIA (R01 AG028730, RO1 AG019719)
- Glenn Foundation for Medical Research
- United Mitochondrial Disease Foundation
- The Juvenile Diabetes foundation
- BIDMC/Harvard Translational Research (T32 AG023480)
- NIH
- Leducq Foundation Network of Research Excellence
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