Low protein-induced increases in FGF21 drive UCP1-dependent metabolic but not thermoregulatory endpoints

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The breadth of FGF21's metabolic actions are governed by FGFR1 in adipose tissue

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Protein Appetite at the Interface between Nutrient Sensing and Physiological Homeostasis

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Dietary protein restriction elevates FGF21 levels and energy requirements to maintain body weight in lean men

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Interorgan communication through peripherally derived peptide hormones inDrosophila

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Regulation of metabolic health by dietary histidine in mice

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FGF21 controls hepatic lipid metabolism via sex-dependent interorgan crosstalk

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Chronic β3‐ AR stimulation activates distinct thermogenic mechanisms in brown and white adipose tissue and improves systemic metabolism in aged mice

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Short‐term protein restriction at advanced age stimulates FGF21 signalling, energy expenditure and browning of white adipose tissue

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Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism

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Adapting to the cold: A role for endogenous fibroblast growth factor 21 in thermoregulation?

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FGF21 acts in the brain to drive macronutrient-specific changes in behavioral motivation and brain reward signaling

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Fibroblast Growth Factor 21 Facilitates the Homeostatic Control of Feeding Behavior

Wu, C.-T., CHAFFIN, A. T. B., & Ryan, K. K. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11030580 · Cited by 22 · see citing works

Preservation of mitochondrial membrane potential is necessary for lifespan extension from dietary restriction

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Protein status modulates the rewarding value of foods and meals to maintain an adequate protein intake

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Revisiting adipose thermogenesis for delaying aging and age-related diseases: Opportunities and challenges

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Short-Term Ketogenic Diet Induces a Molecular Response That Is Distinct From Dietary Protein Restriction

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FGF21 prevents low-protein diet-induced renal inflammation in aged mice

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Methionine Abrogates the Reno-Protective Effect of a Low-Protein Diet Against Diabetic Kidney Disease in Obese Rats with Type 2 Diabetes

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Validation of a Feed Protocol in a Mouse Model That Mimics Marasmic Malnutrition

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Dietary carbohydrates impair the protective effect of protein restriction against diabetes in NZO mice used as a model of type 2 diabetes

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Protein Status Modulates an Appetite for Protein To Maintain a Balanced Nutritional State—A Perspective View

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Severe protein deficiency induces hepatic expression and systemic level of FGF21 but inhibits its hypothalamic expression in growing rats

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Protein-Restricted Diets and Their Impact on Metabolic Health and Aging

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Role of peptide hormones in the adaptation to altered dietary protein intake

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Exploring endocrine FGFs - structures, functions and biomedical applications

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Geroprotective interventions in the 3xTg mouse model of Alzheimer’s disease

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Periodized low protein-high carbohydrate diet confers potent, but transient, metabolic improvements

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What does self‐selection of dietary proteins in rats tell us about protein requirements and body weight control?

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Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice

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Coordinated transcriptional upregulation of oxidative metabolism proteins in long-lived endocrine mutant mice

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Protein Restriction in Metabolic Health: Lessons from Rodent Models

Na, K., & Park, Y. J. (2024) · Nutrients · doi:10.3390/nu16020229 · Cited by 12 · see citing works

Interaction between the amount of dietary protein and the environmental temperature on the expression of browning markers in adipose tissue of rats

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Timing of acute cold exposure determines UCP1 and FGF21 expression - Possible interactions between the thermal environment, thermoregulatory responses, and peripheral clocks

Chau, P. K., Ryan, E., Dalen, K. T., & Haugen, F. (2024) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2024.103938 · Cited by 11 · see citing works

Short-term hypercaloric carbohydrate loading increases surgical stress resilience by inducing FGF21

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Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice

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Biology of Stress Responses in Aging

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Tissue‐Specific Effects of Dietary Protein on Cellular Senescence Are Mediated by Branched‐Chain Amino Acids

Calubag, M. F., Ademi, I., Grunow, I., Breuer, L., Babygirija, R., Lialios, P., Le, S. M., Minton, D. M., Sonsalla, M. M., Illiano, J. A., et al. (2025) · Aging Cell · doi:10.1111/acel.70176 · Cited by 8 · see citing works

Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice

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Rats Self-Select a Constant Protein-to-Carbohydrate Ratio Rather Than a Constant Protein-to-Energy Ratio and Have Low Plasma FGF21 Concentrations

Gehring, J., Azzout‐Marniche, D., Chaumontet, C., Piedcoq, J., Gaudichon, C., & Even, P. C. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab056 · Cited by 7 · see citing works

GCN2 is required to maintain core body temperature in mice during acute cold

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Paracrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male mice

Luk, C., Bridge, K., Warmke, N., Simmons, K. J., Drozd, M., Moran, A., MacCannell, A. D. V., Cheng, C. W., Straw, S., Scragg, J. L., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-54669-1 · Cited by 6 · see citing works

Protein-carbohydrate interaction effects on energy balance, FGF21, IGF-1, and hypothalamic gene expression in rats

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Association of NAFLD with FGF21 Polygenic Hazard Score, and Its Interaction with Protein Intake Level in Korean Adults

Lee, H. J., Shon, J., & Park, Y. J. (2023) · Nutrients · doi:10.3390/nu15102385 · Cited by 5 · see citing works

Body Temperature Regulation Determines Immune Reactions and Species Longevity

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Brain amino acid sensing for organismal amino acid homeostasis

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Dietary Protein Restriction Ameliorates Cardiac Inflammaging via AMPK ‐ ULK1 ‐Mediated Mitochondrial Quality Control

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The hallmarks of protein and amino acid restriction in aging and longevity

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Higher circulating FGF21, lower protein intake, and lower muscle mass: Associations with a higher risk of mortality

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Activation of brown adipose tissue by a low-protein diet ameliorates hyperglycemia in a diabetic lipodystrophy mouse model

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Low protein-induced-FGF-21 signaling remodels adipose tissue on reduced markers of senescence during aging

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Methionine restriction provides sex-specific protection against high-fat diet-induced adiposity, peripheral insulin resistance, and neuroinflammation in FGF21-dependent and independent manners in mice

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Persistent Behavioral and Physiological Effects of Dietary Protein RestrictionPreprint

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Deoxycholic acid derived from the gut microbiota involved in the regulation of adaptive thermogenesis in response to dietary protein restriction in plateau pika

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The metabolic benefits of thermogenic stimulation are preserved in agingPreprint

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Restriction of essential amino acids dictates the systemic response to dietary protein dilutionPreprint

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Paracrine role for endothelial IGF-1 receptor in white adipocyte beigingPreprint

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Effect of PASLoc Meals on the Zootechnical and Nutritional Parameters of Young Wistar Rats Suffering from Induced Moderate Acute Malnutrition

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Adaptive thermogenesis reprograms the behavioural and metabolic responses to protein restriction for successful amino acid homeostasisPreprint

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A nutrient-hormone axis pivots an energy trade-off between resting thermogenesis and movement expenditure

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Développement d'un modèle murin de dénutrition avec entéropathie et évaluation de molécules d'intérêt permettant de contribuer au rétablissement de la fonction de barrière intestinale

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Impact de la déficience en acides aminés indispensables sur le métabolisme protéique et énergétique, et identification de signatures métaboliques

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A pyrexic effect of FGF21 independent of energy expenditure and UCP1

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Prolonged FGF21 treatment increases energy expenditure and induces weight loss in obese mice independently of UCP1 and adrenergic signaling

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FGF21 is an endocrine signal of protein restriction

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Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1

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Relationship between FGF21 and UCP1 levels under time-restricted feeding and high-fat diet

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