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Cited by 465

The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.

EMT, CTCs and CSCs in tumor relapse and drug-resistance

Open access
Mitra, Abhisek, Mishra, Lopa, Li, Shulin·2015·Oncotarget
DOI 10.18632/oncotarget.4037
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Abstract

// Abhisek Mitra 1 , Lopa Mishra 2 and Shulin Li 1 1 Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA 2 Department of Gastroenterology, Hepatology and Nutrition, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Correspondence to: Shulin Li, email: // Keywords : tumor relapse, CTCs, CSCs, EMT, clinical trials Received : February 02, 2015 Accepted : April 20, 2015 Published : May 08, 2015 Abstract Tumor relapse and metastasis are the primary causes of poor survival rates in patients with advanced cancer despite successful resection or chemotherapeutic treatment. A primary cause of relapse and metastasis is the persistence of cancer stem cells (CSCs), which are highly resistant to chemotherapy. Although highly efficacious drugs suppressing several subpopulations of CSCs in various tissue-specific cancers are available, recurrence is still common in patients. To find more suitable therapy for relapse, the mechanisms underlying metastasis and drug-resistance associated with relapse-initiating CSCs need to be identified. Recent studies in circulating tumor cells (CTCs) of some cancer patients manifest phenotypes of both CSCs and epithelial-mesenchymal transition (EMT). These patients are unresponsive to standard chemotherapies and have low progression free survival, suggesting that EMT-positive CTCs are related to co-occur with or transform into relapse-initiating CSCs. Furthermore, EMT programming in cancer cells enables in the remodeling of extracellular matrix to break the dormancy of relapse-initiating CSCs. In this review, we extensively discuss the association of the EMT program with CTCs and CSCs to characterize a subpopulation of patients prone to relapses. Identifying the mechanisms by which EMT-transformed CTCs and CSCs initiate relapse could facilitate the development of new or enhanced personalized therapeutic regimens.

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Metadata

Authors
Mitra, A., Mishra, L., & Li, S.
Venue
Oncotarget
Publisher
Impact Journals, LLC
Published
2015-05-08
Volume
6
Issue
13
Pages
10697-10711
ISSN
1949-2553 (ISSN-L)
DOI
10.18632/oncotarget.4037
OpenAlex
W1842991947
Cited by
465
References
131
FWCI
30.55
Type
journal article
Language
en
Open access
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